This study analyses the impact of climate change on the inflows, sediment loads, and nutrient inputs to the Sabalan dam reservoir, a warm monomictic lake located northwest of Iran. For this purpose, the Soil and Water Assessment Tool (SWAT) was calibrated (2005–2018) and validated (2001–2004). Future climate-based data under the AR5 emission scenarios were obtained from the HadGEM2–ES general circulation model and then downscaled using the LARSWG 6.0. The tuned SWAT model was used to investigate the climate change impact on the hydrological processes and pollution loads to the Sabalan dam reservoir. Our findings based on the Nash–Sutcliffe efficiency coefficient and the coefficient of determination indicated an acceptable performance of the SWAT model in the simulation of inflows, sediment loads, and nutrient inputs to the reservoir. Inflow and sediment load to the reservoir will increase during the period of 2030–2070 compared to the base period (1998–2018). The annual total nitrogen (phosphorus) load to the reservoir will increase by 8.5% (9.4%), 7.3% (8.2%), and 5% (3.4%) under the emission scenarios of RCP2.6, RCP4.5, and RCP8.5, respectively. An increase in sediment loads and nutrient inputs to the Sabalan dam reservoir will significantly exacerbate the reservoir eutrophic condition, leading to water quality deterioration with acute consequences for the positive functions of the dam.