Characterization of the interaction of staphylococcal enterotoxin B with CD1d expressed in human renal proximal tubule epithelial cells

Hammamieh, Rasha; Chakraborty, Nabarun; Lin, Yixin; Shupp, Jeffrey W.; Miller, Stacy‐Ann; Morris, Sam; Jett, Marti

doi:10.1186/s12866-015-0344-5

Cited by 2 publications

(3 citation statements)

References 56 publications

(72 reference statements)

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“…Lactic acid bacteria, especially Lactobacillus spp ., are important in maintaining intestinal homeostasis as they are capable of reducing pH by lactic acid production, compete with potential pathogens, and produce bacteriocins [ 37 , 38 ]. However, the number of Lactobacillus has been observed to decrease with the age and specially after the weaning transition period [ 39 – 42 ]. The process of weaning the piglet from the sow and thereby the switch from milk to solid feed significantly increased in the number of haemolytic bacteria in faeces between 28 and 34 days of age.…”

Section: Discussionmentioning

confidence: 99%

“…The process of weaning the piglet from the sow and thereby the switch from milk to solid feed significantly increased in the number of haemolytic bacteria in faeces between 28 and 34 days of age. Indeed, the gastrointestinal microbiota is strongly influenced by diet, both by the change in milk composition during suckling period [ 39 – 42 ], by the switch from the dam’s milk to the solid feed, and generally an increase in microbial richness and complexity occurs between birth and the post-weaning period [ 40 , 41 ]. The observed effect of age of piglets on the metabolomics profile and bacterial population will not be discussed in depth here, as it was not the primary focus of the present study.…”

Section: Discussionmentioning

confidence: 99%

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Effects of alpha-(1,2)-fucosyltransferase genotype variants on plasma metabolome, immune responses and gastrointestinal bacterial enumeration of pigs pre- and post-weaning

et al. 2018

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In pigs, the alpha-(1,2) fucosyltransferase (FUT1) gene has been highlighted for its properties in controlling the intestinal expression of enterotoxigenic E. coli (ETEC) F18 receptors; a pathogen causing edema disease and post-weaning diarrhoea. In this study, we hypothesized that pigs with different genotypes (ETEC F18 resistant (FUT1AA) versus susceptible (FUT1AG)) differed in following systemic and enteric responses: growth performance, plasma metabolic profiles, expression of candidate genes for intestinal mucosal homeostasis and immunity, number of selected bacteria and the concentration of short-chain fatty acids (SCFA) in faeces and digesta in piglets pre and post-weaning, and on the ETEC F18 adherence ex vivo. Genotype had the strongest impact on plasma metabolomic profile on day 7 and 28 of age. FUT1AG piglets had higher level of N-methyl-2-pyrrolidinone, hippuric acid, oxindole, and 3-oxo-5-beta-chol-7-en-24-oic acid on day 7, and a higher level of guanosine on day 28 than that in the FUT1AA piglets. FUT1AA piglets had a higher level of betaine on day 7 and 3-methylguanine on day 28. On day 34 of age, the FUT1AA pigs had higher levels of S-2-hydroxyglutarate, L-phenylalanine, tauroursodeoxycholic acid and an undetermined PC/LysoPC, while Ile Glu Phe Gly peptide and genistein 5-O-glucuronide, and PC (18:0/0:0) were at higher levels in the FUT1AG piglets. FUT1 genotype did not affect the growth performance and expression of candidate genes. FUT1AG piglets had a higher number of haemolytic bacteria in faeces and in digesta than that in FUT1AA at 34 days of age. The colonic acetic acid concentration was highest in FUT1AG piglets. FUT1 genotype may influence not only the expression of E. coli F18 receptors but could potentially impact the gut homeostasis and metabotype of piglets pre and post-weaning. Further investigations on the relation between FUT1 genotype and these aspects including the intestinal commensal microbiota will expand the knowledge on factors affecting the intestinal ecosystem.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of alpha-(1,2)-fucosyltransferase genotype variants on plasma metabolome, immune responses and gastrointestinal bacterial enumeration of pigs pre- and post-weaning

et al. 2018

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“…56,99 In this context, it is notable that iNKT cells can also be activated by bacterially derived superantigens. 100,101 Moreover, anything that changes the composition of the commensal microbiota could also potentially impact iNKT cells. Host-derived variables, like gender and genetics, are known to impact the microbiota.…”

Section: Discussionmentioning

confidence: 99%

The interaction between invariant Natural Killer T cells and the mucosal microbiota

Hapil¹,

Wingender

2018

Immunology

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SummaryThe surface of mammalian bodies is colonized by a multitude of microbial organisms, which under normal conditions support the host and are considered beneficial commensals. This requires, however, that the composition of the commensal microbiota is tightly controlled and regulated. The host immune system plays an important role in the maintenance of this microbiota composition. Here we focus on the contribution of one particular immune cell type, invariant Natural Killer T (iNKT) cells, in this process. The iNKT cells are a unique subset of T cells characterized by two main features. First, they express an invariant T-cell receptor that recognizes glycolipid antigens presented by CD1d, a non-polymorphic major histocompatibility complex class I-like molecule. Second, iNKT cells develop as effector/memory cells and swiftly exert effector functions, like cytokine production and cytotoxicity, after activation. We outline the influence that the mucosal microbiota can have on iNKT cells, and how iNKT cells contribute to the maintenance of the microbiota composition.

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Characterization of the interaction of staphylococcal enterotoxin B with CD1d expressed in human renal proximal tubule epithelial cells

Cited by 2 publications

References 56 publications

Effects of alpha-(1,2)-fucosyltransferase genotype variants on plasma metabolome, immune responses and gastrointestinal bacterial enumeration of pigs pre- and post-weaning

Effects of alpha-(1,2)-fucosyltransferase genotype variants on plasma metabolome, immune responses and gastrointestinal bacterial enumeration of pigs pre- and post-weaning

The interaction between invariant Natural Killer T cells and the mucosal microbiota

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