2019
DOI: 10.1590/s0102-865020190110000007
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Characterization of the intestinal graft in a swine hypotensive after brain death model

Abstract: To establish a hypotensive brain death pig model and observe the effects of hypotension on small bowel donors. Methods: The hypotensive brain death model was produced using the modified intracranial water sac inflation method in ten domestic crossbred pigs. Effects of hypotensive brain death on small bowel tissue morphology were evaluated through changes in intestinal tissue pathology, tight junction protein of the intestinal mucosa and plasma intestinal fatty acid-binding protein (i-FABP) levels. The pathophy… Show more

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Cited by 2 publications
(1 citation statement)
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“…Brain death results in the loss of control of the enteric nervous system, which may cause intestinal dysmotility and mucosa damage (11). The body-wide inflammation caused by brain death also results in intestinal damage (12), which is reciprocally associated with homeostasis in the colonization of the gut by resident bacteria.…”
Section: Introductionmentioning
confidence: 99%
“…Brain death results in the loss of control of the enteric nervous system, which may cause intestinal dysmotility and mucosa damage (11). The body-wide inflammation caused by brain death also results in intestinal damage (12), which is reciprocally associated with homeostasis in the colonization of the gut by resident bacteria.…”
Section: Introductionmentioning
confidence: 99%