Characterization of the mechanical properties of skin by inverse analysis combined with the indentation test

Delalleau, Alexandre; Josse, Gwendal; Lagarde, Jean‐Michel; Zahouani, H.; Bergheau, Jean‐Michel

doi:10.1016/j.jbiomech.2005.05.001

Cited by 193 publications

(119 citation statements)

References 12 publications

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“…In a finite element modelling context, it implies that using a single set of mechanical properties for the stratum corneum would limit the domain of validity of the simulation results to specific conditions. A wide array of experimental and clinical measurement techniques are used to characterise particular aspects of skin biology and biophysics (Alexiades-Armenakas, 2007;Batisse et al, 2002;Bellemere et al, 2009;Delalleau et al, 2006;Diridollou et al, 2000;Gunner et al, 1979;Hendriks et al, 2006;Jor et al, 2013;Limbert and Simms, 2013;Tonge et al, 2013a;Tonge et al, 2013b;Wan Abas, 1994). Nevertheless, complementary approaches based on mathematical and computational modelling techniques offer promising avenues to further our understanding of the skin (Areias et al, 2003;Bischoff et al, 2000;Boissieux et al, 2000;Buganza Tepole and Kuhl, 2014;Cavicchi et al, 2009;Duan et al, 2000;Evans, 2009;Flynn and McCormack, 2008a, b;Flynn andMcCormack, 2009, 2010;Hendriks et al, 2006;Hendriks et al, 2003;Kuwazuru et al, 2008;Larrabee and Galt, 1986a, b;Larrabee and Sutton, 1986;Lévêque and Audoly, 2013;Tepole et al, 2014a;Tepole et al, 2014b;Tepole et al, 2011;Zöllner et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

Leyva-Mendivil

Page

Bressloff

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

109

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A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.www.elsevier.com/locate/jmbbm 1 A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin. AbstractThe study of skin biophysics has largely been driven by consumer goods, biomedical and cosmetic industries which aim to design products that efficiently interact with the skin and/or modify its biophysical properties for health or cosmetic benefits. The skin is a hierarchical biological structure featuring several layers with their own distinct geometry and mechanical properties. Up to now, no computational models of the skin have simultaneously accounted for these geometrical and material characteristics to study their complex biomechanical interactions under particular macroscopic deformation modes.The goal of this study was, therefore, to develop a robust methodology combining histological sections of human skin, image-processing and finite element techniques to address fundamental questions about skin mechanics and, more particularly, about how macroscopic strains are transmitted and modulated through the epidermis and dermis. The work hypothesis was that, as skin deforms under macroscopic loads, the stratum corneum does not experience significant strains but rather folds/unfolds during skin extension/compression.A sample of fresh human mid-back skin was processed for wax histology. Sections were stained and photographed by optical microscopy. The multiple images were stitched together to produce a larger region of interest and segmented to extract the geometry of the stratum corneum, viable epidermis and dermis. From the segmented structures a 2D finite element mesh of the skin composite model was created and geometrically non-linear plane-strain finite element analyses were conducted to study the sensitivity of the model to variations in mechanical properties.The hybrid experimental-computational methodology has offered valuable insights into the simulated mechanics of the skin, and that of the stratum corneum in particular, by providing qualitative and quantitative information on strain magnitude and distribution. Through a complex non-linear interplay, the geometry and mechanical characteristics of the skin layers (and their relative balance), play a critical role in conditioning the skin mechanical response to macroscopic in-plane compression and extension. Topographical features of the skin surface such as furrows were shown to act as an efficient means to deflec...

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Section: Introductionmentioning

confidence: 99%

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

Leyva-Mendivil

Page

Bressloff

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

109

View full text Add to dashboard Cite

show abstract

“…1,2 It is also known to tolerate almost large deformation loads when removed from a subject's body. 3,4 The mechanical behavior of many biological tissues, such as skin, has a close relationship with their microstructure. 5 The elastin, as one of the main microstructural components, has been shown to have a key asset in strain recovery of the skin and its contribution to the elasticity modulus is small.…”

Section: Introductionmentioning

confidence: 99%

“…5 The elastin, as one of the main microstructural components, has been shown to have a key asset in strain recovery of the skin and its contribution to the elasticity modulus is small. 3 However, the type I collagen fiber has a vital role not only in large deformation but in the anisotropy and tensile strength of the skin. 4,6 Collagen is a primary element of soft tissues, especially the skin tissue.…”

Section: Introductionmentioning

confidence: 99%

Mechanical characterization of the rat and mice skin tissues using histostructural and uniaxial data

2015

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The skin tissue has been shown to behave like a nonlinear anisotropic material. This study was aimed to employ a constitutive fiber family equation to characterize the nonlinear anisotropic mechanical behavior of the rat and mice skin tissues in different anatomical locations, including the abdomen and back, using histostructural and uniaxial data. The rat and mice skin tissues were excised from the animals' body and then the histological analyses were performed on each skin type to determine the mean fiber orientation angle. Afterward, the preconditioned skin tissues were subjected to a series of quasi-static axial and circumferential loads until the incidence of failure. The crucial role of fiber orientation was explicitly added into a proposed strain energy density function. The material coefficients were determined using the constrained nonlinear optimization method based on the axial and circumferential extension data of the rat and mice samples at different anatomical locations. The material coefficients of the skins were given with R 2 0.998. The results revealed a significant load-bearing capacity and stiffness of the rat abdomen compared to the rat back tissues. In addition, the mice abdomen showed a higher stiffness in the axial direction in comparison with circumferential one, while the mice back displayed its highest stiffness in the circumferential direction. The material coefficients of the rat and mice skin tissues were determined and well compared to the experimental data. The optimized fiber angles were also compared to the experimental histological data, and in all cases less than 11.85% differences were observed in both the skin tissues.

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“…Among di erent numerical approaches, Inverse Finite Element Method (IFEM) has been found to be an e ective technique to obtain material properties using experimental data [25][26][27][28]. IFEM could be used to solve complex problems, physically or geometrically, with more details and accuracy.…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, they used trial and error approach to nd hyperelastic parameters, which needed more calculations to give the optimized parameters; moreover, the study did not consider other hyperelastic materials such as Ogden, Arruda-Boyce, etc. Delalleau and his co-workers used inverse analysis combined with extended Kalman lter to determine the mechanical properties of human skin [26]. However, in Kalman lter method, the divergence of the covariance matrix was a big problem.…”

Section: Introductionmentioning

confidence: 99%

Application of Hyperelastic Models in Mechanical Properties prediction of Mouse Oocyte and Embryo Cells at Large Deformations

et al. 2017

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Abstract. Biological cell studies have many applications in biology, cell manipulation, and diagnosis of diseases such as cancer and malaria. In this study, Inverse Finite Element Method (IFEM) combined with Levenberg-Marquardt optimization algorithm has been used to extract and characterize material properties of mouse oocyte and embryo cells at large deformations. Then, the simulation results have been validated using data from experimental works. In this study, it is assumed that cell material is hyperelastic, isotropic, homogenous, and axisymmetric. For inverse analysis, FEM model of cell injection experiment implemented in Abaqus software has been coupled with Levenberg-Marquardt optimization algorithm written in Matlab; through this coupling, the optimum hyperelastic coe cients, which give the best match between experimental and simulated forces, are extracted. Results show that among di erent hyperelastic material models, Ogden material is suitable for characterization of mouse oocyte cell and Mooney-Rivlin or polynomial is suitable for characterization of mouse embryo cell. Moreover, the evaluated Poisson ratio of the cell is obtained to be equal to 0.5, which indicates that the structural materials of mouse oocyte and embryo are compressible.

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Characterization of the mechanical properties of skin by inverse analysis combined with the indentation test

Cited by 193 publications

References 12 publications

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

Mechanical characterization of the rat and mice skin tissues using histostructural and uniaxial data

Application of Hyperelastic Models in Mechanical Properties prediction of Mouse Oocyte and Embryo Cells at Large Deformations

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