Characterization of the metabolites of <i>trans</i>-resveratrol-3-<i>O</i>-glucoside in monkeys and dogs

Mei-ying, SU; Dong, Chen; Wan, Jiyun; Qu, Wendong; Mao-jin, Zhou

doi:10.1080/10286020.2021.1878157

Cited by 3 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Then the loss of the C 2 H 2 O fragment was observed, and the ion at m/z 185.0594 (C 12 H 10 O 3 ) was produced. Combined with mass spectrometry data and references, it was identified as trans‐polydatin [31, 32]. In Figure S5B, in negative mode, Peak 4 with a [M‐H] − formula of C 21 H 20 O 10 at m/z 431.0986.…”

Section: Resultsmentioning

confidence: 99%

Discovery of the potential neuraminidase inhibitors from Polygonum cuspidatum by ultrafiltration combined with mass spectrometry guided by molecular docking

Wang

Chen

Sun

et al. 2023

J of Separation Science

View full text Add to dashboard Cite

Neuraminidase is an important target in the treatment of the influenza A virus.Screening natural neuraminidase inhibitors from medicinal plants is crucial for drug research. This study proposed a rapid strategy for identifying neuraminidase inhibitors from different crude extracts (Polygonum cuspidatum, Cortex Fraxini, and Herba Siegesbeckiae) using ultrafiltration combined with mass spectrometry guided by molecular docking. Firstly, the main component library of the three herbs was established, followed by molecular docking between the components and neuraminidase. Only the crude extracts with numbers of potential neuraminidase inhibitors identified by molecular docking were selected for ultrafiltration. This guided approach reduced experimental blindness and improved efficiency. The results of molecular docking indicated that the compounds in Polygonum cuspidatum demonstrated good binding affinity with neuraminidase. Subsequently, ultrafiltration-mass spectrometry was employed to screen for neuraminidase inhibitors in Polygonum cuspidatum. A total of five compounds were fished out, and they were identified as trans-polydatin, cispolydatin, emodin-1-O-β-D-glucoside, emodin-8-O-β-D-glucoside, and emodin.The enzyme inhibitory assay showed that they all had neuraminidase inhibitory effects. In addition, the key residues of the interaction between neuraminidase and fished compounds were predicted. In all, this study could provide a strategy for the rapid screening of the potential enzyme inhibitors from medicinal herbs.

show abstract

Section: Resultsmentioning

confidence: 99%

Discovery of the potential neuraminidase inhibitors from Polygonum cuspidatum by ultrafiltration combined with mass spectrometry guided by molecular docking

Wang

Chen

Sun

et al. 2023

J of Separation Science

View full text Add to dashboard Cite

show abstract

“…Polydatin, like other polyphenolic compounds, has low absolute bioavailability (2•9% (89) ) and fast metabolism. The rapid clearance of polydatin and its metabolites could lead to low accumulation of effective compounds in targeted tissues (20) . Take the example of resveratrol.…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

“…Polydatin undergoes extensive first-pass deglycosylation and glucuronidation (18) . Upon intake, it is primarily distributed in the gastrointestinal tract and liver, and the intestine is the main organ where polydatin is hydrolysed into resveratrol, its aglycones (15,19,20) . The resulting resveratrol then undergoes further glucuronidation in the intestine and liver to form glucuronide and sulphate conjugates, which are excreted in urine and bile afterward (15,20) .…”

Section: Pharmacokinetics Of Polydatinmentioning

confidence: 99%

Protective effects of polydatin against bone and joint disorders: thein vitroandin vivoevidence so far

et al. 2023

View full text Add to dashboard Cite

Polydatin is an active polyphenol displaying multifaceted benefits. Recently, growing studies have noticed its potential therapeutic effects on bone and joint disorders (BJDs). Therefore, this article reviews recent in vivo and in vitro progress on the protective role of polydatin against BJDs. An insight into the underlying mechanisms is also presented. It was found that polydatin could promote osteogenesis in vitro, and symptom improvements have been disclosed with animal models of osteoporosis, osteosarcoma, osteoarthritis, and rheumatic arthritis. These beneficial effects obtained in laboratory could be mainly attributed to the bone metabolism-regulating, anti-inflammatory, antioxidative, apoptosis-regulating, and autophagy-regulating functions of polydatin. However, studies on human subjects with BJDs that can lead to early identification of the clinical efficacy and adverse effects of polydatin have not been reported yet. Accordingly, this review would serve as a starting point for pursuing clinical trials. Additionally, future emphasis should also be devoted to the low bioavailability and prompt metabolism nature of polydatin. In summary, well-designed clinical trials of polydatin in BJD patients are in demand, and its pharmacokinetic nature must be taken into account.

show abstract

Pleiotropic Effects of Resveratrol on Aging-Related Cardiovascular Diseases—What Can We Learn from Research in Dogs?

Grzeczka,

Graczyk,

Kordowitzki

2024

Cells

View full text Add to dashboard Cite

Resveratrol (RES) is a polyphenol with natural anti-inflammatory and antioxidant properties. It is found in abundance in plants, i.e., grapes and mulberry fruit. In addition, synthetic forms of RES exist. Since the discovery of its specific biological properties, RES has emerged as a candidate substance not only with modeling effects on the immune response but also as an important factor in preventing the onset and progression of cardiovascular disease (CVD). Previous research provided strong evidence of the effects of RES on platelets, mitochondria, cardiomyocytes, and vascular endothelial function. In addition, RES positively affects the coagulation system and vasodilatory function and improves blood flow. Not only in humans but also in veterinary medicine, cardiovascular diseases have one of the highest incidence rates. Canine and human species co-evolved and share recent evolutionary selection processes, and interestingly, numerous pathologies of companion dogs have a human counterpart. Knowledge of the impact of RES on the cardiovascular system of dogs is becoming clearer in the literature. Dogs have long been recognized as valuable animal models for the study of various human diseases as they share many physiological and genetic similarities with humans. In this review, we aim to shed light on the pleiotropic effects of resveratrol on cardiovascular health in dogs as a translational model for human cardiovascular diseases.

show abstract

Characterization of the metabolites of trans-resveratrol-3-O-glucoside in monkeys and dogs

Cited by 3 publications

References 13 publications

Discovery of the potential neuraminidase inhibitors from Polygonum cuspidatum by ultrafiltration combined with mass spectrometry guided by molecular docking

Discovery of the potential neuraminidase inhibitors from Polygonum cuspidatum by ultrafiltration combined with mass spectrometry guided by molecular docking

Protective effects of polydatin against bone and joint disorders: thein vitroandin vivoevidence so far

Pleiotropic Effects of Resveratrol on Aging-Related Cardiovascular Diseases—What Can We Learn from Research in Dogs?

Contact Info

Product

Resources

About