2000
DOI: 10.1128/aac.44.5.1229-1235.2000
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Characterization of the Metallo-β-Lactamase Determinant of Acinetobacter baumannii AC-54/97 Reveals the Existence of bla IMP Allelic Variants Carried by Gene Cassettes of Different Phylogeny

Abstract: The metallo-␤-lactamase determinant of Acinetobacter baumannii AC-54/97, a clinical isolate from Italy that was previously shown to produce an enzyme related to IMP-1, was isolated by means of a PCR methodology which targets amplification of gene cassette arrays inserted into class 1 integrons. Sequencing revealed that this determinant was an allelic variant (named bla IMP-2 ) of bla IMP found in Japanese isolates and that it was divergent from the latter by 12% of its nucleotide sequence, which evidently had … Show more

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Cited by 242 publications
(244 citation statements)
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“…Likewise, both are often encoded by mobile gene cassettes inserted into integrons that are sometimes located on plasmids (Levasque et al, 1995;Bush, 1998). Several close relatives of IMP-1 have been reported: IMP-2 from an isolate of A. baumannii in Italy (Riccio et al, 2000), IMP-3 from Shigella flexneri in Japan (Iyobe et al, 2000), and IMP-4 from Acinetobacter and Citrobacter spp. from Hong Kong (Chu et al, 2001).…”
Section: β-Lactamase Genotypingmentioning
confidence: 99%
“…Likewise, both are often encoded by mobile gene cassettes inserted into integrons that are sometimes located on plasmids (Levasque et al, 1995;Bush, 1998). Several close relatives of IMP-1 have been reported: IMP-2 from an isolate of A. baumannii in Italy (Riccio et al, 2000), IMP-3 from Shigella flexneri in Japan (Iyobe et al, 2000), and IMP-4 from Acinetobacter and Citrobacter spp. from Hong Kong (Chu et al, 2001).…”
Section: β-Lactamase Genotypingmentioning
confidence: 99%
“…Whereas metallocarbapenemases in A. baumannii are reported mostly from Asia and South America and rarely from southern Europe (10,18,19), the carbapenem-hydrolyzing oxacillinases seem to have a wider distribution (1)(2)(3)(4)(5)(6)(7)14). Further work should analyze the spread of those carbapenem-hydrolyzing oxacillinases, including OXA-58, in carbapenem-resistant A. baumannii isolates from the United States, a country where carbapenem-hydrolyzing oxacillinases have not yet been detected.…”
mentioning
confidence: 99%
“…(15,16), Legionella gormanii (17), S. maltophilia (18), and Caulobacter crescentus (19). The mobile metallo-␤-lactamase genes encoding for IMP-1 and VIM-1 (and variants thereof) have been disseminated by both plasmid-and integron-mediated systems and have been identified in a number of organisms, including Pseudomonas aeruginosa (20,21), Acinetobacter baumannii (22), and Serratia marscescens (23). Crystal structures have been determined for four metallo-␤-lactamases: B. cereus (BcII) (24 -26), B. fragilis (CcrA) (27,28), P. aeruginosa (IMP-1) (29), and S. maltophilia (L1) (30).…”
mentioning
confidence: 99%