Characterization of the Morphological Nature of Hollow Spray Dried Dispersion Particles Using X-ray Submicron-Computed Tomography

Gamble, John F.; Tobyn, Mike; Zhang, Shawn; Zhu, Aiden; Šalplachta, Jakub; Matula, Jan; Zikmund, Tomáš; Kaiser, Jozef; Oberta, P.

doi:10.1208/s12249-021-02184-7

Cited by 11 publications

(2 citation statements)

References 22 publications

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“…The distinct morphology of the spray-dried particles was in agreement with other studies, in which hollow particles were also produced by spray drying [ 54 , 55 ]. As stated, some of these cavities may be attributed to the shrinkage process, when the integrated bubbles in the drop dilated.…”

Section: Discussionsupporting

confidence: 91%

Antioxidant Potential of Spray- and Freeze-Dried Extract from Oregano Processing Wastes, Using an Optimized Ultrasound-Assisted Method

Vareltzis,

Stergiou,

Kalinderi

et al. 2023

Foods

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Origanum vulgare is recognized worldwide for its numerous applications, in the food industry and beyond. However, the extraction of its essential oils generates a significant amount of waste. The aim of this research was to achieve the valorization of solid waste from oregano hydro-distillation, by (i) optimizing the ultrasound extraction of antioxidants, (ii) evaluating the effect of spray and freeze drying on the extract’s physicochemical properties, and (iii) characterizing the obtained powder by its antioxidant capacity. A central composite design of experiments was used to optimize the sample/solvent ratio, ethanol/water ratio, and extraction time. The extract was analyzed for its antioxidant potential by determining the percentage of DPPH inhibition, FRAP, and total phenolic content (TPC). The GAB model best fit the data for the moisture sorption isotherm of the resulting powder. The antioxidant activity of the powders was tested in a ground-beef food system. The TPC was maximized at times longer than 58 min, a sample/solvent ratio between 0.058 and 0.078, and a ratio of ethanol/water around 1. Neither drying method significantly affected the antioxidant properties of the extract, even though the resulting powders from each showed a different morphology (determined using SEM). Encapsulation with maltodextrin protected the spray-dried extract during a 6-month storage period. Powders from both drying methods equally retarded lipid oxidation, and were comparable to the synthetic antioxidant BHT. It is concluded that oregano processing waste is a potent source of antioxidants, and that its dried extract, via an ultrasound-assisted process, can potentially be used as a natural alternative to synthetic antioxidants.

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Section: Discussionsupporting

confidence: 91%

Antioxidant Potential of Spray- and Freeze-Dried Extract from Oregano Processing Wastes, Using an Optimized Ultrasound-Assisted Method

Vareltzis,

Stergiou,

Kalinderi

et al. 2023

Foods

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show abstract

“…These characteristics yield information about the nature of the respective sample and do not necessarily describe individual particles. Although this is part of recent investigations in spray dried, spherical particles and metal particles [ 10 , 11 , 12 , 13 ], non-spherical particles are seldom covered. Samples containing spherical individual particles allow for efficient application of artificial intelligence (AI) methods and post-processing algorithms.…”

Section: Introductionmentioning

confidence: 99%

Determination of Particle Size Distributions of Bulk Samples Using Micro-Computed Tomography and Artificial Intelligence

et al. 2023

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The knowledge of product particle size distribution (PSD) in crystallization processes is of high interest for the pharmaceutical and fine chemical industries, as well as in research and development. Not only can the efficiency of crystallization/production processes and product quality be increased but also new equipment can be qualitatively characterized. A large variety of analytical methods for PSDs is available, most of which have underlying assumptions and corresponding errors affecting the measurement of the volume of individual particles. In this work we present a method for the determination of particle volumes in a bulk sample via micro-computed tomography and the application of artificial intelligence. The particle size of bulk samples of sucrose were measured with this method and compared to classical indirect measurement methods. Advantages of the workflow are presented.

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Assessing the Interrelationship of Microstructure, Properties, Drug Release Performance, and Preparation Process for Amorphous Solid Dispersions Via Noninvasive Imaging Analytics and Material Characterization

Jia¹,

Yawman

Pandya³

et al. 2022

Pharm Res

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Characterization of the Morphological Nature of Hollow Spray Dried Dispersion Particles Using X-ray Submicron-Computed Tomography

Cited by 11 publications

References 22 publications

Antioxidant Potential of Spray- and Freeze-Dried Extract from Oregano Processing Wastes, Using an Optimized Ultrasound-Assisted Method

Antioxidant Potential of Spray- and Freeze-Dried Extract from Oregano Processing Wastes, Using an Optimized Ultrasound-Assisted Method

Determination of Particle Size Distributions of Bulk Samples Using Micro-Computed Tomography and Artificial Intelligence

Assessing the Interrelationship of Microstructure, Properties, Drug Release Performance, and Preparation Process for Amorphous Solid Dispersions Via Noninvasive Imaging Analytics and Material Characterization

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