Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation

Wray, Susan; Cope, M; Delpy, David T.; Wyatt, John; Reynolds, E. O. R.

doi:10.1016/0005-2728(88)90069-2

Cited by 831 publications

(505 citation statements)

References 13 publications

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“…Light for the NIRS from six laser diodes (wavelengths 780, 808, 828, 850, 870, and 904 nm) was directed into the head through a fiberoptic bundle. Using an algorithm developed by Wray et al (1988), the variation in NIRS absorption was continuously analyzed by means of a computer incorpo rated into the apparatus. The change in CBV was consid ered to be that of total hemoglobin (�HbT = �Hb02 + �HbR) (Wyatt et al, 1986).…”

Section: Methodsmentioning

confidence: 99%

Human Visual Cortical Function during Photic Stimulation Monitoring by Means of near-Infrared Spectroscopy

Kato¹,

Kamei²,

Takashima³

et al. 1993

J Cereb Blood Flow Metab

411

225

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Summary: Near-infrared spectroscopy (NIRS) was used to monitor human visual cortical function during and after photic stimulation (PS) in five adult volunteers. Cerebral blood volume (CBV) increased on the occipital surface during PS, but NIRS parameters did not change on the frontal surface. The increase in CBV was caused by a rapid increase in oxyhemoglobin with but a small increase in deoxyhemoglobin, suggesting cerebral vascular dilata tion with decreased oxygen consumption. After PS A study of human subjects using positron emis sion tomography (PET) indicated that photic stim ulation (PS) raises blood flow and glucose consump tion in the visual cortex by about 50%, whereas oxygen consumption increases only 5% (Fox et al., 1988). Using proton magnetic resonance spectros copy, Prichard et al. (1991) demonstrated that PS causes an increase in brain lactate in the human visual cortex. However, the mechanism of PS ac tion on human visual cortical function is still not clear. Near-infrared spectroscopy (NIRS) is a non invasive tool for the continuous monitoring of changes in cerebral blood volume (CBV), oxyhemo globin (Hb02), deoxyhemoglobin (HbR) and redox state of cytochrome aa3 (Cyt). Voluntary hypervenReceived February 11, 1992; final revision received October 27, 1992; accepted October 27, 1992.Address correspondence and reprint requests to Dr. Toshinori Kato, Mental Retardation and Birth Defect Research Division, National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi cho, Kodaira, Tokyo, Japan.Abbreviations used: CBV, cerebral blood volume; Cyt, cy tochrome aa3; DPF, differential path length factor; HbR, de oxyhemoglobin; Hb02, oxyhemoglobin; HbT, total hemoglobin (Hb02 + HbR); MRI, magnetic resonance imaging; NIRS, near infrared spectroscopy; PET, positron emission tomography; PC, photon count; PS, photic stimulation. 516stopped, CBV promptly decreased and then slightly in creased again. Cytochrome aa3 did not show any change during and after PS. These phenomena reappeared fol lowing repeated PS in all five subjects. These results may represent the first step in the development of NIRS im aging.

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Section: Methodsmentioning

confidence: 99%

Human Visual Cortical Function during Photic Stimulation Monitoring by Means of near-Infrared Spectroscopy

Kato¹,

Kamei²,

Takashima³

et al. 1993

J Cereb Blood Flow Metab

411

225

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“…73,74 In the near-infrared range (650-1000 nm), oxyhemoglobin (HbO 2 ), deoxyhemoglobin (dHb), and oxidized cytochrome oxidase have characteristic absorption spectra. 75 76 It was subsequently found that adducts form with thiol groups in proteins, peptides and amino acids in such a way that all atoms of the ring and side-chain of the 2-nitroimidazole are retained. 77,78 Hypoxia (pO 2 < 10 mmHg) is required for binding, which suggests that bioreductive markers (2-nitroimidazole derivatives) can be used to detect hypoxic cells.…”

Section: Techniques For the Assessment Of Tumor Oxygenationmentioning

confidence: 99%

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

2004

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This review paper attempts to provide an overview of the principles and techniques that are often termed electron paramagnetic resonance (EPR) oximetry. The paper discusses the potential of such methods and illustrates they have been successfully applied to measure oxygen tension, an essential parameter of the tumor microenvironment. To help the reader understand the motivation for carrying out these measurements, the importance of tumor hypoxia is first discussed: the basic issues of why a tumor is hypoxic, why these hypoxic microenvironments promote processes driving malignant progression and why hypoxia dramatically influences the response of tumors to cytotoxic treatments will be explained. The different methods that have been used to estimate the oxygenation in tumors will be reviewed. To introduce the basics of EPR oximetry, the specificity of in vivo EPR will be discussed by comparing this technique with NMR and MRI. The different types of paramagnetic oxygen sensors will be presented, as well as the methods for recording the information (EPR spectroscopy, EPR imaging, dynamic nuclear polarization). Several applications of EPR for characterizing tumor oxygenation will be illustrated, with a special emphasis on pharmacological interventions that modulate the tumor microenvironment. Finally, the challenges for transposing the method into the clinic will also be discussed.

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“…Absorption occurs at specific wavelengths, determined by the molecular properties of the materials in the light path (Jöbsis, 1977;Wray et al, 1988). The primary light-absorbing compounds in tissue within the near-infrared range are called chromophores (Jöbsis, 1977).…”

Section: Absorption Of Lightmentioning

confidence: 99%

“…Absorption spectra for deoxyhemoglobin (Hb), oxyhemoglobin (HbO 2 ), cytochrome c oxidase (Cyt), and water (H 2 O) in the near-infrared range. The isobestic point near 800 nm is the point where the absorptivity of Hb and HbO 2 are equal (Palmer & Williams, 1974;Wray et al, 1988).…”

Section: Absorption Of Lightmentioning

confidence: 99%

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Near-Infrared Spectroscopy

Bakker¹,

Smith²,

Ainslie³

et al. 2012

Applied Aspects of Ultrasonography in Humans

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Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation

Cited by 831 publications

References 13 publications

Human Visual Cortical Function during Photic Stimulation Monitoring by Means of near-Infrared Spectroscopy

Human Visual Cortical Function during Photic Stimulation Monitoring by Means of near-Infrared Spectroscopy

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

Near-Infrared Spectroscopy

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