Characterization of the raw essential oil eugenol extracted from Syzygium aromaticum L.

Santos, Amilton dos; Chierice, Gilberto Orivaldo; Alexander, Kenneth S.; Riga, Alan T.; Matthews, Ellen

doi:10.1007/s10973-009-0030-7

Cited by 33 publications

(17 citation statements)

References 12 publications

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“…2a, 3a, 4a, 5a, and 6a and was found to be in agreement with the reported thermogram of eugenol (Chaar et al 2004;Monteiro et al 2011;Nuchuchua et al 2009;Santos et al 2009). The DSC curve for the eugenol displayed one endothermic peak, at 258.81°C which attributed to the volatilization of eugenol (Monteiro et al 2011).…”

Section: Differential Scanning Calorimetrysupporting

confidence: 91%

Unveiling the compatibility of eugenol with formulation excipients by systematic drug-excipient compatibility studies

et al. 2015

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Background: The drug-excipient compatibility studies were carried out with the possible excipients viz. Tween 80, Carbopol 940, chitosan, sodium alginate, and polycaprolactone (PCL) for their possible use in the formulation of eugenol loaded nanoemulsion gels and nanoparticles. Methods: The eugenol-excipient compatibility studies were carried out by visual observations, differential scanning calorimetry (DSC), infrared spectroscopy (FTIR), and high-performance thin-layer chromatography (HPTLC). Results: No notable change was observed in the samples on visual observation. From the results of the DSC studies, to a much extent, it was assumed that eugenol was not subjected to any interaction with the selected excipients for the proposed nanoemulsion gel and nanoparticles. But in some cases viz. polycaprolactone and Carbopol, though not to a significant level, slight deviation of the nature and position of the endothermic peaks of eugenol were observed. The results of the IR spectroscopy confirmed the compatibility of eugenol with Tween 80, Carbopol 940, chitosan, sodium alginate, and polycaprolactone. The retention factor of the HPTLC densitogram peaks for all the physical mixtures was well within the retention factor (R f ) value range observed for pure eugenol. Conclusions: The study results confirmed that eugenol is compatible with the selected excipients for the development of nanoemulsion gels and nanoparticles.

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Section: Differential Scanning Calorimetrysupporting

confidence: 91%

Unveiling the compatibility of eugenol with formulation excipients by systematic drug-excipient compatibility studies

et al. 2015

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“…Eugenol has pronounced analgesic properties. In recent years, additional biological properties of this substance have been determined including fungicidal, bactericidal, antioxidant and anti-inflammatory properties 21 . The mechanism of the antimicrobial effect of eugenol has been studied recently.…”

Section: Discussionmentioning

confidence: 99%

In vitro antimicrobial activities of cinnamon bark oil, anethole, carvacrol, eugenol and guaiazulene against Mycoplasma hominis clinical isolates

Sleha¹,

Mosio²,

Vydržalová³

et al. 2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims. The aim of this study was to evaluate the antimicrobial effects of five natural substances against 50 clinical isolates of Mycoplasma hominis. Methods and Results. The in vitro activity of selected natural compounds, cinnamon bark oil, anethole, carvacrol, eugenol and guaiazulene, was investigated against 50 M. hominis isolates cultivated from cervical swabs by the broth dilution method. All showed valuable antimicrobial activity against the tested isolates. Oil from the bark of Cinnamomum zeylanicum (MBC 90 = 500 μg/mL) however was found to be the most effective. Carvacrol (MBC 90 = 600 μg/mL) and eugenol (MBC 90 = 1000 μg/mL) also possessed strong antimycoplasmal activity. Conclusions. The results indicate that cinnamon bark oil, carvacrol and eugenol have strong antimycoplasmal activity and the potential for use as antimicrobial agents in the treatment of mycoplasmal infections.

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“…The onset temperature for the boiling process of clove oil was 156.2°C, and the onset temperature of pure eugenol was 113.5°C. [67] Further, the auto-oxidation process of free eugenol begins at 159°C. [68] Nevertheless, current research demonstrates that eugenol in electrospun nanopolymer is unstable at temperatures of 50°C and greater.…”

Section: Active Compounds Of Clove Oil In the Continuous Phasementioning

confidence: 99%

Emulsion stability of clove oil in chitosan and sodium alginate matrix

Purwanti

Zehn

Pusfitasari

et al. 2018

International Journal of Food Properties

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Clove oil was emulsified in 1% w/w chitosan (CC emulsions) and 2.5% w/w sodium alginate matrix (CA emulsions) containing Tween 80 as the surfactant. Different homogenization speeds (5,000, 10,000, 15,000 and 20,000 rpm) were used to produce the emulsions, and the stability of the emulsions during storage (29 days) was determined. The stability of the emulsions containing clove oil prior to the solidification process was assessed when chitosan and sodium alginate were used as encapsulating materials. Different homogenization speeds resulted in polydisperse emulsions with a size of 2-3 μm and 90% of stability after 29 days of storage. Different homogenization speeds did not significantly affect the concentrations of the active compounds contained in the emulsions. However, these concentrations changed significantly after 29 days of storage when sodium alginate was used to make the emulsions and the homogenization speeds were ≥ 10,000 rpm. High temperature caused by the high viscosity of the solution and high energy dissipation during homogenization suggested that the emulsions composed of sodium alginate were unstable. Chitosan enabled a longer processing time during the clove oil encapsulation process compared to sodium alginate, when emulsification by homogenization was used. The stability of the emulsion of the clove oil-inchitosan matrix prior to the solidification step was superior. ARTICLE HISTORY

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Characterization of the raw essential oil eugenol extracted from Syzygium aromaticum L.

Cited by 33 publications

References 12 publications

Unveiling the compatibility of eugenol with formulation excipients by systematic drug-excipient compatibility studies

Unveiling the compatibility of eugenol with formulation excipients by systematic drug-excipient compatibility studies

In vitro antimicrobial activities of cinnamon bark oil, anethole, carvacrol, eugenol and guaiazulene against Mycoplasma hominis clinical isolates

Emulsion stability of clove oil in chitosan and sodium alginate matrix

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