Characterization of the SCP/TAPS gene family in Drosophila melanogaster

Kovalick, Gae E.; Griffin, Donna L.

doi:10.1016/j.ibmb.2005.03.003

Cited by 28 publications

(33 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The CAP superfamily is characterized by several signature sequences, two of which are defined in the PROS-ITE database (http://www.expasy.ch/prosite/) as: CAP1, [ [LIVMFYWDN]. Two additional motifs are apparent and, while noted previously (1,11,12), have not been adopted as part of the consensus for the superfamily within PROSITE. Herein, we define these two additional conserved sequence motifs as CAP3 (HNxxR) and CAP4 (G[EQ]N[ILV]) (Fig.…”

Section: The Cap Superfamily Conservation and Evolutionary Distrimentioning

confidence: 99%

The CAP Superfamily: Cysteine-Rich Secretory Proteins, Antigen 5, and Pathogenesis-Related 1 Proteins—Roles in Reproduction, Cancer, and Immune Defense

2008

View full text Add to dashboard Cite

The cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) superfamily members are found in a remarkable range of organisms spanning each of the animal kingdoms. Within humans and mice, there are 31 and 33 individual family members, respectively, and although many are poorly characterized, the majority show a notable expression bias to the reproductive tract and immune tissues or are deregulated in cancers. CAP superfamily proteins are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumor suppressor or prooncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. This review describes mammalian CAP superfamily gene expression profiles, phylogenetic relationships, protein structural properties, and biological functions, and it draws into focus their potential role in health and disease. The nine subfamilies of the mammalian CAP superfamily include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. We conclude that overall protein structural conservation within the CAP superfamily results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters target specificity and, therefore, the biological consequences.

show abstract

Section: The Cap Superfamily Conservation and Evolutionary Distrimentioning

confidence: 99%

The CAP Superfamily: Cysteine-Rich Secretory Proteins, Antigen 5, and Pathogenesis-Related 1 Proteins—Roles in Reproduction, Cancer, and Immune Defense

2008

View full text Add to dashboard Cite

show abstract

“…This family includes mammalian sperm-coating glycoprotein; glioma pathogenesis-related protein; a lizard toxin that blocks ryanodine receptors; venom allergens from biting/stinging insects, which are potent allergens; plant pathogenesis proteins of the PR-1 subfamily, which are synthesized during pathogen infection or other stress-related responses; and fungal proteins that are loosely associated with fruiting body hyphal walls. [19][20][21] The functions of most of these proteins are largely unknown, but in hookworms ASPs are very abundant in ES products from L3 parasites undergoing the transition to the parasitic stage, which occurs on activation by host serum. 22,23 In a comprehensive study, Datu et al 24 demonstrated an enormous ''expansion'' of ASPs after serum stimulation of A caninum L3, both in terms of their transcriptional upregulation and numbers of distinct molecules, showing clearly that ASPs are one of the major molecular groups involved in the early phase of the transition to parasitism in A caninum.…”

Section: Natural History Of Hookworm Infection: Molecular Mechanisms mentioning

confidence: 99%

Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines

Pearson¹,

Tribolet²,

Cantacessi³

et al. 2012

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

“…A SMART search identified a putative sperm coating protein (SCP) domain between amino acid residues 31 and 181. Most proteins with this domain are secreted and several are known to be involved in male fertility and fertilisation (Kovalick and Griffin, 1996). Two Acp proteins from D. melanogaster are also predicted to be CRISPs, based on comparative protein modelling (Mueller et al, 2004).…”

Section: Crispmentioning

confidence: 99%