Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines

Abstract

Background Meteorin-like (Metrnl) is an adipokine with insulin sensitizing and anti-inflammatory properties that has been discovered recently. The relation among Metrnl, Inflammatory Bowel Disease (IBD), and obesity has been unexplored yet. Methods The present study was conducted on 54 healthy control, 42 Ulcerative Colitis (UC), and 43 Crohn’s disease (CD) patients who were diagnosed by pathological examination. In all participants, serum levels of adiponectin, Metrnl, interleukin (IL)-6, and Tumor necrosis factor (TNF-α) were measured using ELISA kits. Results Metrnl concentration was considerably lower in both UC (85.25 ± 36.55 pg/mL) and CD (76.93 ± 27.92 pg/mL) patients in comparison to control (107.52 ± 35.33 pg/mL). In addition, it was seen that both patient groups have a decreased level of adiponectin compared to the controls. Besides that, the level of IL-6 and TNF-α were significantly greater in the patient groups. Moreover, the result showed that the level of Metrnl is inversely correlated with body mass index (BMI) in the controls and the patients. Metrnl levels are also inversely associated with IL-6, and TNF-α in both of the patient groups. Conclusions The current study is the first one reporting the decreased levels of Metrnl in serum among patients with IBD, which is inversely related with BMI, TNF-α, and IL-6. These results suggested a possible relation of Metrnl with the pathogenesis of IBD, particularly through inflammatory process, although further studies are warranted to dissect the possible mechanism.

Decreased serum interleukin‐41/Metrnl levels in patients with Graves' disease

“…Several studies demonstrated that serum IL‐41 levels were decreased in T2D patients compared with the healthy controls 21–23 . Moreover, serum IL‐41 concentrations were considerably lower in patients with coronary artery disease 15 and ulcerative colitis and Crohn's disease 24 in comparison with healthy controls. In this study, we also observed a decrease in serum IL‐41 levels in GD patients.…”

Anti-inflammatory Effect of a Novel Pectin Polysaccharide From Rubus chingii Hu on Colitis Mice

“…Experimental results showed nitric oxide synthase iNOS and common inflammatory factors (IL-1β, IL-6, TNF-α) play a key role in inflammation development (29,30). Following LPSstimulated macrophages, the expression of iNOS, IL-1β, IL-6, and TNF-α related genes increased significantly.…”

Role of Adipose Tissue in Inflammatory Bowel Disease

“…There are reports that serum levels of retinol-binding protein 4, another adipokine linked to the metabolic syndrome [ 73 , 119 ], has been reported to be elevated in IBD patients [ 76 ] and inversely correlated with disease activity [ 120 ]. Finally, meteorin-like, a novel adipokine with insulin sensitizing and anti-inflammatory properties, has been recently detected as decreased in patients with IBD [ 121 ]. Meteorin-like levels were inversely related with BMI, TNF-α, and IL-6, which suggested a possible relation with the inflammatory process in IBD.…”