Characterization of the Serum Levels of Meteorin-like in Patients with Inflammatory Bowel Disease and its Association with Inflammatory Cytokines

Abstract

Background : Meteorin-like (Metrnl) is a newly discovered adipokine with insulin sensitizing and anti-inflammatory properties. The relation among Metrnl, Inflammatory Bowel Disease (IBD), and obesity still remained unexplored. Methods : The present study was conducted on 54 healthy control, 42 Ulcerative Colitis (UC), and 43 Crohn's disease (CD) patients who were diagnosed by pathological examination. In all participants, serum levels of adiponectin, Metrnl, interleukin (IL)-6, and Tumor necrosis factor (TNF-α) were measured using ELISA kits.Results: Metrnl concentration was considerably decreased in both UC (85.25±36.55 pg/mL) and CD (76.93±27.92 pg/mL) patients in comparison to control group (107.52±35.33 pg/mL). In addition, the level of adiponectin decreased in these two patient groups compared to the controls. However, IL-6 and TNF-α significantly elevated in the patient groups. Moreover, Metrnl showed an inverse correlation with body mass index (BMI) in the controls and the patients. In addition, there was an inverse correlation among Metrnl, IL-6, and TNF-α in both of the patient groups. Conclusions : The current study is the first one reporting the decreased serum levels of Metrnl in patients with IBD, which is inversely related with BMI, TNF-α, and IL-6. These results suggested a possible relation of Metrnl with the pathogenesis of IBD, particularly through inflammatory process that need further study to dissect the possible mechanism. Keywords : Meteorin-like, Inflammatory Bowel Disease, Ulcerative Colitis, Crohn's disease, Interleukin, Tumor necrosis factor, Adiponectin

Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions

“…This myokine has been shown to contribute to the browning of WAT and, consequently, to greater energy expenditure through the oxidation of glucose and FFA and reduction in fat mass [ 11 ]. METRNL also shows an anti-inflammatory role, especially in reducing adipose inflammation, increasing the expression of M2 macrophages in adipose tissue, and improving insulin resistance typical of obesity [ 62 ]. Figure 2 shows some aspects of myokines and the metabolic effects.…”

Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk

“…IL‐15 contributes to reduce visceral adipose tissue and to enhance insulin action [70]. METRNL has been reported to contribute to energy expenditure through glucose and FFAs oxidation [71]. Thus, elucidation of the roles of myokines, as well as other organokines in the regulation of metabolic homeostasis, holds promise for better understanding of metabolic diseases such as diabetes.…”