Characterization of the Solutol® HS15/water phase diagram and the impact of the Δ9-tetrahydrocannabinol solubilization

Murgia, Sergio; Fadda, Paolo; Colafemmina, Giuseppe; Angelico, Ruggero; Corrado, Luigi; Lazzari, Paolo; Monduzzi, Maura; Palazzo, Gerardo

doi:10.1016/j.jcis.2012.08.068

Cited by 40 publications

(15 citation statements)

References 34 publications

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“…Therefore, a huge number of hard and soft nanocarriers encapsulating drugs or imaging dyes have been designed and applied for various purposes 1 . Hard nanocarriers comprised metallic or polymeric nanoparticles [2][3][4][5][6] , whereas soft nanocarriers include liposomes [7][8][9] , carbon tubes, quantum dots, dendrimers 10,11 , and many more.…”

Section: Introductionmentioning

confidence: 99%

Theranostic combinatorial drug-loaded coated cubosomes for enhanced targeting and efficacy against cancer cells

et al. 2020

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Cubosomes, a product of nanobioengineering, are self-structured lipid nanoparticles that act like drug-loaded theranostic probes. Here, we describe a simple method for the preparation of combinatorial drug-loaded cubosomes with, proof-of-principle, therapeutic effect against cancer cells, along with diagnostic capabilities. Anticancer drugs cisplatin and paclitaxel were loaded in the cubosomes in combination. The cubosomes were coated with a layer of poly-Ɛ-lysine, which helped avoid the initial burst release of drug and allowed for a slow and sustained release for better efficacy. Cubosomes were imaged by transmission electron microscope, and their dispersion analyzed in vitro by differential scanning calorimetric and X-ray diffractogram studies. The microscopic images depicted spherical polyangular structures, which are easily distinguishable. The analyses revealed that the drug is uniformly dispersed all through the cubosomes. Further characterization was carried out by zeta-potential measurement, in vitro release, and entrapment efficiency studies. The in vitro studies established that the coating of cubosomes successfully reduced the burst release of drugs initially and confirmed a slow, sustained release over increased time. Comparative cytotoxicity of coated, uncoated, and blank cubosomes was evaluated, using human hepatoma HepG2 cell line, and the formulations were found to be entirely nontoxic, similar to the blank ones. The therapeutic efficiency of the cubosomes against HeLa cells was confirmed by the impedance measurement and fluorescent imaging. Furthermore, the reduction in impedance in cells treated with coated combinatorial cubosomes proved the impairment of HeLa cells, as confirmed by fluorescence microscopy.

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Section: Introductionmentioning

confidence: 99%

Theranostic combinatorial drug-loaded coated cubosomes for enhanced targeting and efficacy against cancer cells

et al. 2020

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“…An appropriate use of D may be very useful in solving different problems, ranging from clarifying the inner structure of colloidal systems or the mesoscopic order that some molecules possess in solution to the discrimination of molecular aggregate size . In all these cases the concept that underpins the study of the self‐diffusion coefficients is based on the simple observation that the Brownian motions of the molecule under investigation are modified by a specific interaction with another molecule or molecular aggregate, or by a restriction of the molecular displacement due, for example, to the peculiar environment in which the molecular motion occurs .…”

Section: Discussionmentioning

confidence: 99%

A pheromone analogue affects the evaporation rate of (+)‐disparlure in Lymantria dispar

Sollai

Murgia

Secci

et al. 2013

Pest Management Science

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“…In another recent study, Nagi et al employed a Box-Behnken statistical design (BBD) to optimize SIL-loaded nanoemulsions using Capryol 90 as oil phase capable of solubilizing SIL up to 40.00 ± 1.53 mg/mL, in terms of various factors such as processing pressure and number of cycles of HPH technique and amount of surfactant/cosurfactant mixture [46]. The non-ionic hydrophilic surfactant Solutol ® HS 15 was selected due to its high capacity to solubilize hydrophobic drugs and low toxicity (LD50 > 20 mg/kg) [47], and used in combination with Transcutol ® selected as cosurfactant on the basis of the good miscibility with Capryol 90 and Solutol ® HS 15. The optimal nanoemulsion satisfying the criteria of low droplet size and low PDI, necessary for high drug release potential and drug permeation through the GIT membrane, was characterized by nanodroplets of about 50 nm (PDI: 0.45) and zeta potential -31.49 mV.…”

Section: Liquid Emulsions (Les)mentioning

confidence: 99%

Advanced Nanotechnologies for Enhancing the Bioavailability of Silymarin: A State of the Art

Costanzo¹,

Angelico²

2019

Preprint

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Silymarin, a mixture of flavonolignan and flavonoid polyphenolic compounds extractable from the milk thistle seed, Silybum marianum, has anti-oxidant, anti-inflammatory, anti-cancer and anti-viral activities potentially useful in the treatment of several liver disorders, such as chronic liver diseases, cirrhosis and hepatocellular carcinoma. Equally promising are the effects of silymarin in protecting the brain from the inflammatory and oxidative stress effects by which metabolic syndrome contributes to neurodegenerative diseases. However, despite clinical trials have proved that silymarin is safe at high doses (>1500 mg/day) in humans, it suffers limiting factors such as low solubility in water (<50 μg/mL), low bioavailability and poor intestinal absorption. To improve its bioavailability and provide a prolonged silymarin release at the site of absorption, the use of nanotechnological strategies appears to be a promising method to potentiate the therapeutic action and promote sustained release of the active herbal extract. The purpose of this study is to review the different nanostructured systems available in literature as delivery strategies to improve the absorption and bioavailability of silymarin.

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Characterization of the Solutol® HS15/water phase diagram and the impact of the Δ9-tetrahydrocannabinol solubilization

Cited by 40 publications

References 34 publications

Theranostic combinatorial drug-loaded coated cubosomes for enhanced targeting and efficacy against cancer cells

Theranostic combinatorial drug-loaded coated cubosomes for enhanced targeting and efficacy against cancer cells

A pheromone analogue affects the evaporation rate of (+)‐disparlure in Lymantria dispar

Advanced Nanotechnologies for Enhancing the Bioavailability of Silymarin: A State of the Art

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