Characterization of the spontaneous and gripping-induced immobility episodes ontaiep rats

Cortés, Ma. del Carmen; Gavito, Berenice; Ita, Martha L.; Valencia, Jaime; Eguibar, José R.

doi:10.1002/syn.20188

Cited by 17 publications

(8 citation statements)

References 27 publications

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“…Poor sleep quality exacerbates the symptoms associated with multiple sclerosis, and symptoms improve after a nap [211]. In a demyelinating rat model ( taiep rats), REM sleep is abnormal [212], and taiep rats have periods of immobility with sleep-onset REM periods similar to narcolepsy [213]. …”

Section: The Cellular Consequences Of Normal and Prolonged Wakefulmentioning

confidence: 99%

Sleep, Plasticity and the Pathophysiology of Neurodevelopmental Disorders: The Potential Roles of Protein Synthesis and Other Cellular Processes

et al. 2014

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Sleep is important for neural plasticity, and plasticity underlies sleep-dependent memory consolidation. It is widely appreciated that protein synthesis plays an essential role in neural plasticity. Studies of sleep-dependent memory and sleep-dependent plasticity have begun to examine alterations in these functions in populations with neurological and psychiatric disorders. Such an approach acknowledges that disordered sleep may have functional consequences during wakefulness. Although neurodevelopmental disorders are not considered to be sleep disorders per se, recent data has revealed that sleep abnormalities are among the most prevalent and common symptoms and may contribute to the progression of these disorders. The main goal of this review is to highlight the role of disordered sleep in the pathology of neurodevelopmental disorders and to examine some potential mechanisms by which sleep-dependent plasticity may be altered. We will also briefly attempt to extend the same logic to the other end of the developmental spectrum and describe a potential role of disordered sleep in the pathology of neurodegenerative diseases. We conclude by discussing ongoing studies that might provide a more integrative approach to the study of sleep, plasticity, and neurodevelopmental disorders.

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Section: The Cellular Consequences Of Normal and Prolonged Wakefulmentioning

confidence: 99%

Sleep, Plasticity and the Pathophysiology of Neurodevelopmental Disorders: The Potential Roles of Protein Synthesis and Other Cellular Processes

et al. 2014

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“…The name is the acronym of their progressive neurological motor symptoms: tremor, ataxia, immobility episodes, epilepsy, and paralysis (Holmgren et al ). The neurological syndrome is progressive, starting with tremors in the tail and hindlimbs at weaning that decrease in frequency and increase in amplitude with age, followed by ataxia at 2 months of age, with immobility episodes peaking at 8 to 9 months (Cortés, Gavito, Ita, Valencia, & Eguibar, ). Taiep rats also show a progressive increase in absence seizures (Cortés, Silva, & Eguibar, ) and in rats older than 1 year, some degree of hindlimb paralysis is presented (Eguibar, Cortes, Ugarte, & Leon‐Chavez, ).…”

Section: Introductionmentioning

confidence: 99%

Juvenile Taiep rats have shorter dendritic trees in the dorsal field of the hippocampus without spatial learning disabilities

Silva-Gómez

Bravo-Duran

Eguibar

et al. 2018

Synapse

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Myelin mutant taiep rats show a progressive demyelination in the central nervous system due to an abnormal accumulation of microtubules in the cytoplasm and the processes on their oligodendrocytes. Demyelination is associated with electrophysiological alterations and the mutant had a progressive astrocytosis. The illness is associated with change in cytokine levels and in the expression of different nitric oxide synthase and concomitantly lipoperoxidation in several areas of the brain. However, until now there has been no detailed anatomical analysis of neurons in this mutant. The aim of this study was to analyze the dendritic morphology in the hippocampus using Golgi-Cox staining and spatial memory through Morris water maze test in young adult (3 months old) taiep rats and compare them with normal Sprague-Dawley. Our results showed that taiep rats have altered dendritic tree morphology in pyramidal neurons in the CA1 field of the hippocampus, but not in the CA3 region. These morphological changes did not produce a concomitant deficit in spatial memory acquisition or recall at this early stage of the disease. Our results suggest that impairment of dendritic morphology in the CA1 field of the hippocampus is a landmark of the pathology of this progressive multiple sclerosis model.

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“…Thus, authors conclude that sleep evolved to protect animals from parasitic infections [27]. Sleep is also altered in the taiep rats, because they had a disorganized sleep-wake cycle and during immobility episodes a rapid eye movement sleep emerges [9]. So probably sleep alterations it is also involved in the protection seen in this study against parasite load in the taiep rat.…”

Section: Discussionmentioning

confidence: 84%

The lack of myelin in the mutanttaieprat induces a differential immune response related to protection to the human parasiteTrichinella spiralis

Nava-Castro

Cortes

Eguíbar

et al. 2020

Preprint

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24Taiep rat is a myelin mutant with a progressive motor syndrome characterized by tremor, 25 ataxia, immobility episodes, epilepsy and paralysis of the hindlimbs, accompanied with differential 26 expression of interleukins and their receptors that correlated with the progressive demyelination that 27 characterize this mutant. Thus, the taiep rat is a suitable model to study neuroimmune alterations.28 The aim of this study was to investigate the immune alterations present in the mutant taiep rat during 29 the acute infection with Trichinella spiralis. Our results show that there is an important decrease in 30 the number of intestinal larvae in the taiep rat when compared to the Sprague-Dawley control rats. 31 We also found differences in the percentage of innate and adaptive immune cell profile in the 32 mesenteric lymphatic nodes and the spleen associated to the lack of myelin in the taiep rat. Finally, a 33 clear pro-inflammatory cytokine pattern was seen in the infected taiep rat, which may explain the 34 decrease in larvae number. These results sustain the theory that neuroimmune interaction is a 35 fundamental process capable of modulating the immune response, particularly against the parasite 36 Trichinella spiralis in a model of progressive demyelination that could be an important mechanism in 37 autoimmune diseases and parasite infection. 39Author summary 40 The complex communication among the brain and the immune system may be certainly 41 altered during an infection and may be determinant in the resolution of this. We analyze the immune 42 response to a parasite in a rat model in which a demyelinization process occur naturally and found 43 that parasite loads were reduced when comparing with control subjects and this was accompanied to 44 changes in the systemic immune response.3 45 Introduction 46The interaction of the nervous, endocrine and immune systems is crucial in the maintenance 47 of homeostasis in vertebrates and it is absolutely vital in mammals [1]. Moreover, hormones and 48 neurotransmitters present in the immune cell microenvironment can restrict their autonomy, probably 49 by acting on receptors of these neuroendocrine factors [2]. Therefore, efficient communication 50 among these three systems implies the existence of afferent and efferent pathways, constituting a 51 complex feedback system that regulates an adequate response in base of different insults. 52Alterations of this network trigger pathologies that involve all the system components. In 53 recent years, information on the multiple functions of the immune system has expanded remarkably;54 one of these functions has been biological adaptation through elimination of pathogens and foreign 55 cells from the organism [3]. All functions require delicate control systems, which will allow 56 adaptation of the organism to different physiological and pathological situations, which will face it a 57 longer life. To meet this end, interaction with nervous and endocrine systems of the organism is 58 necessary [3]. This interaction is const...

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Characterization of the spontaneous and gripping-induced immobility episodes ontaiep rats

Cited by 17 publications

References 27 publications

Sleep, Plasticity and the Pathophysiology of Neurodevelopmental Disorders: The Potential Roles of Protein Synthesis and Other Cellular Processes

Sleep, Plasticity and the Pathophysiology of Neurodevelopmental Disorders: The Potential Roles of Protein Synthesis and Other Cellular Processes

Juvenile Taiep rats have shorter dendritic trees in the dorsal field of the hippocampus without spatial learning disabilities

The lack of myelin in the mutanttaieprat induces a differential immune response related to protection to the human parasiteTrichinella spiralis

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