Characterization of the synergistic effect of insulin and transferrin and the regulation of their receptors on a human colon carcinoma cell line

Watkins, Linda F.; Lewis, Laurie R.; Levine, Alan E.

doi:10.1002/ijc.2910450227

Cited by 95 publications

(53 citation statements)

References 27 publications

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“…44 Growth factor signaling is frequently observed in colon cancer. [45][46][47][48] Animals on a HFD expressed higher levels of colonic leptin mRNA and protein than those eating a diet with a normal amount of fat. IR protein expression was also higher in the colons of the obese HFD animals, although a statistical significance was not found.…”

Section: Discussionmentioning

confidence: 99%

Effects of diet-induced obesity on colitis-associated colon tumor formation in A/J mice

et al. 2011

Int J Obes

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Objective: Studies have indicated that obesity is associated with a higher risk of colorectal cancer. This study was performed to determine the effect of diet-induced obesity on the formation of azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon tumors and to identify adiposity-related mechanisms. Methods: Male A/J mice were placed on either a high-fat diet (HFD; 45% of total calories from fat) or a normal diet (ND; 15% of calories from fat) for 12 weeks. To induce colon tumors, AOM was administered at a dose of 10 mg/kg body weight, followed by two cycles of DSS supply. Results: Study results indicated that the HFD group had twofold higher numbers of colonic tumors, as compared with the ND group. The HFD group also had significantly increased body weight and epididymal fat weight, which were associated with increases of serum insulin, insulin-like growth factor-1, leptin, epididymal fat pad leptin mRNA and colonic leptin receptor (Ob-R) mRNA. Animals on HFD showed higher expressions of Ob-R, insulin receptor, phosphorylated Akt, phosphorylated extracellular signal-regulated kinases, Bcl-xL and Cyclin D1 proteins in the colon. Conclusion:The results suggest that HFD-induced obesity facilitates colon tumor formation, possibly by regulating downstream targets of circulating adiposity-related factors via receptor-mediated signaling of the phosphatidylinositol 3-kinase/Akt pathway.

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Section: Discussionmentioning

confidence: 99%

Effects of diet-induced obesity on colitis-associated colon tumor formation in A/J mice

et al. 2011

Int J Obes

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“…Mechanistic studies have been pointed at insulin-like growth factors (IGFs). Insulin acts as a growth factor for colonic mucosal cells and it has been shown to possess promoting effects in in vitro and in animal cancer studies (Koenuma et al, 1989;Watkins et al, 1990;Bjork et al, 1993;Tran et al, 1996). Insulin has the ability to stimulate IGFs which are important mitogens, necessary for the cell to progress from G1 to the S phase of the cell cycle (Aaronson, 1991).…”

Section: Glycemic Index In Chronic Disease Ls Augustin Et Almentioning

confidence: 99%

Glycemic index in chronic disease: a review

et al. 2002

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Aim: The intent of this review is to critically analyze the scientific evidence on the role of the glycemic index in chronic Western disease and to discuss the utility of the glycemic index in the prevention and management of these disease states. Background: The glycemic index ranks foods based on their postprandial blood glucose response. Hyperinsulinemia and insulin resistance, as well as their determinants (eg high energy intake, obesity, lack of physical activity) have been implicated in the etiology of diabetes, coronary heart disease and cancer. Recently, among dietary factors, carbohydrates have attracted much attention as a significant culprit, however, different types of carbohydrate produce varying glycemic and insulinemic responses. Low glycemic index foods, characterized by slowly absorbed carbohydrates, have been shown in some studies to produce beneficial effects on glucose control, hyperinsulinemia, insulin resistance, blood lipids and satiety. Method: Studies on the short and long-term metabolic effects of diets with different glycemic indices will be presented and discussed. The review will focus primarily on clinical and epidemiological data, and will briefly discuss in vitro and animal studies related to possible mechanisms by which the glycemic index may influence chronic disease.

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“…The main factor causing increased risk of colon cancer in DM is hyperinsulinemia [1,2]. Insulin in vitro is a significant growth factor for colonic mucosa cells and has a mitogenic effect on colon carcinoma cells [1][2][3]. Insulin-like growth factor-1 (IGF-I) inhibits apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…Both these hormones are known to promote cellular growth, proliferation, and protooncogene expression [1][2][3]. In addition, acromegaly is associated with an increased prevalence of abnormal glucose tolerance, and hyperinsulinemia due to insulin resistance [4].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and recurrence rate of colonic lesions in acromegalic patients

et al. 2010

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AbstractAcromegaly is associated with an increased prevalence of colonic polyps. The aim of this study was to evaluate the prevalence and recurrence rate of colonic polyps in acromegalic patients. Ninety-six acromegalic patients and 100 irritable bowel syndrome patients (IBS) were enrolled in the study. Twenty patients who were cured exclusively by surgery, and 20 patients that could not be hormonally controlled were re-examined colonoscopically after 36 months. Twenty-nine of 96 acromegalic patients (30.2%) had colonic polyps. In the IBS group, 10 (10.0%) had colonic polyps. The prevalence of colonic polyps was significantly higher in acromegaly. The group of acromegalic patients with and without polyps did not differ significantly with regard to plasma GH, IGF-I, fasting insulin levels and glycemic status. The presence of colonic polyps was correlated with increased patient age and male gender. We did not observe a difference in terms of polyp recurrence frequencies in the patients cured by surgery compared to uncontrolled patients. Acromegalic patients have a higher prevalence of colonic polyps than that of control subjects. We could not identify any factors that could predict polyps within the acromegalic patients - but age and male sex.

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Characterization of the synergistic effect of insulin and transferrin and the regulation of their receptors on a human colon carcinoma cell line

Cited by 95 publications

References 27 publications

Effects of diet-induced obesity on colitis-associated colon tumor formation in A/J mice

Effects of diet-induced obesity on colitis-associated colon tumor formation in A/J mice

Glycemic index in chronic disease: a review

Prevalence and recurrence rate of colonic lesions in acromegalic patients

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