Characterization of the systemic disease and ocular signs induced by experimental infection with Chlamydia psittaci in cats

TerWee, Julie A.; Sabara, Marta; Kokjohn, Katrina; Sandbulte, Jim; Frenchick, P.J.; Dreier, Kimberly

doi:10.1016/s0378-1135(97)00185-5

Cited by 48 publications

(37 citation statements)

References 44 publications

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“…In the present study, conjunctivitis first appeared on PID 5 to 7 in most cats, reached a peak from PID 7 to 10, and then tended to recover, with some exceptions in which it persisted until PID 28. This accords with the typical course of experimental feline C. felis infection reported by several authors [5,8,13,15]. Most naturally infected cats which suffer from chlamydial conjunctivitis exhibit unilateral conjunctivitis [3,9,15]; however, the cats used in this study exhibited bilateral conjunctivitis.…”

supporting

confidence: 90%

“…Experimental inoculation with C. felis produces conjunctivitis, mild rhinitis and fever of relatively late onset in cats [5,6,13]. In the present study, conjunctivitis first appeared on PID 5 to 7 in most cats, reached a peak from PID 7 to 10, and then tended to recover, with some exceptions in which it persisted until PID 28.…”

supporting

confidence: 52%

“…Yan et al reported that the rate of prevalence of C. felis antibodies was 45.5% in stray cats and 12.3% in pet cats [18]. These reports suggest widespread chlamydophila infected in cats in Japan.Cats experimentally infected with C. felis developed conjunctivitis, ocular discharges and fever, and this organism has been isolated from some tissues of experimentally infected cats [5,6,13,15]. However, the time course of the disease and of the spread of the organism in the bodies of infected cats are not known clearly.…”

mentioning

confidence: 99%

“…Cats experimentally infected with C. felis developed conjunctivitis, ocular discharges and fever, and this organism has been isolated from some tissues of experimentally infected cats [5,6,13,15]. However, the time course of the disease and of the spread of the organism in the bodies of infected cats are not known clearly.…”

mentioning

confidence: 99%

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Experimental Infection of Cats with Chlamydophila felis.

Masubuchi

Nosaka

Iwamoto

et al. 2002

The Journal of Veterinary Medical Science

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ABSTRACT. Cats experimentally infected with a British isolate of Chlamydophila felis (C. felis), B166 strain, by droplet into the eye and nose developed conjunctivitis, mild rhinitis and fever. The chlamydophila were first isolated from conjunctiva, nictitating membrane and then from lung, tonsil, liver, spleen, kidney, nasal and vaginal swabs and blood. These results indicate that C. felis B166 strain first infected and replicated in the conjunctiva and nictitating membrane in cats with symptoms which were mostly limited to conjunctivitis, and then pervaded the whole body by bacteremia. KEY WORDS: bacteremia, Chlamydophila felis, experimental infection.J. Vet. Med. Sci. 64(12): 1165-1168, 2002 The disease caused by Chlamydophila felis (C. felis) is clinically characterized by sneezing and coughing, accompanied by mucopurulent ocular and nasal discharges in cats [1]. Nowadays, C. felis is primarily considered an ocular pathogen with or without rhinitis in cats rather than a pulmonary pathogen [3,9,16].There have been a few reports of seroepidemiological investigation of feline chlamydiosis in Japan [4,7,10,18]. Mochizuki et al. reported that C. felis was found in 26.9% of diseased cats with conjunctivitis and rhinits [7]. Yan et al. reported that the rate of prevalence of C. felis antibodies was 45.5% in stray cats and 12.3% in pet cats [18]. These reports suggest widespread chlamydophila infected in cats in Japan.Cats experimentally infected with C. felis developed conjunctivitis, ocular discharges and fever, and this organism has been isolated from some tissues of experimentally infected cats [5,6,13,15]. However, the time course of the disease and of the spread of the organism in the bodies of infected cats are not known clearly.In this report, we describe the characteristics of clinical disease produced by C. felis after ocular and intranasal exposure. The distribution of C. felis in the bodies of cats was also examined by isolation and immunohistological and pathological examinations.C. felis B166 strain used in this experiment was isolated from a cat with conjunctivitis in the United Kingdom in 1984 [14].Twenty-six specific pathogen free (SPF) cats 2 to 6 months old were obtained from a colony maintained on an SPF animal farm. The SPF status of the cats was verified by the culturing of conjunctival swabs in embryonated hens' eggs for chlamydia, CRFK cells for virus, mycoplasma liquid media for mycoplasma, and thioglycolate media for bacteria, and the samples were all negative for these agents. The cats were kept in individual cages, fed commercial dry cat food and supplied water properly. The cats were randomly divided into 11 groups of two or four cats each. Two control cats were kept in a separate room. The experiments were performed according to our institutional guidelines for animal experimentation.Twenty-five microliters of suspension containing 10 3.0 ELD 50 (50% embryo lethal dose) of virulent, egggrown feline C. felis B166 strain were inoculated by droplet into the eye and nose of a cat. The ELD 5...

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supporting

confidence: 90%

supporting

confidence: 52%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Experimental Infection of Cats with Chlamydophila felis.

Masubuchi

Nosaka

Iwamoto

et al. 2002

The Journal of Veterinary Medical Science

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“…Most of the chlamydial strains of feline origin were isolated from cases of conjunctivitis [2,5,8,10], and conjunctivitis has been recognized as one of the most documented clinical signs in cats. However, experimental C. psittaci infection to kittens produces fever, lethargy, lameness, and reduction in weight gain besides ocular signs [11]. In the present study, 2 of 8 strains were isolated from nasal swabs and 5 of 6 strains were isolated from conjunctival swabs with upper respiratory signs.…”

mentioning

confidence: 52%

Isolation of Chlamydia psittaci from Domestic Cats with Oculonasal Discharge in Japan.

Iwamoto

Masubuchi

Nosaka

et al. 2001

The Journal of Veterinary Medical Science

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ABSTRACT. Eight strains of Chlamydia psittaci were isolated in Japan from the nasal and conjunctival swabs of six household cats using the L929 cell line of mouse fibroblast origin. The isolates were identified as C. psittaci on the basis of the formation of characteristic inclusion bodies in the cell culture detected by Giemsa stain and immunofluorescence. Comparison of nucleotide sequences of the ompA gene amplified from the three isolates with the published sequence of feline FEPN strain of C. psittaci showed almost 100% homology.

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Chlamydial Infections

Sykes¹

2004

Feline Medicine and Therapeutics

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Characterization of the systemic disease and ocular signs induced by experimental infection with Chlamydia psittaci in cats

Cited by 48 publications

References 44 publications

Experimental Infection of Cats with Chlamydophila felis.

Experimental Infection of Cats with Chlamydophila felis.

Isolation of Chlamydia psittaci from Domestic Cats with Oculonasal Discharge in Japan.

Chlamydial Infections

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