Characterization of the Targeting Accuracy of a Neuronavigation-Guided Transcranial FUS System In Vitro, In Vivo, and In Silico

First-in-human prospective trial of sonobiopsy in high-grade glioma patients using neuronavigation-guided focused ultrasound

“…The aperture of the transducer was 65 mm, and the focal distance was 65 mm (f-number = 1). As reported in our previous study 45 , the axial and lateral full width at half maximums (FWHM) of the FUS transducer were 20 mm and 3.0 mm, respectively. The FUS transducer was integrated with a passive acoustic detector at its center.…”

“…The trajectory was selected using the following criteria: close to 90° incident angle (best effort), focus depth below skin <35 mm (limited by the focal length of our FUS transducer), and avoiding ultrasound beam passing through the ear lobe and eye. A full-wave acoustic simulation using the k-Wave toolbox was performed to estimate the ultrasound pressure field distribution inside the brain and calculate the skull attenuation using methods reported in our previous publication 45 .…”

Generating Patient-Specific Acoustic Simulations for Transcranial Focused Ultrasound Procedures Based on Optical Tracking Information

“…The larger Error Opti,Sim with the skull comprised of 1.1 ± 0.5 mm of axial error which can be attributed to skull-specific effects captured in simulation. Although we did notice minor focal shifts with the presence of the ex vivo skull, other simulation studies of ex vivo and in situ scenarios indicate larger focal shifts may be expected depending on the skull characteristics, brain target, and transducer properties [11], [22], [53]. This study largely focused on the spatial error of the simulation workflow where we used previously validated acoustic parameters [48].…”

Quality assurance for focused ultrasound-induced blood-brain barrier opening procedure using passive acoustic detection

“…A water bladder was attached to the FUS transducer with an inlet and outlet for degassing the water. The output of the FUS transducer was calibrated using a hydrophone (HGL-0200, Onda Corp., Sunnyvale, CA, USA) connected with a pre-amplifier (AG-20X0, Onda Corp., Sunnyvale, CA, USA) in a water tank using our previous established procedure 29 and the acoustic pressure at the FUS transducer focus was measured and reported in this study.…”