Characterization of the three major polymorphic forms and liquid state of tristearin by Raman spectroscopy

Silva, Éric Da; Bresson, Serge; Rousseau, Dérick

doi:10.1016/j.chemphyslip.2008.11.002

Cited by 68 publications

(78 citation statements)

References 36 publications

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“…Solubilized (HYDRATION of drug) form displayed small and broad peak in the phonon region due to the inherent disorder in the sample, while crystalline forms showed distinct, multiple intense peaks arising from a regular periodic arrangement of molecules in crystals and indicative of very ordered and very crystalline in structure. [27] A slight shift in a spectrum occurs when the crystalline form of drug is compared with the solution of drug. Less intense and broadening of peak may be due to electrostatic interaction.…”

Section: Resultsmentioning

confidence: 99%

“…The significant differences seen between the liquid and solid states was due to the freedom of movement of the O-H, C-O and N-H groups in liquid state, which were not prepared in a lattice arrangement of solid. [27] For understanding the spectra have been divided into the fingerprint regions (500-1800 cm −1 ) and CH/OH regions (2500-3500 cm −1 ). Assessment of the spectra shows clear differences between the pure drug and developed formulation.…”

Section: Resultsmentioning

confidence: 99%

“…[ [25][26][27][28][29] A spectral region between 500-1800 cm −1 and 2500-3500 cm −1 was selected for raman analysis of aceclofenac in crystalline and solution forms as shown in Figures 8 and 9.…”

Section: Raman Spectroscopic Analysismentioning

confidence: 99%

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Solanki

2017

AJP

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Context: Water solubility is an important molecular property for successful drug development as it is a key factor governing drug access to biological membranes. The solubilization of poorly water soluble drug by facilitated mixed solvency is presented. Aim: The aim was to develop the injection formulations of the model poorly water-soluble drug. Settings and Design: Trial and error based experimental study. Materials and Methods: Mixed solvency approach was used to solubilize the hydrophobic drug. Mixed solvent system prepared using water-soluble hydrotropes (such as sodium citrate and urea) and water-miscible cosolvents, such as polyethylene glycol (PEG) 200, PEG 300, PEG 400, PEG 600, glycerin, propylene glycol, and ethanol. Drug was characterized using ultraviolet, Fourier Transform infrared (FT-IR), and Raman spectroscopy. Solubilizing power (Φ) and the Gibbs free energy of transfer (ΔG 0 tr) were determined. Various properties of solution such as pH, viscosity, specific gravity, and refractive index were also studied. Results: Desired solubility of drug achieved in a mixed solvent blend AF5, which was more than 200 fold as compared to the solubility in distilled water 0.152 mg/ml. Drug content was found to be more than 98%. FT-IR and Raman spectroscopy results may support intermolecular hydrogen bonding between drug and mixed solvent system. Developed formulation was physically and chemically stable. Conclusion: This technique proved a synergistic enhancement in solubility of a poorly water soluble drug due to mixed solvent effect and produces a stable formulation. Mixed solvency concept may reduce the individual concentration of solubilizers and so reduce their toxicity associated with them.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Solanki

2017

AJP

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“…The rate of crystallization is primarily due to the length of the fatty acid chains in their structure. With longer chains, structures upon cooling exhibit different morphologies and result in changes in SLN stability, shape, size, drug entrapment efficiency and drug release profiles [13][14][15]. These effects are observed upon cooling of the lipid melt, at the beginning of SLN formation.…”

Section: Effect Of Lipid On Particle Size Diametermentioning

confidence: 95%

“…They share the same space with free fatty acids and diglycerides as they all affect surface solubility and have the ability to form stable monolayers [12,13]. Triglycerides are solid-state fats and consist of 3 different polymorphic forms upon crystallization ( Table 2).…”

Section: Effect Of Lipid On Particle Size Diametermentioning

confidence: 99%

SLNs can Serve as the New Brachytherapy Seed: Determining Influence of Surfactants on Particle Size of Solid Lipid Microparticles and Development of Hydrophobised Copper Nanoparticles for Potential Insertion

Mistry¹,

Sarker²

2016

J Chem Eng Process Technol

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Solid lipid nanoparticles (SLNs) or technically speaking, larger solid lipid microparticles are emerging as a noninvasive technique for drug-delivery, carrying forward advantages of conventional nanostructured systems and eliminating their drawbacks. This study involves the analysis of solid lipid microparticles generated via hot high-shear homogenization technique with tristearin as the main lipid component and phosphate buffer (pH 7.00) as the aqueous phase (phase volume 0.2). This study aims to identify the effects of the chosen lipid, and four non-ionic surfactants (Tween®20, Tween®80, Lutrol F68 and Lutrol F127) on particle size of solid lipid microparticles. Samples generating particle sizes of less than 200 nm were further analysed via SEM to determine morphological characteristics of SLNs. SLN composition is crucial as it determines various chemical and physical properties of the particle itself. Firstly, selection of lipids is key, as it the major component of the particle. Lipids display different polymorphic transitions upon crystallization affecting loading efficiency, drug distribution, drug loading, particle size, particle shape and overall stability. Secondly, selection of surfactants is vital as they overcome stability problems with reducing surface tension, particle aggregation and steric interactions. The aim of this study was to determine the optimal functioning surfactant concentration that would produce particle sizes less than 200 nm. SLNs generated in this study displayed a reduced particle size (90-150 nm) when using 2% w/v Tween®80 plus 5:1 F68; higher molecular weight surfactant, with a low molecular weight poloxamer. Based on previous research, these results can be explained via the surfactant characteristics in solution. The length of the fatty acid chains associated with Tween®20 and 80 provide a potential behavioural pattern on the SLN; longer chains surrounding the SLN structure increase stability of the particle but also increase particle size. Poloxamer use is that of a co-surfactant, fulfilling what Tween® fails to complete. In which higher molecular weight poloxamers can potentially explain the large particle size as the longer PEO terminal chains protrude from the particle after its insertion.

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Raman Spectroscopy for the Study of Molecular Order, Thermodynamics, and Solid–Liquid Transitions in Triacylglycerols

Silva

Rousseau

2001

Handbook of Vibrational Spectroscopy

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The use of Raman spectroscopy for the study of the molecular order in triglycerides is explored, with emphasis placed on three key spectroscopic fingerprints: (i) the CH stretching region at 3000–2700 cm −1 , (ii) the ester carbonyl (CO) stretching region at 1780–1700 cm −1 , and the CC stretching region at ∼1200–1100 cm −1 . Triglyceride polymorph and phase‐dependent changes related to the aliphatic chain and glycerol backbone conformation and packing, as well as changes in local environment, are ascertained on the basis of shifts in these bands. In particular, the ester carbonyl stretching region demonstrates clear differences between triglycerides polymorphs, as changes are seen in the number, stretching frequency, and size of the modes present. Besides, phase transition enthalpies are extracted from the Raman spectra of triglycerides studied. This chapter demonstrates that Raman spectroscopy is a viable tool for the characterization of triglycerides.

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Characterization of the three major polymorphic forms and liquid state of tristearin by Raman spectroscopy

Cited by 68 publications

References 36 publications

Untitled

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SLNs can Serve as the New Brachytherapy Seed: Determining Influence of Surfactants on Particle Size of Solid Lipid Microparticles and Development of Hydrophobised Copper Nanoparticles for Potential Insertion

Raman Spectroscopy for the Study of Molecular Order, Thermodynamics, and Solid–Liquid Transitions in Triacylglycerols

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