Characterization of the virulence of <i>Mycobacterium avium</i> complex (MAC) isolates in mice

Pedrosa, Jorge; Florido, Mário; Kunze, Z. M.; Castro, Albert; Portaels, Françoise; McFadden, Johnjoe; Silva, M. T.; Appelberg, Rui

doi:10.1111/j.1365-2249.1994.tb06127.x

Cited by 77 publications

(37 citation statements)

References 21 publications

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“…Furthermore, it was found that most bird isolates had similar IS901 patterns. These isolates were also shown to be strikingly more virulent than AIDS patient isolates in BALB/c mice (142,204). Evidence that a more pathogenic subset of M. avium exists has been advanced numerous times since, leading some to simply divide M. avium isolates into those that are IS901 ϩ and those that are IS901 Ϫ (68).…”

Section: Genetic Methods To Detect Is Elementsmentioning

confidence: 99%

Mycobacterium avium in the Postgenomic Era

2007

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SUMMARY The past several years have witnessed an upsurge of genomic data pertaining to the Mycobacterium avium complex (MAC). Despite clear advances, problems with the detection of MAC persist, spanning the tests that can be used, samples required for their validation, and the use of appropriate nomenclature. Additionally, the amount of genomic variability documented to date greatly outstrips the functional understanding of epidemiologically different subsets of the organism. In this review, we discuss how postgenomic insights into the MAC have helped to clarify the relationships between MAC organisms, highlighting the distinction between environmental and pathogenic subsets of M. avium. We discuss the availability of various genetic targets for accurate classification of organisms and how these results provide a framework for future studies of MAC variability. The results of postgenomic M. avium study provide optimism that a functional understanding of these organisms will soon emerge, with genomically defined subsets that are epidemiologically distinct and possess different survival mechanisms for their various niches. Although the status quo has largely been to study different M. avium subsets in isolation, it is expected that attention to the similarities and differences between M. avium organisms will provide greater insight into their fundamental differences, including their propensity to cause disease.

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Section: Genetic Methods To Detect Is Elementsmentioning

confidence: 99%

Mycobacterium avium in the Postgenomic Era

2007

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“…Mice were infected with M. avium strain 724, which has been characterized previously (31) and was a kind gift from T. Ulrichs, Max Planck Institute for Infectious Biology, Berlin, Germany. Following 3 weeks of growth in Dubos broth at 37°C, mycobacteria were suspended in sterile saline containing 0.05% Tween 20 and kept at Ϫ80°C until they were used.…”

Section: Animalsmentioning

confidence: 99%

I/St Mice Hypersusceptible toMycobacterium tuberculosisAre Resistant toM. avium

et al. 2007

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We previously demonstrated that mice of the I/St strain are extremely susceptible to Mycobacterium tuberculosis, as well as to the taxonomically distant intracellular bacteria Chlamydia pneumoniae and Salmonella enterica. To broaden our knowledge about the control of susceptibility to intracellular pathogens, we studied the infection caused by Mycobacterium avium virulent strain 724 in a panel of inbred mouse strains and found that I/St mice are resistant to M. avium. By comparing I/St mice with B6 mice, we demonstrated that (i) B6 mice are much more susceptible to infection caused by M. avium in terms of bacterial multiplication in the lung tissue and severity of lung pathology; (ii) in B6 mice but not in I/St mice infection leads to prolonged leukocyte infiltration of the lung tissue, development of necrotic lung granulomata, and lethality; and (iii) the unfavorable infectious course in B6 mice is accompanied by elevated production of gamma interferon, tumor necrosis factor alpha, and especially interleukin-12 in the lungs. Importantly, M. avium-resistant I/St mice carry a functional r allele of the Slc11a1 (formerly Nramp1) gene, while B6 mice have the Slc11a1 s genotype. Segregation genetic analysis of (I/St × B6) F2 hybrids demonstrated that susceptibility or resistance to infection caused by M. avium largely depended upon the Slc11a1 genotype and that other genetic traits had a relatively weak influence. This close-to-monogenic pattern differs sharply from the host control of many other intracellular bacterial infections, for which the involvement of numerous quantitative trait loci has been ubiquitously observed.

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“…MAC is not pathogenic for guinea pigs and rats . Pedrosa et al (1994) described the investigation focused on the virulence of various MAC isolates in naturally susceptible BALB/c mice. Gross lesions that develop after the infection with MAC members differ from lesions caused by the MTC members in the majority of animal species.…”

Section: Avium Complex Membersmentioning

confidence: 99%

Tuberculous and tuberculoid lesions in free living small terrestrial mammals and the risk of infection to humans and animals: a review

Škorič¹,

Shitaye²,

Halouzka³

et al. 2007

Vet. Med. - Czech

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ABSTRACT:The present study describes pathogenesis and morphology of tuberculous and tuberculoid lesions in small terrestrial mammals, above all, in rodents. The most serious infectious agents that cause tuberculous and tuberculoid lesions in these animals are also cited. Besides others, the diseases caused by pathogenic mycobacteria that are members of Mycobacterium tuberculosis and M. avium complexes, M. lepraemurium, tularaemia, brucellosis and salmonellosis are included in the present study.

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Characterization of the virulence of Mycobacterium avium complex (MAC) isolates in mice

Cited by 77 publications

References 21 publications

Mycobacterium avium in the Postgenomic Era

Mycobacterium avium in the Postgenomic Era

I/St Mice Hypersusceptible toMycobacterium tuberculosisAre Resistant toM. avium

Tuberculous and tuberculoid lesions in free living small terrestrial mammals and the risk of infection to humans and animals: a review

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