Characterization of Time-Varying Properties and Regional Strains in Myocardial Ischemia

Liao, Jingsheng; Li, John K.‐J.; Metaxas, Dimitris N.

doi:10.1023/b:care.0000015103.43455.10

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…7 This compensating mechanism is necessary to augment the reduced SV. The resulting dilation of the LV, particularly during systole when left ventricular pressure (LVP) becomes higher, is often detected in clinical imaging 8 with angiography, MRI, or ultrasound.…”

Section: Hemodynamic Parameters Governing Left Ventricular Function Imentioning

confidence: 99%

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Left Ventricle–Arterial System Interaction in Heart Failure

Atlas

2015

Clin Med Insights Cardiol

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Ejection fraction (EF) has been viewed as an important index in assessing the contractile state of the left ventricle (LV). However, it is frequently inadequate for the diagnosis and management of heart failure (HF), as a significant subset of HF patients have been found to have reduced EF (HFrEF) whereas others have preserved EF (HFpEF). It should be noted that the function of the LV is dependent on both preload and afterload, as well as its intrinsic contractile state. Furthermore, stroke volume (SV) is dependent on the properties of the arterial system (AS). Thus, the LV-arterial system interaction plays an important role in those patients with HF. This aspect is investigated through the analysis of the specific parameters involved in the coupling of the LV and AS. This includes contractility and the systolic/diastolic indices of the LV. Furthermore, AS afterload parameters such as vascular stiffness and arterial compliance, and their derived coupling coefficient, are also investigated. We conclude that those parameters, which relate to LV structural changes, are most appropriate in quantifying the LV–AS interaction.

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Section: Hemodynamic Parameters Governing Left Ventricular Function Imentioning

confidence: 99%

“…T s (11) while T is the cardiac period in seconds (ie, T = t s + t d ), the effective E a can be rewritten, as in (8),…”

Section: Hemodynamic Parameters Governing the As In Normal And Hf Conmentioning

confidence: 99%

Left Ventricle–Arterial System Interaction in Heart Failure

Atlas

2015

Clin Med Insights Cardiol

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“…These regulation tasks are performed by the coronary vessels of different sizes with different time constants, which complicates the transient behavior of the coronary system in response to the dynamic change of the physiological equilibrium point. Currently, most of the coronary modeling research concentrated on one specific aspect of the coronary dynamics or pathology (e.g., Li, 2004a,b;Liao et al, 2003) mentioned above, such that the complex behavior of the coronary system can be simplified with well-controlled animal experiment. Integrated models also exist which combine different modeling results to produce more realistic coronary flow pattern.…”

Section: Introductionmentioning

confidence: 99%

Modeling of the Coronary Circulatory System

Liao¹,

Li²

2005

Cardiovasc Eng

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The dynamics of the coronary system is complicated by its dependence on the mechanical properties of the coronary vessels, the anatomical distribution of the vasculature, the biochemical and neurohormonal regulation, and the effect of myocardial contraction. Several types of coronary system models were proposed, focusing on different aspects of coronary system behavior and supported by different animal experiment methodologies. The lumped models were based on well-controlled coronary pressure-flow measurement and simplified assumptions. They are probably most useful for interpreting hemodynamic data measured in modern catheterizaton labs. Anatomical models, with the advancement in morphometric research, coronary angiography, and video densitometry, provided branching pattern, geometric distribution, and distensibility of coronary vessels. Mathematical description based on vascular waterfall theory, intramyocardial pump model, and time varying elastance concept provided some explanation of the interaction between the coronary system and myocardial contraction. More accurate models would include intramyocardial pressure, microcirculatory hemodynamics, coronary flow regulation, and myocardial oxygen supply and consumption. The combination of different models, may lead to a more comprehensive understanding of the coronary system.

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Quantitative cardiology and computer modeling analysis of heart failure in systole and in diastole

Kaya

Kerkhof

2018

Computers in Biology and Medicine

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Characterization of Time-Varying Properties and Regional Strains in Myocardial Ischemia

Cited by 5 publications

References 38 publications

Left Ventricle–Arterial System Interaction in Heart Failure

Left Ventricle–Arterial System Interaction in Heart Failure

Modeling of the Coronary Circulatory System

Quantitative cardiology and computer modeling analysis of heart failure in systole and in diastole

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