Characterization of Trabecular Bone Microarchitecture and Mechanical Properties Using Bone Surface Curvature Distributions

Abstract

Understanding bone surface curvatures is crucial for the advancement of bone material design, as these curvatures play a significant role in the mechanical behavior and functionality of bone structures. Previous studies have demonstrated that bone surface curvature distributions could be used to characterize bone geometry and have been proposed as key parameters for biomimetic microstructure design and optimization. However, understanding of how bone surface curvature distributions correlate with bone microstructure and mechanical properties remains limited. This study hypothesized that bone surface curvature distributions could be used to predict the microstructure as well as mechanical properties of trabecular bone. To test the hypothesis, a convolutional neural network (CNN) model was trained and validated to predict the histomorphometric parameters (e.g., BV/TV, BS, Tb.Th, DA, Conn.D, and SMI), geometric parameters (e.g., plate area PA, plate thickness PT, rod length RL, rod diameter RD, plate-to-plate nearest neighbor distance NNDPP, rod-to-rod nearest neighbor distance NNDRR, plate number PN, and rod number RN), as well as the apparent stiffness tensor of trabecular bone using various bone surface curvature distributions, including maximum principal curvature distribution, minimum principal curvature distribution, Gaussian curvature distribution, and mean curvature distribution. The results showed that the surface curvature distribution-based deep learning model achieved high fidelity in predicting the major histomorphometric parameters and geometric parameters as well as the stiffness tenor of trabecular bone, thus supporting the hypothesis of this study. The findings of this study underscore the importance of incorporating bone surface curvature analysis in the design of synthetic bone materials and implants.