Characterization of TRH/GnRH-like peptides in the sea cucumber, Holothuria scabra, and their effects on oocyte maturation

Chaiyamoon, Arada; Tinikul, Ruchanok; Nontunha, Nittiya; Chaichotranunt, Supakant; Poomtong, Tanes; Sobhon, Prasert; Tinikul, Yotsawan

doi:10.1016/j.aquaculture.2019.734814

Cited by 10 publications

(3 citation statements)

References 29 publications

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“…Finally, the evolutionary origin of the effect of TRH is poorly understood. It appears that TRH or TRH-type peptides have the capacity to modulate food-intake in many vertebrates and in non-vertebrate deuterostomes [195][196][197][198]. Thus, the control of food-intake by TRH-type peptides might have appeared early, even before vertebrate evolution.…”

Section: Discussionmentioning

confidence: 99%

Thyrotropin Releasing Hormone and Food-Intake in Mammals: An Update

Vargas,

Castro Tron,

Charli

et al. 2024

Preprint

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Thyrotropin releasing hormone (TRH; pGlu-His-Pro-NH2) is an intercellular signal produced mainly by neurons. Among the multiple pharmacological effects of TRH, that on food-intake is not well understood. We review data that show that peripheral injection of TRH generally produces a transient anorexic effect, discuss the pathways that might initiate this effect, and explain its short half-life. In addition, central administration of TRH can produce anorexic or orexigenic effects, depending on the site of injection, that are likely due to interaction with TRH receptor 1. Anorexic effects are most notable when TRH is injected into the hypothalamus and the nucleus accumbens, while the orexigenic effect has only been detected by injection into the brain stem. Functional evidence suggests that TRH neurons that are prime candidate vectors for TRH action on food-intake include the caudal raphe nuclei projecting to the dorsal motor nucleus of the vagus, and possibly TRH neurons from the tuberal lateral hypothalamus projecting to the tuberomammillary nuclei. For other TRH neurons, the anatomical or physiological context and impact of TRH in each synaptic domain are still poorly understood. The manipulation of TRH expression in well-defined neuron types will facilitate the discovery of its role in food-intake control in each anatomical scene.

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Section: Discussionmentioning

confidence: 99%

Thyrotropin Releasing Hormone and Food-Intake in Mammals: An Update

Vargas,

Castro Tron,

Charli

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Finally, the evolutionary origin of the effect of TRH is poorly understood. It appears that TRH or TRH-type peptides have the capacity to modulate food intake in many vertebrates and in non-vertebrate deuterostomes [ 194 , 195 , 196 , 197 ]. Thus, the control of food intake by TRH-type peptides might have appeared early, even before vertebrate evolution.…”

Section: Discussionmentioning

confidence: 99%

Thyrotropin-Releasing Hormone and Food Intake in Mammals: An Update

Vargas,

Castro Tron,

Rodríguez Rodríguez

et al. 2024

Metabolites

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Thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2) is an intercellular signal produced mainly by neurons. Among the multiple pharmacological effects of TRH, that on food intake is not well understood. We review studies demonstrating that peripheral injection of TRH generally produces a transient anorexic effect, discuss the pathways that might initiate this effect, and explain its short half-life. In addition, central administration of TRH can produce anorexic or orexigenic effects, depending on the site of injection, that are likely due to interaction with TRH receptor 1. Anorexic effects are most notable when TRH is injected into the hypothalamus and the nucleus accumbens, while the orexigenic effect has only been detected by injection into the brain stem. Functional evidence points to TRH neurons that are prime candidate vectors for TRH action on food intake. These include the caudal raphe nuclei projecting to the dorsal motor nucleus of the vagus, and possibly TRH neurons from the tuberal lateral hypothalamus projecting to the tuberomammillary nuclei. For other TRH neurons, the anatomical or physiological context and impact of TRH in each synaptic domain are still poorly understood. The manipulation of TRH expression in well-defined neuron types will facilitate the discovery of its role in food intake control in each anatomical scene.

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“…In echinoderms, the recent development of RNA high-throughout sequencing technology has allowed strong advances in the identification and characterization of neuropeptides in adults [ 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ]. Neuropeptides in adult echinoderms have been proven to play important roles in muscle contractility, feeding and reproduction [ 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ]. In comparison with adults, little is known about neuropeptide localization and function during the larval stages of most echinoderms, especially in holothuroids.…”

Section: Introductionmentioning

confidence: 99%

Nervous System Development and Neuropeptides Characterization in Embryo and Larva: Insights from a Non-Chordate Deuterostome, the Sea Cucumber Apostichopus japonicus

Zheng

Cong

Liu

et al. 2022

Biology

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Here, we described the complex nervous system at five early developmental stages (blastula, gastrula, auricularia, doliolaria and pentactula) of a holothurian species with highly economic value, Apostichopus japonicus. The results revealed that the nervous system of embryos and larvae is mainly distributed in the anterior apical region, ciliary bands or rings, and the feeding and attachment organs, and that serotonergic immunoreactivity was not observed until the embryo developed into the late gastrula; these are evolutionarily conserved features of echinoderm, hemichordate and protostome larvae. Furthermore, based on available transcriptome data, we reported the neuropeptide precursors profile at different embryonic and larval developmental stages. This analysis showed that 40 neuropeptide precursors present in adult sea cucumbers were also identified at different developmental stages of embryos and larvae, and only four neuropeptide precursors (SWYG precursor 2, GYWKDLDNYVKAHKT precursor, Neuropeptide precursor 14-like precursor, GLRFAmprecursor-like precursor) predicted in adults were absent in embryos and larvae. Combining the quantitative expression of ten specific neuropeptide precursor genes (NPs) by qRT-PCR, we revealed the potential important roles of neuropeptides in embryo development, feeding and attachment in A. japonicus larvae. In conclusion, this work provides novel perspectives on the diverse physiological functions of neuropeptides and contributes to understanding the evolution of neuropeptidergic systems in echinoderm embryos and larvae.

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Characterization of TRH/GnRH-like peptides in the sea cucumber, Holothuria scabra, and their effects on oocyte maturation

Cited by 10 publications

References 29 publications

Thyrotropin Releasing Hormone and Food-Intake in Mammals: An Update

Thyrotropin Releasing Hormone and Food-Intake in Mammals: An Update

Thyrotropin-Releasing Hormone and Food Intake in Mammals: An Update

Nervous System Development and Neuropeptides Characterization in Embryo and Larva: Insights from a Non-Chordate Deuterostome, the Sea Cucumber Apostichopus japonicus

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