Characterization of triple reassortant H1N1 influenza A viruses from swine in Ohio

Yassine, Hadi M.; Khatri, Mahesh; Zhang, Y.J.; Lee, C.W.; Byrum, Beverly; O'Quin, Jeanette; Smith, Kathleen A.; Saif, Y. M.

doi:10.1016/j.vetmic.2009.04.028

Cited by 42 publications

(38 citation statements)

References 39 publications

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“…Transmission of influenza viruses from pigs to humans has been reported occasionally, but most cases result in mild infections rarely resulting in death ( Robinson et al 2007, Howden et al 2009, Yassine et al 2009, Adeola et al. 2010, Song et al 2010, Forgie et al 2011, CDC 2012, Gray et al 2012, Williamson et al 2012).…”

Section: Discussionmentioning

confidence: 99%

“…2010, Song et al 2010, Forgie et al 2011, CDC 2012, Gray et al 2012, Williamson et al 2012). Swine workers and their family members are at increased risk of contracting swine influenza virus infections ( Olsen et al 2002, Myers et al 2006, Gray et al 2007, Robinson et al 2007, Yassine et al 2009, Beaudoin et al 2012, CDC 2012, Wong et al 2012). In this study, we were unable to document human flu-like illnesses during the period of sample collection.…”

Section: Discussionmentioning

confidence: 99%

“…Swine viruses bind equally well to both NeuAcα2,6Gal and NeuAcα2,3Gal (with a slightly higher binding affinity for NeuAcα2,6Gal), therefore they are able to infect both human and avian cells [for review see Ma et al (2009) ]. Evidence exists demonstrating transmission of influenza viruses from humans to pigs (Howden et al 2009, Adeola et al 2010, Song et al 2010, Forgie et al 2011, Gray et al 2012, Williamson et al 2012) as well as from pigs to humans (Robinson et al 2007, Yassine et al 2009, CDC 2012). Influenza A virus transmission between humans and swine often results in the emergence of new strains with the potential of spreading among both populations (Myers et al.…”

mentioning

confidence: 99%

“…Influenza A virus transmission between humans and swine often results in the emergence of new strains with the potential of spreading among both populations (Myers et al. 2007, Yassine et al 2009, Xu et al 2011, Yu et al 2011). …”

mentioning

confidence: 99%

“…Studies have shown that swine workers are at an increased risk of contracting an influenza A infection from pigs (Olsen et al 2002, Myers et al 2006, Gray et al 2007, Yassine et al 2009, Beaudoin et al 2012, CDC 2012). Biosecurity and biocontainment measurements might help prevent the spread of pathogens, including influenza viruses from pigs to humans and vice-versa .…”

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confidence: 99%

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Influenza A virus infection of healthy piglets in an abattoir in Brazil: animal-human interface and risk for interspecies transmission

Amorim

Fornells

Reis

et al. 2013

Mem. Inst. Oswaldo Cruz

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Asymptomatic influenza virus infections in pigs are frequent and the lack of measures for controlling viral spread facilitates the circulation of different virus strains between pigs. The goal of this study was to demonstrate the circulation of influenza A virus strains among asymptomatic piglets in an abattoir in Brazil and discuss the potential public health impacts. Tracheal samples (n = 330) were collected from asymptomatic animals by a veterinarian that also performed visual lung tissue examinations. No slaughtered animals presented with any noticeable macroscopic signs of influenza infection following examination of lung tissues. Samples were then analysed by reverse transcription-polymerase chain reaction that resulted in the identification of 30 (9%) influenza A positive samples. The presence of asymptomatic pig infections suggested that these animals could facilitate virus dissemination and act as a source of infection for the herd, thereby enabling the emergence of influenza outbreaks associated with significant economic losses. Furthermore, the continuous exposure of the farm and abattoir workers to the virus increases the risk for interspecies transmission. Monitoring measures of swine influenza virus infections and vaccination and monitoring of employees for influenza infection should also be considered. In addition regulatory agencies should consider the public health ramifications regarding the potential zoonotic viral transmission between humans and pigs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Influenza A virus infection of healthy piglets in an abattoir in Brazil: animal-human interface and risk for interspecies transmission

Amorim

Fornells

Reis

et al. 2013

Mem. Inst. Oswaldo Cruz

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Genetic characterization of swine influenza viruses (H3N2) isolated from Minnesota in 2006–2007

et al. 2011

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Triple-reassortant (TR) H3N2 swine influenza viruses (SIV) are a major cause of respiratory disease in swine worldwide, causing considerable morbidity and mortality. Continuous surveillance of circulating SIV strains is imperative for effective control and prediction of new emerging strains with interspecies transmission potential. The current study characterized SIV isolates from commercial swine population in USA (2006-2007). Nine isolates were completely sequenced, and the molecular evolution of all gene segments was analyzed. Phylogenetic analysis of the nine H3N2 viruses indicated that these strains belonged to cluster-IV of the human/swine/avian TR genotype, grouping with H3N2 viruses of turkey origin, while forming a separate sub-lineage from those of human and avian origin strains. Ten amino acid changes were observed at the major antigenic sites of HA1 region compared to the cluster-III reference strain, with differences in glycosylation sites. All the nine strains were antigenically related to the cluster-IV turkey strain than the cluster-III reference strain. The results of this study suggest that contemporary TR H3N2 strains circulating in North America share the same genetic constellation, thus maintaining the gene pool without any further event of genetic reassortment unlike swine-origin pandemic strain A/California/04/2009/H1N1. These findings strongly support the need for continuous surveillance and monitoring of genetic changes in SIV, to identify evolving strains that might pose a threat to human or animal health.

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Diseases of the Respiratory System

2017

Veterinary Medicine

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Characterization of triple reassortant H1N1 influenza A viruses from swine in Ohio

Cited by 42 publications

References 39 publications

Influenza A virus infection of healthy piglets in an abattoir in Brazil: animal-human interface and risk for interspecies transmission

Influenza A virus infection of healthy piglets in an abattoir in Brazil: animal-human interface and risk for interspecies transmission

Genetic characterization of swine influenza viruses (H3N2) isolated from Minnesota in 2006–2007

Diseases of the Respiratory System

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