1993
DOI: 10.1016/s0021-9258(19)36902-9
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Characterization of two forms of human factor Va with different cofactor activities.

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Cited by 78 publications
(38 citation statements)
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“…It was also reported (Rosing et al, 1993) that plasma factor V is heterogeneous and yields two forms of factor Va (Va 1 and Va 2 ) after activation that bind with different affinities to negatively charged membranes.…”
Section: Effect Of Phospholipid On Inactivation Of Factor Va 1 Andmentioning
confidence: 94%
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“…It was also reported (Rosing et al, 1993) that plasma factor V is heterogeneous and yields two forms of factor Va (Va 1 and Va 2 ) after activation that bind with different affinities to negatively charged membranes.…”
Section: Effect Of Phospholipid On Inactivation Of Factor Va 1 Andmentioning
confidence: 94%
“…Phospholipids were obtained from Avanti Polar Lipids, Pelham, AL. Small unilamellar phospholipid vesicles were prepared as described before (Rosing et al, 1993). S2238, S2366, and I2581 were supplied by Chromogenix, Mo ¨lndal, Sweden.…”
Section: Methodsmentioning
confidence: 99%
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“…In human plasma, FV circulates as a mixture of two isoforms, FV1 (glycosylated) and FV2 (not glycosylated) that have slightly different molecular weights because of partial N-linked glycosylation at N2181. This leads to differences in membrane-binding behavior between FV1 and FV2 (Rosing et al, 1993;Hoekema et al, 1997, Nicolaes et al, 1999. Also, glycosylation at N2181 has been proposed to modulate the FV expression levels (Nicolaes et al, 1999).…”
Section: Introductionmentioning
confidence: 99%