Characterization of Two Novel Polyomaviruses of Birds by Using Multiply Primed Rolling-Circle Amplification of Their Genomes

Johne, Reimar; Wittig, W; Fernández-de-Luco, Daniel; Höfle, Úrsula; Müller, Hermann

doi:10.1128/jvi.80.7.3523-3531.2006

Cited by 68 publications

(64 citation statements)

References 46 publications

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“…The sequence of the APV involved in this case was 99% identical to that of a novel APV (tentatively designated as finch polyomavirus) in the region of the genome examined in this study. This novel virus was detected in a Eurasian bullfinch (Pyrrhula pyrrhula griseiventris) (Johne et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Mycobacterium genavenseand avian polyomavirus co-infection in a European Goldfinch (Carduelis carduelis)

et al. 2007

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Section: Resultsmentioning

confidence: 99%

Mycobacterium genavenseand avian polyomavirus co-infection in a European Goldfinch (Carduelis carduelis)

et al. 2007

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“…Using a strategy that exploited the circular nature of polyomavirus genomes (Johne et al, 2006), we recovered the entire genome of the virus detected in two Myotis species. Analysis of the complete sequence of the viral genomes recovered from three animals revealed an as-yet undescribed polyomavirus.…”

Section: Viruses In Bats Of Canadamentioning

confidence: 99%

Detection of polyoma and corona viruses in bats of Canada

Misra

Dumonceaux

Dubois³

et al. 2009

Journal of General Virology

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Several instances of emerging diseases in humans appear to be caused by the spillover of viruses endemic to bats, either directly or through other animal intermediaries. The objective of this study was to detect, identify and characterize viruses in bats in the province of Manitoba and other regions of Canada. Bats were sampled from three sources: live-trapped Myotis lucifugus from Manitoba, rabies-negative Eptesicus fuscus, M. lucifugus, M. yumanensis, M. septentrionalis, M. californicus, M. evotis, Lasionycteris (L.) noctivagans and Lasiurus (Las.) cinereus, provided by the Centre of Expertise for Rabies of the Canadian Food Inspection Agency (CFIA), and L. noctivagans, Las. cinereus and Las. borealis collected from a wind farm in Manitoba. We attempted to isolate viruses from fresh tissue samples taken from trapped bats in cultured cells of bat, primate, rodent, porcine, ovine and avian origin. We also screened bat tissues by PCR using primers designed to amplify nucleic acids from members of certain families of viruses. We detected RNA of a group 1 coronavirus from M. lucifugus (3 of 31 animals) and DNA from an asyet undescribed polyomavirus from female M. lucifugus (4 of 31 animals) and M. californicus (pooled tissues from two females).

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“…These viruses exhibit a range of pathogenicity and have been associated with both benign and malignant disease (4,47,48,59). Like PVs, PyVs infect humans and a variety of mammalian and avian species, with 14 PyV types completely genomically characterized to date (15,25,35). The mammalian PyVs display a narrow host range and do not productively infect other species.…”

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confidence: 99%

A Novel Virus Detected in Papillomas and Carcinomas of the Endangered Western Barred Bandicoot ( Perameles bougainville ) Exhibits Genomic Features of both the Papillomaviridae and Polyomaviridae

Woolford

Rector

Ranst

et al. 2007

J Virol

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Conservation efforts to prevent the extinction of the endangered western barred bandicoot (Perameles bougainville) are currently hindered by a progressively debilitating cutaneous and mucocutaneous papillomatosis and carcinomatosis syndrome observed in captive and wild populations. In this study, we detected a novel virus, designated the bandicoot papillomatosis carcinomatosis virus type 1 (BPCV1), in lesional tissue from affected western barred bandicoots using multiply primed rolling-circle amplification and PCR with the cutaneotropic papillomavirus primer pairs FAP59/FAP64 and AR-L1F8/AR-L1R9. Sequencing of the BPCV1 genome revealed a novel prototype virus exhibiting genomic properties of both the Papillomaviridae and the Polyomaviridae. Papillomaviral properties included a large genome size (ϳ7.3 kb) and the presence of open reading frames (ORFs) encoding canonical L1 and L2 structural proteins. The genomic organization in which structural and nonstructural proteins were encoded on different strands of the double-stranded genome and the presence of ORFs encoding the nonstructural proteins large T and small t antigens were, on the other hand, typical polyomaviral features. BPCV1 may represent the first member of a novel virus family, descended from a common ancestor of the papillomaviruses and polyomaviruses recognized today. Alternatively, it may represent the product of ancient recombination between members of these two virus families. The discovery of this virus could have implications for the current taxonomic classification of Papillomaviridae and Polyomaviridae and can provide further insight into the evolution of these ancient virus families.

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Characterization of Two Novel Polyomaviruses of Birds by Using Multiply Primed Rolling-Circle Amplification of Their Genomes

Cited by 68 publications

References 46 publications

Mycobacterium genavenseand avian polyomavirus co-infection in a European Goldfinch (Carduelis carduelis)

Mycobacterium genavenseand avian polyomavirus co-infection in a European Goldfinch (Carduelis carduelis)

Detection of polyoma and corona viruses in bats of Canada

A Novel Virus Detected in Papillomas and Carcinomas of the Endangered Western Barred Bandicoot ( Perameles bougainville ) Exhibits Genomic Features of both the Papillomaviridae and Polyomaviridae

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