Characterization of Urine-Derived Stem Cells from Patients with End-Stage Liver Diseases and Application to Induced Acute and Chronic Liver Injury of Nude Mice Model

Urine-derived stem cells; A robust platform for generating native or engineered autologous Extracellular Vesicles

“…Cell transplants with autologous MSCs have shown higher success rates for engraftment and are not expected lead to any alloimmunity (45,46). MSCs derived from diseased and older individuals could potentially be less potent, but Zhang et al showed that USCs derived from various end-stage liver disease patients had the same potency in reducing acute and chronic liver injury in a murine model (47). On the contrary to cell transplantation, treatment with non-self EVs does not seem to be as immunogenic ( 48), yet prolonged treatment with allogenic EVs could lead to immune clearance, reduced circulation time, and lowered therapeutic effects, as previously reported (49).…”

miR-126-3p-loaded small extracellular vesicles secreted by urine-derived stem cells released from a phototriggered imine crosslink hydrogel could enhance vaginal epithelization after vaginoplasty

“…Stem cells, a new therapeutic option for regenerative medicine, have been demonstrated to accelerate epithelization of wounds, although the molecular mechanisms remain unknown [ 32 ]. Compared with MSCs, autologous hUSCs have more clinical therapeutic value for vaginal tissue repair due to their desirable biological properties such as abundant sources, painless accession, easy collection, and low immunogenicity in vitro [ 33 – 35 ]. sEVs have been shown to have a similar function to that of parent cells by carrying the same biological factors [ 36 ].…”

Urine-derived stem cells: Promising advancements and applications in regenerative medicine and beyond

“…In a liver characterization study aimed at assessing the biosignature of end-stage liver disease patient-derived USCs, independent of the underlying liver disease, the transplantation of these cells demonstrated partial repair of liver injury [ 99 ]. While associations of USCs with the gastrointestinal tract require further exploration, one study has suggested that USCs may attenuate inflammation in a rat model of inflammatory bowel disease (IBD) by suppressing the Th1/Th17 immune response [ 100 ].…”