Characterization of Vaginal and Endometrial Microbiome in Patients With Chronic Endometritis: A Pilot Study.

Abstract

Comparative study of CD138 immunostain and microbiome of the female reproductive tract (vaginal and endometrial) in the diagnosis of chronic endometritis. A pilot study from May 2017 to May 2019. Instituto Bernabeu fertility clinic. Cohort study with sixty patients undergoing assisted reproductive treatment. The vaginal and endometrial microbiome was analyzed by mass sequencing of the V3V4 region of 16S rRNA. Bioinformatics analysis was performed using QIIME2 and MicrobiomeAnalyst packages. Alpha, beta diversity and taxonomic characterization were compared with positive and negative CD138 groups for