Characterization of variations in IL23A and IL23R genes: possible roles in multiple sclerosis and other neuroinflammatory demyelinating diseases

Li, Fei-Feng; Zhu, Xidong; Yan, Peng; Jin, Meihua; Yue, Hui; Zhang, Qiong; Fu, Jin; Liu, Shulin

doi:10.18632/aging.101058

Cited by 21 publications

(19 citation statements)

References 40 publications

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“…We were conducted the statistical analyses and Hardy-Weinberg equilibrium tests of the study participants using SPSS software (version 19.0) [43] and Plink (version 1.9) [44,45] . And as previously study showen, using the online software SNPSpD and Haploview software, we were calculated the experiment-wide significance threshold and the matrix of mpirwise linkage-disequilibrium (LD) correlation [46] .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of VEGFA gene variants for possible roles in cerebral infarction diseases

Zhang

Guo

et al. 2019

Preprint

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Background: Cerebral infarction is one of the most common cerebral small vessel diseases. Many angiogenesis relevanted factors have special roles on the diseases pathogenesis. The vascular endothelial growth factor A (VEGFA) is the most prominent stimulating molecule factor for angiogenesis. So, we want to evaluate the correlation between VEGFA gene and this disease in this work. Methods: The VEGFA gene was sequenced for 400 cerebral infarction patients and 600 normal controls. SPSS software (version 19.0), Plink (version 1.9), Haploview software and online software SNPSpD were used for the statistical analyses and Hardy-Weinberg equilibrium tests. Results: We found variants rs10434, rs3025040, rs185218985, rs199971699, rs574579489, rs735286 and rs833061 within or near the VEGFA gene. The genetic heterozygosity of rs10434, rs3025040, rs735286 and rs833061 was very high. Statistical analysis showed that the variants rs10434 (P=0.041) and rs735286 (P=0.034) in the gene were associated with the risk of cerebral infarction diseases in the Chinese Han population. Conclusions: VEGFA variants rs10434 and rs735286 were associated with the risk of cerebral infarction diseases in the Chinese Han population.

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Section: Discussionmentioning

confidence: 99%

Evaluation of VEGFA gene variants for possible roles in cerebral infarction diseases

Zhang

Guo

et al. 2019

Preprint

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“…Overall OC genetics correlation analysis was also conducted. As previously reported, the statistical analyses and Hardy-Weinberg equilibrium tests of the patients and control populations were conducted [29,[32][33][34].…”

Section: Snp Genotyping and Statistical Analysismentioning

confidence: 99%

Associations of CXCL1 gene 5’UTR variations with ovarian cancer

Guo

Chen

et al. 2020

J Ovarian Res

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Background: There are about 2.4 hundred thousand new cases and 1.5 hundred thousand deaths of ovarian cancer (OC) annually in the world. Chronic inflammation is a risk factor for OC. C-X-C motif chemokine ligand 1 (CXCL1) defects may facilitate inflammation and transactivate EGFR in ovarian cancer, but the precise haplotypes associated with the potential diseases remained largely unknown. In this work, we characterized CXCL1 gene variations to elucidate their possible associations with OC.Methods: We analyzed the CXCL1 gene for 300 OC patients with 400 healthy participants as controls. The statistical analyses and Hardy-Weinberg equilibrium tests of the patients and control populations were conducted using the SPSS software (version 19.0) and Plink (version 1.9).Results: The variants rs11547681, rs201090116, rs199791199, rs181868085, rs4074 and rs1814092 within or near the CXCL1 gene were characterized. The genetic heterozygosity of rs11547681 and rs4074 was very high. Statistical analysis showed that the variant rs11547681 in the gene was closely associated with the risk of OC in the Chinese Han population, although this variant was not associated with FIGO stages or pathological grades of the patients. Conclusions: Rs11547681 in CXCL1 gene was associated with the risk of OC in the Chinese Han population.

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“…Considering that IL-23 cytokine has an important role in the atherosclerosis process, the gene that encodes this cytokine could be a candidate for genetic association studies. Genetic studies have associated the rs2066808, rs2371494, and rs11575248 polymorphisms in the IL-23A gene with susceptibility to multiple sclerosis 121 . Alternatively, the rs11171806 polymorphism in the IL-23A gene has been significantly associated with susceptibility to Graves' disease in Han Chinese 122 , but not in the northern Italian population 123 .…”

Section: Il-23a Genementioning

confidence: 99%

Innate Immunity in Coronary Disease. The Role of Interleukin-12 Cytokine Family in Atherosclerosis

Posadas-Sánchez

Vargas‐Alarcón

2018

RIC

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Atherosclerosis is a chronic, progressive, and multifactorial disease modulated by genetic and environmental factors. In recent years, the paradigm that explained atherosclerosis as resulting from a complex interaction between factors not accessible to medical intervention, and modifiable risk factors has changed. In this paradigm, alterations in lipid metabolism were the pivotal concept of atherosclerosis as a chronic degenerative disease. In the last years, an increasing number of observations have shown that the innate and adaptive immune responses to lipoprotein deposition and oxidation in the arterial wall significantly influence atherosclerosis. Currently, it is well recognized that the pathogenesis of atherosclerosis and its complications involves the inflammatory process, which includes the participation of several cytokines. Besides the classic cytokines involved in this process, the role of the interleukin-12 (IL-12) family has been recently demonstrated. This review describes our current understanding about the role of the family of IL-12 in atherosclerosis considering the participation of the genes that encode these cytokines in the genetic susceptibility to developing this disease.

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Characterization of variations in IL23A and IL23R genes: possible roles in multiple sclerosis and other neuroinflammatory demyelinating diseases

Cited by 21 publications

References 40 publications

Evaluation of VEGFA gene variants for possible roles in cerebral infarction diseases

Evaluation of VEGFA gene variants for possible roles in cerebral infarction diseases

Associations of CXCL1 gene 5’UTR variations with ovarian cancer

Innate Immunity in Coronary Disease. The Role of Interleukin-12 Cytokine Family in Atherosclerosis

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