Characterization of verruciform xanthoma by <i>in situ</i> hybridization and immunohistochemistry

Iamaroon, Anak; Vickers, Robert A.

doi:10.1111/j.1600-0714.1996.tb00285.x

Cited by 53 publications

(48 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The etiology is unknown, and most cases are not related to human papilloma virus (HPV) infection. The presence of HPV in the epithelial cells has been demonstrated in only two reported lesions in the oral mucosa [15] and scrotum [16].…”

Section: Discussion Esophagusmentioning

confidence: 99%

Non-gastric Gastrointestinal Xanthomas: Case Series and Literature Review

Arco

Sánchez

Aceñero

2016

JGLD

View full text Add to dashboard Cite

Gastrointestinal xanthomas are infrequent non-neoplastic lesions characterized by the accumulation of foam cells in the lamina propria. They are commonly seen in association with dyslipidemia, chemotherapy or radiotherapy, and infections in immunosuppressed patients. However, no clear connection to hyperlipidemia has been found. They occur more frequently in the stomach, and are very rare in the small bowel and esophagus. We identified all cases of non-gastric xanthoma or xanthomatosis reported in the English literature by searching the PubMed database and retrospectively reviewed the clinical, endoscopic, and histopathologic features of the 11 cases of non-gastric gastrointestinal xanthomas diagnosed in our hospital. Nine lesions were located in the large bowel, one in the duodenum and one in the esophagus. All xanthomas were small (<5 mm) sessile polyps except the esophageal xanthoma, which measured 13 mm. Two cases in the large bowel and the case in the small bowel were multiple. Most patients with large bowel xanthomas had hypercholesterolemia, unlike esophageal and small bowel cases. The esophageal lesion occurred in a patient with a history of partial fundoplication due to gastroesophageal reflux disease and the small bowel case was associated to chronic atrophic gastritis with intense activity. In our search of the English literature, we found 19 cases of xanthoma or xanthomatosis in the esophagus, 13 cases in the small bowel and 61 cases in the large bowel. In conclusion, gastrointestinal xanthomas, other than the gastric ones, are rare, and are usually incidental findings. Abbreviations: AIDS: Acquired immunodeficiency syndrome; CESD: Cholesterol ester storage disease; ChT: Chemotherapy; CMV: Cytomegalovirus; GERD: Gastroesophageal reflux disease; HCL: Hypercholesterolemia; HCV: Hepatitis C virus; HPV: Human papilloma virus; MAI: Mycobacterium avium intracellulare; PCR: Polymerase chain reaction; RT: Radiotherapy.

show abstract

Section: Discussion Esophagusmentioning

confidence: 99%

Non-gastric Gastrointestinal Xanthomas: Case Series and Literature Review

Arco

Sánchez

Aceñero

2016

JGLD

View full text Add to dashboard Cite

show abstract

“…The size of oral VX lesions normally ranges between 0.2 to 2.0 cm 3,4,[16][17] with exception of a large lesion measuring 4.0 x 1.5 cm reported by Graff et al 19 . With regard to appearance, Neville et al, described that this may vary from "white and verruciform" to "red and ulcerated".…”

Section: Collaboratorsmentioning

confidence: 99%

“…The treatment of choice was to perform excisional biopsy of the two lesions, with excellent prognosis up to the present date. Treatment was performed by surgical excision, in which recurrence is extremely rare [16][17] . An interesting finding in the present case was the fact that the patient presented two oral lesions.…”

Section: Collaboratorsmentioning

confidence: 99%

Verruciform xanthoma: case report

Monteiro

Furuse

Cé

et al. 2016

RGO, Rev. Gaúch. Odontol.

View full text Add to dashboard Cite

Verruciform xanthoma is a rare, benign lesion, with a papillary aspect, asymptomatic, sessile, white colored, and well-demarcated, that RESUMOO xantoma verruciforme é uma lesão muito rara, benigna, com aspecto papilar, indolor, séssil, localizada, principalmente, na gengiva e mucosa alveolar, podendo ocorrer na pele e genitália. O grau de queratinização da superfície influencia na cor, variando de branca a vermelha. Histopatologicamente é caracterizado pela presença de macrófagos com citoplasma espumoso (células de xantoma) acumulados e confinados ao tecido conjuntivo papilar. Criptas invaginadas alternam-se com extensões papilares. As cristas epiteliais alongadas estendem-se para a lâmina própria em profundidade uniforme. Sua etiologia e patogênese são desconhecidas, apesar de várias hipóteses terem sido sugeridas, como trauma local ou viral. O diagnóstico diferencial pode incluir o papiloma escamoso, o carcinoma escamoso papilar e o condiloma acuminado. O tratamento é a excisão conservadora e o prognóstico é excelente. O objetivo deste trabalho foi relatar um caso clínico de xantoma verruciforme localizado na gengiva inserida mostrando seu aspecto clínico e histopatológico.Termos de indexação: Xantomatose. Diagnóstico. Patologia bucal.

show abstract

“…1,10,11,17,18 Evaluation for HPV in VX has been studied and has included types 6, 7, 11, 12, 16 to 19, 31, 33, 35, 37, 44 to 47, 53, 54, and 58. 6,13,[21][22][23] While most studies failed to show evidence of HPV, 1 study 13 demonstrated by immunohistochemical analysis a positive reaction in the upper epidermal keratinocytes, which was confirmed by electron microscopy and by PCR, which also detected HPV-DNA 6a. Another investigation 22 demonstrated by immunohistochemical analysis a positive reaction with polyclonal antisera against papilloma virus.…”

Section: Commentmentioning

confidence: 99%