Characterization of virulent Klebsiella variicola recovered from inpatients with intestinal and extraintestinal infections between 1987 and 1999

Valiatti, Tiago Barcelos; Santos, Fernanda dos; Nunes, Pedro Henrique Soares; Cayô, Rodrigo; Gales, Ana Cristina; Gomes, Tânia A. T.

doi:10.1016/j.diagmicrobio.2021.115482

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…Brazil is a continental country bordering most South American countries, and it is characterized by six major biomes, namely Amazon, Cerrado, Caatinga, Pantanal, Atlantic Forest, and Pampa, which is supposed to have the greatest biodiversity in the world [11]. In this country, KpSC has already been incriminated in nosocomial infections, including high-risk clones presenting multidrug resistance mainly due to the presence of carbapenemase genes, such as bla NDM and bla KPC [4,[12][13][14][15][16][17]. Moreover, virulent and multidrug-resistant strains from natural environments and animals have also been reported [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Genomics of Klebsiella pneumoniae Species Complex Reveals the Circulation of High-Risk Multidrug-Resistant Pandemic Clones in Human, Animal, and Environmental Sources

2022

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The Klebsiella species present a remarkable genetic and ecological diversity, being ubiquitous in nature. In particular, the Klebsiella pneumoniae species complex (KpSC) has emerged as a major public health threat in the world, being an interesting model to assess the risk posed by strains recovered from animals and the environment to humans. We therefore performed a genomic surveillance analysis of the KpSC using every public genome in Brazil, aiming to show their local and global relationships, and the connectivity of antibiotic resistance and virulence considering human, animal, and environmental sources. The 390 genomes from distinct sources encompassed the K. pneumoniae, Klebsiella quasipneumoniae subsp. quasipneumoniae, Klebsiella quasipneumoniae subsp. similipneumoniae, Klebsiella variicola subsp. variicola, Klebsiella variicola subsp. tropica, and Klebsiella grimontii species and subspecies. K. pneumoniae harbored dozens of antibiotic resistance genes, while most of the genomes belong to the high-risk pandemic CC258 occurring in humans, animals, and the environment. In K. pneumoniae ST11, a high prevalence of the virulence determinants yersiniabactin, colibactin, and T6SS was revealed in association with multi-drug resistance (MDR), including carbapenem resistance. A diversity of resistance genes is carried by plasmids, some shared between strains from different STs, regions, and sources. Therefore, here were revealed some factors driving the success of KpSC as a pathogen.

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Section: Introductionmentioning

confidence: 99%

Genomics of Klebsiella pneumoniae Species Complex Reveals the Circulation of High-Risk Multidrug-Resistant Pandemic Clones in Human, Animal, and Environmental Sources

2022

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Klebsiella , Enterobacter , Citrobacter , and Selected Other Enterobacteriaceae

Das,

Pierce,

Frank

2023

ClinMicroNow

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The genera Klebsiella , Enterobacter , Citrobacter , and Cronobacter are commonly encountered in clinical laboratories and cause a range of infections in humans, including bacteremia, meningitis, wound infections, and infections of the respiratory and urinary tracts. This chapter contains information not only on the taxonomy, detection, and identification of these genera but also on the global issue of antimicrobial resistance, which is especially pertinent to this group of organisms. Klebsiella pneumoniae is a significant pathogen in both community and hospital settings. Klebsiella granulomatis is the agent of donovanosis or granuloma inguinale, a disease characterized by painless, slowly progressive, vascular genital ulcers. Enterobacter spp. are opportunistic pathogens that are found in the natural environment in habitats such as water, sewage, vegetables, and soil. They are also commensal bacteria in the human gastrointestinal tract. The detection of antimicrobial‐resistant organisms by laboratories is a critical step required for appropriate management of patients and infection prevention and control efforts.

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Decreased susceptibility to imipenem and ceftazidime in early virulent Raoultella spp. strains retrieved from human intestinal infections

et al. 2022

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Characterization of virulent Klebsiella variicola recovered from inpatients with intestinal and extraintestinal infections between 1987 and 1999

Cited by 4 publications

References 11 publications

Genomics of Klebsiella pneumoniae Species Complex Reveals the Circulation of High-Risk Multidrug-Resistant Pandemic Clones in Human, Animal, and Environmental Sources

Genomics of Klebsiella pneumoniae Species Complex Reveals the Circulation of High-Risk Multidrug-Resistant Pandemic Clones in Human, Animal, and Environmental Sources

Klebsiella , Enterobacter , Citrobacter , and Selected Other Enterobacteriaceae

Decreased susceptibility to imipenem and ceftazidime in early virulent Raoultella spp. strains retrieved from human intestinal infections

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