Characterization of γδ T cells in patients with non-small cell lung cancer

Bao, Yi; Li, Guo; Mo, Juanfen

doi:10.3892/ol.2017.6191

Cited by 14 publications

(16 citation statements)

References 43 publications

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“…40 A lower frequency of circulating γδT cells was observed in NSCLC patients than in healthy controls. 41 However, we found increased levels of γδT cells in peripheral blood of patients with NSCLC. In addition, γδT cells expressed comparable levels of IFN-γ but higher levels of IL-17 in NSCLC patients compared with NC.…”

Section: Discussionmentioning

confidence: 55%

“…They can also produce diverse cytokines (IFN‐γ, tumor necrosis factor [TNF]‐α, and IL‐17) and chemokines (RANTES, IP‐10, lymphotactin) in response to specific antigens . A lower frequency of circulating γδT cells was observed in NSCLC patients than in healthy controls . However, we found increased levels of γδT cells in peripheral blood of patients with NSCLC.…”

Section: Discussionmentioning

confidence: 68%

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Long‐term prognostic significance of interleukin‐17‐producing T cells in patients with non‐small cell lung cancer

Wang

Chen

et al. 2019

Cancer Science

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The presence of interleukin (IL)‐17‐producing T cells has recently been reported in non‐small cell lung cancer (NSCLC) patients. However, the long‐term prognostic significance of these populations in NSCLC patients remains unknown. In the present study, we collected peripheral blood from 82 NSCLC patients and 22 normal healthy donors (NC). Percentages of IL‐17‐producing CD4+T (Th17), CD8+T (Tc17) and γδT cells (γδT17) were measured to determine their association with clinical outcomes and overall survival (OS) in NSCLC. All NSCLC patients were followed up until July 2018. Median follow‐up time was 13.5 months (range 1‐87 months). The 3‐ and 5‐year survival rate was 27% and 19.6%, respectively. We found that Th17 cells and γδT17 cells were significantly increased, whereas Tc17 cells were markedly decreased in patients with NSCLC compared with those in NC. In addition, Th17 cells were significantly positively associated with T helper type 1 cells (Th1), whereas γδT17 cells were significantly negatively associated with γδT + interferon (IFN)‐γ+ cells. High percentages of peripheral Tc17 cells were significantly associated with favorable 5‐year OS (P = .025), especially in patients with early TNM stage (P = .016). Furthermore, high percentages of peripheral Th17 cells were positively associated with favorable 5‐year OS in patients with late TNM stage (P = .002). However, no significant association was observed between γδT17 cells and OS, regardless of the TNM stage. In conclusion, our findings suggest that enhanced Th17 and reduced Tc17 cells in the peripheral blood could be a significant predictor of a favorable prognosis for NSCLC patients.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 68%

Long‐term prognostic significance of interleukin‐17‐producing T cells in patients with non‐small cell lung cancer

Wang

Chen

et al. 2019

Cancer Science

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“…An important issue for cancer immunotherapy is the immune-profiling of the different tumor-derived γδ T cell subsets. Analysis of γδ TIL by flow cytometry revealed an inversion of the Vδ1/Vδ2 ratio in tumors including melanoma, 55,69 colorectal cancer, 56,70 squamous cell carcinoma, 71 esophageal tumors, 72 non-small-cell lung cancer, 73 PDAC, 63 and ovarian cancer. 58,74 The inversion of the Vδ1/Vδ2 ratio is demonstrated by a high percentage of Vδ1 γδ T cells and a reduced percentage of Vδ2 γδ T cells within TIL compared to peripheral blood lymphocytes (PBL) of the same donors.…”

Section: Distribution Of Tumor-infiltrating γδ T Cell Subsetsmentioning

confidence: 99%

Tumor resistance mechanisms and their consequences on γδ T cell activation

Wesch

Kabelitz

Oberg

2020

Immunological Reviews

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The immune system has successfully developed various mechanisms to recognize and respond to foreign antigens including tumor antigens. The different mechanisms include recognition of microbe (pathogen) and damage-associated molecular patterns by cells of the innate and adaptive immune systems including γδ T cells, missing-self and induced-self recognition by Natural Killer (NK) cells, antigen-specific recognition by αβ T cells and B cells, and selective recognition of non-proteinaceous antigens by γδ T cells. Cancer is a devastating disease and a leading cause of death worldwide. The difficulties of effective tumor-specific T cell responses are summarized as follows (a) low frequency of tumor antigen-specific T cells, (b) weak immunogenicity of tumor antigens, (c) downregulation of antigen-presenting human leukocyte antigen

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“…cytokine releasing state (53). In a murine model of Lewis lung carcinoma-derived MPE, IL-10 deficiency led to increased γδ T cell intrapleural proliferation and IL-17a production, reduced MPE volume, and longer survival that was dependent on γδ T cells.…”

Section: Discussionmentioning

confidence: 98%

HMGB1 Promotes Myeloid Egress and Limits Lymphatic Clearance of Malignant Pleural Effusions

et al. 2020

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Pleural effusions, when benign, are attributed to cardiac events and suffusion of fluid within the pleural space. When malignant, lymphatic obstruction by tumor and failure to absorb constitutively produced fluid is the predominant formulation. The prevailing view has been challenged recently, namely that the lymphatics are only passive vessels, carrying antigenic fluid to secondary lymphoid sites. Rather, lymphatic vessels can be a selective barrier, efficiently coordinating egress of immune cells and factors within tissues, limiting tumor spread and immune pathology. An alternative explanation, offered here, is that damage associated molecular pattern molecules, released in excess, maintain a local milieu associated with recruitment and retention of immune cells associated with failed lymphatic clearance and functional lymphatic obstruction. We found that levels of high mobility group box 1 (HMGB1) were equally elevated in both benign and malignant pleural effusions (MPEs) and that limited diversity of T cell receptor expressing gamma and delta chain were inversely associated with these levels in MPEs. Acellular fluid from MPEs enhanced γδ T cell proliferation in vitro, while inhibiting cytokine production from γδ T cells and monocytes as well as restricting monocyte chemotaxis. Novel therapeutic strategies, targeting HMGB1 and its neutralization in such effusions as well as direct delivery of immune cells into the pleural space to reconstitute normal physiology should be considered.

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Characterization of γδ T cells in patients with non-small cell lung cancer

Cited by 14 publications

References 43 publications

Long‐term prognostic significance of interleukin‐17‐producing T cells in patients with non‐small cell lung cancer

Long‐term prognostic significance of interleukin‐17‐producing T cells in patients with non‐small cell lung cancer

Tumor resistance mechanisms and their consequences on γδ T cell activation

HMGB1 Promotes Myeloid Egress and Limits Lymphatic Clearance of Malignant Pleural Effusions

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