Characterization, sulfated modification and bioactivity of a novel polysaccharide from Millettia dielsiana

Wang, Zhonghua; Cai, Tongqiang; He, Xipu

doi:10.1016/j.ijbiomac.2018.05.147

Cited by 27 publications

(12 citation statements)

References 40 publications

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“…Rats treated with Sinomenium acutum have a lower level of inflammatory parameters, such as tumor necrosis factor- α (TNF- α ) and prostaglandin-E2 (PG-E2) [ 14 ]. Millettia dielsiana is a TCM to treat RA and gynecological diseases used as antioxidant, immunomodulatory, and anticoagulant agents [ 15 ]. It can help RA patients relieve muscle aches and pains.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Qiwei Tongbi Oral Liquid in Patients with Stable Long-Standing Rheumatoid Arthritis

Fang

Zhang

2021

BioMed Research International

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Objective. Our study is aimed at investigating the efficacy and safety of Qiwei Tongbi oral liquid in patients with stable long-standing rheumatoid arthritis (RA). Method. 140 patients with stable long-standing RA were recruited into the Qiwei Tongbi oral liquid group or the control group. At study recruitment and after 12 weeks of treatment, their C-reactive protein (CRP) levels, interleukin-6 (IL-6) levels, erythrocyte sedimentation rate (ESR), Health Assessment Questionnaire (HAQ), visual analogue scale (VAS), and Disease Activity Score (DAS) 28 were compared in two groups. Results. Patients in the Qiwei Tongbi oral liquid group had a lower level of CRP, IL-6, VAS scale, and HAQ score compared to patients in the control group (CRP: 3.51 ± 1.57 vs . 5.47 ± 1.72 mg/L, P < 0.001 ; IL-6: 1.62 ± 0.8 vs. 2.19 ± 0.88 pg/mL, P < 0.001 ; VAS scale: 1.59 ± 0.69 vs. 2.66 ± 1.02 , P < 0.001 ; and HAQ score: 1.19 ± 0.46 vs. 1.41 ± 0.50 , P = 0.005 ). The ESR and DAS28 did not reach statistical difference. No damage to liver and kidney functions was observed in both groups. Conclusion. Qiwei Tongbi oral liquid has the tendency to decrease the inflammation levels and pain score and improve patients’ outcomes in patients with stable long-standing RA.

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Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Qiwei Tongbi Oral Liquid in Patients with Stable Long-Standing Rheumatoid Arthritis

Fang

Zhang

2021

BioMed Research International

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“…For antioxidant testing in vivo, we found that MZPS-2 had a remarkable ability to scavenge free radicals (P < 0:01). For anti-inflammation testing in vivo, the results , and 50 μg/mL, respectively); IV, V, and VI: three MPS-2-treated groups (10,25, and 50 μg/mL, respectively). * P < 0:05, * * P < 0:01 versus MC; ## P < 0:01 versus VC; a P < 0:05 versus the other group.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, MZPS-2 could potentially be used as a new zinc supplement, which might have a beneficial effect during the treatment of inflammation or oxidative stress caused by zinc deficiency. Shandong Academy of Sciences (2018QN0028, 2019QN002), Technology Development Foundation of (10,25, and 50 μg/mL, respectively); IV, V, and VI: three MPS-2-treated groups (10,25, and 50 μg/mL, respectively). * P < 0:05, * * P < 0:01 versus MC; ## P < 0:01 versus VC.…”

Section: Discussionmentioning

confidence: 99%

“…Zinc could also induce the organism to produce metallothionein with scavenging free radical activity [43]. (10,25, and 50 μg/mL, respectively); IV, V, and VI: three MPS-2-treated groups (10,25, and 50 μg/mL, respectively). * P < 0:05, * * P < 0:01 versus MC; ## P < 0:01 versus VC.…”

Section: Activities Of Mzps-2 On Lps-stimulated Ros Generationmentioning

confidence: 99%

“…Determination of Triple Helical Structure. The triplehelix structure of MZPS and its fractions were determined via the Congo red method [25]. Aliquots of sample solution (1 mL, 6 mg/mL) were mixed with 1 mL Congo red solution (80 μmol/L).…”

Section: Determination Of Molecularmentioning

confidence: 99%

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Distribution of Zinc in Mycelial Cells and Antioxidant and Anti-Inflammatory Activities of Mycelia Zinc Polysaccharides from Thelephora ganbajun TG-01

Zheng

Zhang

et al. 2020

Oxidative Medicine and Cellular Longevity

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This study demonstrates that Thelephora ganbajun had a strong ability to absorb zinc, and zinc can be compartmentally stored in the small vesicles and mainly accumulated in the form of zinc-enriched polysaccharides (zinc content was 25.0±1.27 mg/g). Mycelia zinc polysaccharides (MZPS) and its fractions were isolated. The main fraction (MZPS-2) with the highest antioxidant activity in vitro was composed of mannose : galacturonic acid : glucose : galactose in a molar ratio of 61.19 : 1 : 39.67 : 48.67, with a weight-averaged molecular weight of 5.118×105 Da. MZPS-2 had both α-pyranose and β-pyranose configuration and had a triple helical conformation. By establishing zebrafish models, we found that MZPS-2 can significantly scavenge free radicals, reduce the generation of reactive oxygen species caused by inflammation, and inhibit the recruitment of neutrophils toward the injury site. Therefore, MZPS-2 exhibited antioxidant and anti-inflammatory effects and can be used as a zinc supplement with specific biological activities to alleviate zinc deficiency complications, such as chronic oxidative stress or inflammation.

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Preparation, characterization and bioactivity of polysaccharide fractions from Sagittaria sagittifolia L.

Zhang

et al. 2020

Carbohydrate Polymers

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Characterization, sulfated modification and bioactivity of a novel polysaccharide from Millettia dielsiana

Cited by 27 publications

References 40 publications

Efficacy and Safety of Qiwei Tongbi Oral Liquid in Patients with Stable Long-Standing Rheumatoid Arthritis

Efficacy and Safety of Qiwei Tongbi Oral Liquid in Patients with Stable Long-Standing Rheumatoid Arthritis

Distribution of Zinc in Mycelial Cells and Antioxidant and Anti-Inflammatory Activities of Mycelia Zinc Polysaccharides from Thelephora ganbajun TG-01

Preparation, characterization and bioactivity of polysaccharide fractions from Sagittaria sagittifolia L.

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