Characterization through scanning electron microscopy and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>μ</mml:mi></mml:math>Fourier transform infrared spectroscopy of microcalcifications present in fine needle aspiration smears

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Section: Infrared Microscopy (µ-Ir)mentioning

confidence: 99%

Metal complexes in cells: from design of catalytic antioxidants to imaging metal ions and designing metal-based probes in X-ray fluorescence and IR-imaging, a multidisciplinary collaborative journey in bioinorganic chemistry and inorganic chemical biology

Policar,

Delsuc,

Bertrand

2024

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“…Among them, we can mention cholesterol in gall bladder [98,99], or monosodium urate causative for gout in joints [101,102]. Finally, some chemical compounds contain calcium but are amorphous, as in the case of amorphous carbonated calcium phosphate which has been identified in different organs like breast [13,103], thyroid [104][105][106] and kid- ney [3,107]. "Crystalline pathology" is thus not really an appropriate definition and "pathologies related to abnormal deposits" may be a better one.…”

Section: On the Definition Of Crystalline Pathologiesmentioning

confidence: 99%

“…We have already investigated biological samples from different organs and parts of the human body, namely kidney [177][178][179][180][181][182][183], prostate [184,185], breast [13,103], thyroid [104][105][106], cartilage [186][187][188][189][190][191][192][193], bone [194][195][196][197], tooth [198], pancreas [199], skin and hairs [53][54][55]147,165,168,[200][201][202][203] and cardiovascular system [140,204,205]. We have also investigated cells [206], mice [207][208][209][210], and medical devices [211,212], as well as chemical compounds identified in k...…”

Section: Characterization By Physicochemical Techniquesmentioning

confidence: 99%

Foreword to microcrystalline pathologies: combining clinical activity and fundamental research at the nanoscale

Bazin¹,

Daudon²,

Frochot³

et al. 2022

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This contribution underlines the key role of physicochemical characterisation techniques in the area of medical research. The starting point centres on the Mid-InfraRed platform located at the Tenon hospital and dedicated to multidisciplinary functional investigations. In the last two decades, we have enhanced this platform by creating a network combining researchers from varied disciplines such as physicists, chemists, and clinicians. The resultant research dynamism is underscored by metrics such as 71 references in Pubmed and 129 in Web of Science, and the high impact of the journals in which we have published (New England Journal of Medicine, Kidney International, Chemical Review. . . ). It is of paramount importance to disseminate these physicochemical techniques among young doctors, and to establish collaborations with appropriate private companies.

“…Over recent decades, there has been considerable interest in the application of such morphoconstitutional models to pathological calcifications in other organs, namely prostate [73,74], thyroid [75][76][77], skin [78], breast [16,79] or joints [80][81][82][83][84][85][86][87].…”

Section: Pathology-induced Nanomaterialsmentioning

confidence: 99%

Nanomaterials in medicine: a concise review of nanomaterials intended to treat pathology, nanomaterials induced by pathology, and pathology provoked by nanomaterials

Bazin¹

2022

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This contribution is a concise review of nanomaterials in medicine, those designed to treat pathology, those which are induced by pathology, and those which provoke pathology. Clearly, there is a vast family of therapeutic and medically relevant nanomaterials, to which numerous excellent journals and books are dedicated. The purpose of the first section is to illustrate the chemical complexity of research into therapeutic nanomaterials and the challenges in their characterisation. The second section treats that family of nanomaterials induced by diverse pathologies, such as metabolic disorders, infection, or cancer. Here, the challenge is to find characterisation techniques able to provide chemical information at the nanometer scale to enable and enhance early medical diagnosis. Finally, various nanomaterials injected into the human body for esthetic purposes are discussed, specifically tattoo inks which can provoke severe pathologies such as skin cancer.