Characterizing anterior cingulate activation in chronic schizophrenia: a group and single‐subject fMRI study

Harrison, Ben J; Yücel, Murat; Fornito, Alexander; Wood, Stephen J.; Seal, Marc L.; Clarke, Kerrie; Pantelis, Christos

doi:10.1111/j.1600-0447.2007.01002.x

Cited by 21 publications

(10 citation statements)

References 45 publications

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“…Consistent with previous fMRI studies (7-20, 22), though not all (21), we observed decreased activation in the MFC in schizophrenia subjects. In general, studies that used the Multi-Source Interference Task, a task combining multiple sources of cognitive interference, have identified fewer differences between schizophrenia and healthy control groups (11, 13).…”

Section: Discussionsupporting

confidence: 93%

Assessments of Function and Biochemistry of the Anterior Cingulate Cortex in Schizophrenia

Reid

Stoeckel

White

et al. 2010

Biological Psychiatry

113

100

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Section: Discussionsupporting

confidence: 93%

Assessments of Function and Biochemistry of the Anterior Cingulate Cortex in Schizophrenia

Reid

Stoeckel

White

et al. 2010

Biological Psychiatry

113

100

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“…40,41 The distribution of executive functions over a wide cerebral network that encompasses subcortical structures and thalamic pathways has been established by extensive imaging research, which included the generation of tasks involving only 1 specific executive process (e.g., set-shifting 1,42 ) and event-related functional MRI studies deconstructing the different stages or elements of complex executive tasks. For example, using modified versions of the WCST, Monchi and colleagues 11 observed a cortical-basal ganglia-thalamic loop after negative feedback, and Lie and colleagues 15 found a neural network including frontoparietal regions and the striatum underlying WCST performance.…”

mentioning

confidence: 99%

Neural correlates of set-shifting: decomposing executive functions in schizophrenia

Wilmsmeier

Ohrmann

Suslow

et al. 2010

jpn

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321Background: Although there is considerable evidence that patients with schizophrenia have impaired executive functions, the neural mechanisms underlying these deficits are unclear. Generation and selection is one of the basic mechanisms of executive functioning. We investigated the neural correlates of this mechanism by means of functional magnetic resonance imaging (fMRI) in patients with schizophrenia and healthy controls. Methods: We used the Wisconsin Card Sorting Test (WCST) in an event-related fMRI study to analyze neural activation patterns during the distinct components of the WCST in 36 patients with schizophrenia and 28 controls. We focused our analyses on the process of set-shifting. After participants received negative feedback, they had to generate and decide on a new sorting rule. Results: A widespread activation pattern encompassing the inferior and middle frontal gyrus, parietal, temporal and occipital cortices, anterior cingulate cortex (ACC), supplementary motor area, insula, caudate, thalamus and brainstem was observed in patients with schizophrenia after negative versus positive feedback, whereas in healthy controls, significant activation clusters were more confined to the cortical areas. Significantly increased activation in the rostral ACC after negative feedback and in the dorsal ACC during matching after negative feedback were observed in schizophrenia patients compared with controls. Controls showed activation in the bilateral dorsolateral prefrontal cortex (Brodmann area 46), whereas schizophrenia patients showed activation in the right dorsolateral prefrontal cortex only. Limitations: All patients were taking neuroleptic medication, which has an impact on cognitive function as well as on dopaminergic and serotonergic prefrontal metabolism. Conclusion: Our data suggest that, in patients with schizophrenia, set-shifting is associated with increased activation in the rostral and dorsal ACC, reflecting higher emotional and cognitive demands, respectively.

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“…Verbal fluency is used as a standard neuropsychological test of language production requiring subjects to generate words in response to cues (10,(15)(16)(17). The functional anatomy of verbal fluency has been characterised in normal subjects (18,19); the cortical regions consistently associated with this task include the left middle and inferior frontal gyri (17,(19)(20)(21)(22)(26)(27)(28), the cingulate gyrus (17,22,25,(28)(29)(30)(31), as well as the right cerebellum and the temporoparietal cortex (17,27,29,31,32). Increased task demand had been associated with increased prefrontal and anterior cingulate gyrus activation in healthy controls (17), while patients with schizophrenia fail to demonstrate this ÔnormalÕ response to the increased task demand (12,17,33).…”

Section: Introductionmentioning

confidence: 99%

An fMRI study of prefrontal dysfunction and symptomatic recovery in schizophrenia

Smee¹,

Krabbendam²,

O’Daly³

et al. 2010

Acta Psychiatrica Scandinavica

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Characterizing anterior cingulate activation in chronic schizophrenia: a group and single‐subject fMRI study

Abstract: These findings challenge existing notions of impaired dAC activation in chronic schizophrenia and suggest that the functional pathophysiology of this medial-wall region should be considered beyond straightforward models of hypoactivation.

Cited by 21 publications

References 45 publications

Assessments of Function and Biochemistry of the Anterior Cingulate Cortex in Schizophrenia

Assessments of Function and Biochemistry of the Anterior Cingulate Cortex in Schizophrenia

Neural correlates of set-shifting: decomposing executive functions in schizophrenia

An fMRI study of prefrontal dysfunction and symptomatic recovery in schizophrenia

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