Characterizing cartilage-specific T1rho MRI for clinical translation and application

Klocke, Noelle

doi:10.17077/etd.lwm4nglx

Cited by 2 publications

(4 citation statements)

References 62 publications

(186 reference statements)

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“…34 While T1rho is sensitive to both T1 and T2 tissue properties, the biochemical basis for T1rho relaxation in cartilage at clinical field strengths and typical clinical spin lock frequencies are not fully understood due to differences in relaxation processes between higher and lower fields and spin lock frequencies. 35,36 Studies consistently show the sensitivity of compositional MRI to potentially reversible cartilage matrix changes. Several studies have shown reductions in T2 and T1rho values after running, a repetitive load-bearing activity [37][38][39] demonstrating the sensitivity of these metrics to transient changes in cartilage water content and collagen orientation.…”

Section: Compositional Mri Allows For Noninvasive Early Assessment Of Articular Cartilage Statusmentioning

confidence: 96%

“…T1rho measures a combination of T1 (spin‐lattice) and T2 (spin‐spin) relaxations 34 . While T1rho is sensitive to both T1 and T2 tissue properties, the biochemical basis for T1rho relaxation in cartilage at clinical field strengths and typical clinical spin lock frequencies are not fully understood due to differences in relaxation processes between higher and lower fields and spin lock frequencies 35,36 …”

Section: Compositional Mri Allows For Noninvasive Early Assessment Of Articular Cartilage Statusmentioning

confidence: 99%

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Can we afford to ignore the biology of joint healing and graft incorporation after ACL reconstruction?

Chu

2021

Journal Orthopaedic Research

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Anterior cruciate ligament (ACL) reconstruction is successful at restoring stability to return ACL injured patients to high‐demand work, sports, and recreational activities. The development of posttraumatic osteoarthritis (OA) in roughly half of patients just 10–15 years after ACLR highlight the need to improve clinical care pathways. Graft failure and reinjury rates, which further increase OA risk, also remain high for younger and more active patients. The biological components of joint recovery and graft incorporation, therefore, impact short‐ and long‐term clinical outcomes. Biochemical and magnetic resonance imaging (MRI) data show substantial compromise of articular cartilage metabolism and matrix composition after ACL injury and reconstructive surgery suggesting a potential need for activity modulation in early recovery. Furthermore, joint recovery is variable with compositional MRI studies showing progressive cartilage degeneration 1 and 2 years after ACLR. Biopsy and MRI studies also show high variability in ACL graft characteristics within the 1st year after ACLR followed by continued graft maturation into the 2nd year and beyond. To improve the care of ACL injured patients, there is a critical need for clinical attention and scientific inquiry into timing the reintroduction of higher load activities in relationship to neuromuscular recovery, joint biology, and graft maturation. In addition to symptomatic and mechanical recovery, development and validation of biological markers for joint and cartilage homeostasis as well as ACL graft healing are needed for personalized decision making on rehabilitation needs, reduction of OA risk, and resumption of athletic, recreational, and vocational activities.

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Section: Compositional Mri Allows For Noninvasive Early Assessment Of Articular Cartilage Statusmentioning

confidence: 96%

Section: Compositional Mri Allows For Noninvasive Early Assessment Of Articular Cartilage Statusmentioning

confidence: 99%

Can we afford to ignore the biology of joint healing and graft incorporation after ACL reconstruction?

Chu

2021

Journal Orthopaedic Research

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“…Previous work both at this and other institutions has demonstrated the capacity of MRI to noninvasively identify morphometric and compositional features of traumatic injury and possible markers of progressive disease. [102,109] That previous work has also demonstrated the extensibility of imaging-derived measures from a research setting into a clinical setting. [109] However, that previous work has not fully explored the use of MRI diagnostic techniques to evaluate the entire history of disease from traumatic onset through PTOA progression to establish efficacy in a translatable preclinical model.…”

Section: Resultsmentioning

confidence: 96%

“…[102,109] That previous work has also demonstrated the extensibility of imaging-derived measures from a research setting into a clinical setting. [109] However, that previous work has not fully explored the use of MRI diagnostic techniques to evaluate the entire history of disease from traumatic onset through PTOA progression to establish efficacy in a translatable preclinical model. The purpose of the present work was to model acute cartilage injury, and correlate imaging findings to end-stage osteoarthritic changes.…”

Section: Resultsmentioning

confidence: 96%

Multimodal evaluation of local and whole-joint cartilage changes in an in vivo animal model

Heckelsmiller¹

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Osteoarthritis is a chronic, deleterious disease of the joints. It currently affects nearly 25 million Americans. Clinically, osteoarthritis presents as joint pain and verified by radiographic evidence of joint space narrowing. Unfortunately, symptomatic osteoarthritis describes the later stages of disease, at which point irreversible cartilage and bone damage has occurred. Crosssectional imaging modalities offer the promise of visualizing early features of disease, enabling the development and evaluation of interventions to forestall or prevent degenerative change. Modalities of clinical interest include magnetic resonance imaging (MRI) and multi-detector computed tomography (MDCT). The following work describes the efficacy of MRI-derived measures for the identification and accurate quantification of local and whole joint changes in articular cartilage thickness changes in vivo. This was performed as part of a study investigating the diagnostic potential of clinical morphometric and compositional MRI to identify early features of osteoarthritis in a large animal model of traumatic knee joint injury. Surgically induced trauma consisted of a partial medial meniscectomy and blunt impact of either 0 J, 0.6 J, or 1.2 J to the weight-bearing cartilage of the medial femur. The study was six months in duration. To evaluate the accuracy of MRI-derived measures of cartilage thickness, imaging acquired at time of euthanasia was compared to high-resolution contrast-enhanced micro-computed tomography (micro CT). 3dimensional multimodal analysis demonstrated that morphometric MRI imaging is sensitive to sub-voxel changes in cartilage thickness. Therefore, MRI is a clinically relevant modality to quantify subtle cartilage damage, thereby presenting an opportunity to identify patients earlier in the disease process. vi

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Characterizing cartilage-specific T1rho MRI for clinical translation and application

Abstract: showing concentric-ringed, carrageenan-agarose phantom used in this work. The midline 20 ms T1rho images for the 1.5T and 3.0T scans are shown at right.

Cited by 2 publications

References 62 publications

Can we afford to ignore the biology of joint healing and graft incorporation after ACL reconstruction?

Can we afford to ignore the biology of joint healing and graft incorporation after ACL reconstruction?

Multimodal evaluation of local and whole-joint cartilage changes in an in vivo animal model

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