2017
DOI: 10.3168/jds.2017-13229
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Characterizing effects of feed restriction and glucagon-like peptide 2 administration on biomarkers of inflammation and intestinal morphology

Abstract: Inadequate feed consumption reduces intestinal barrier function in both ruminants and monogastrics. Objectives were to characterize how progressive feed restriction (FR) affects inflammation, metabolism, and intestinal morphology, and to investigate if glucagon-like peptide 2 (GLP2) administration influences the aforementioned responses. Twenty-eight Holstein cows (157 ± 9 d in milk) were enrolled in 2 experimental periods. Period 1 [5 d of ad libitum (AL) feed intake] served as baseline for period 2 (5 d), du… Show more

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Cited by 75 publications
(67 citation statements)
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“…Cows in the current experiment were restricted to 31% of their requirement for maintenance and pregnancy and therefore may have been experiencing some intestinal atrophy with damage to enterocyte structure. Indeed, plasma concentration of haptoglobin was greater during feed restriction compared with the AL period, which agrees with haptoglobin results from feed restriction of lactating dairy cows (Kvidera et al, 2017). A shortage of PC could possibly result in a decreased generation of new enterocytes because PC is a key component of the lipid bilayer of cell membranes.…”
Section: Fat Loadingsupporting
confidence: 84%
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“…Cows in the current experiment were restricted to 31% of their requirement for maintenance and pregnancy and therefore may have been experiencing some intestinal atrophy with damage to enterocyte structure. Indeed, plasma concentration of haptoglobin was greater during feed restriction compared with the AL period, which agrees with haptoglobin results from feed restriction of lactating dairy cows (Kvidera et al, 2017). A shortage of PC could possibly result in a decreased generation of new enterocytes because PC is a key component of the lipid bilayer of cell membranes.…”
Section: Fat Loadingsupporting
confidence: 84%
“…Choline supplementation may improve fat absorption by helping repair a damaged protective barrier in the small intestine caused by feed restriction, choline deficiency, or both. Based on biomarkers, the protective barrier of the small intestine in lactating dairy cows appeared to deteriorate in a linear fashion as feed intake decreased from 100% to 80, 60, and 40% of AL amounts over a 5-d period (Kvidera et al, 2017). Feed restriction by about 65% resulted in decreased expression of genes related to preservation of barrier function and immunity in the jejunum of Holstein steers (Wood et al, 2016).…”
Section: Fat Loadingmentioning
confidence: 99%
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“…While prior data have focused on the effect of lipids regulating intake, in cases of low feed intake, such as weaned pigs, the effect of lipids on gastrointestinal peptide secretion and the impact on intestinal barrier function and potential for immune modulation may be as relevant as the impact on intake. Treatment with GLP-2 decreases serum amyloid A and haptoglobin concentrations in the blood providing evidence that it can reduce inflammation in conditions of low intake (Kvidera et al, 2017). Like GLP-2, there is also evidence of anti-inflammatory effects of GLP-1 for a number of chronic conditions in humans (Lee and Jun, 2016).…”
Section: Lipid Nutritionmentioning
confidence: 99%
“…To further evaluate this, future experiments should test the effect of GLP hormones in premature RE and under challenge conditions. The latter acknowledges that both GLP-1 and GLP-2 display their beneficial effects on intestinal epithelia most prominently under stress conditions like inflammation (Insuela & Carvalho, 2017;Nakame, Kaji, Mukai, Shinyama, & Matsufuji, 2016) and feed restriction (Kvidera et al, 2017;Sigalet et al, 2014).…”
Section: Discussionmentioning
confidence: 99%