Background: Studies of low-energy fusion of light nuclei are important in astrophysical modeling, with small variations in reaction rates having a large impact on nucleosynthesis yields. Due to the lack of experimental data at astrophysical energies, extrapolation and microscopic methods are needed to model fusion probabilities. Purpose: To investigate deep sub-barrier 12 C+ 12 C fusion cross sections and establish trends for the S factor. Method: Microscopic methods based on static Hartree-Fock and time-dependent Hartree-Fock (TDHF) meanfield theory are used to obtain 12 C+ 12 C ion-ion fusion potentials. Fusion cross sections and astrophysical S factors are then calculated using the incoming wave boundary condition method. Results: Both density-constrained frozen Hartree-Fock (DCFHF) and density-constrained TDHF (DC-TDHF) predict a rising S factor at low energies, with DC-TDHF predicting a slight damping in the deep sub-barrier region (≈1 MeV). Comparison between DC-TDHF calculations and maximum experimental cross sections in the resonance peaks are good. However, the discrepancy in experimental low-energy results inhibits interpretation of the trend. Conclusions: Using the fully microscopic DCFHF and DC-TDHF methods, no S factor maximum is observed in the 12 C+ 12 C fusion reaction. In addition, no extreme sub-barrier hindrance is predicted at low energies. The development of a microscopic theory of fusion including resonance effects, as well as further experiments at lower energies must be done before the deep sub-barrier behavior of the reaction can be established.