Characterizing the contribution of inflammasome-derived exosomes in the activation of the immune response

Abal, Miguel

doi:10.21037/atm.2017.03.48

Cited by 8 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the nervous system, EVs participate in neuron-glial crosstalk, a bidirectional communication important to preserve brain homeostasis and, when dysfunctional, involved in several CNS diseases. The impact of this type of intercellular communication and its relevance at the clinical level is being strongly recognized by the scientific community [ 165 ].…”

Section: Cell Death By Nlrp3 Inflammasome-mediated Pyroptosismentioning

confidence: 99%

NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer’s Disease

Zeller

Dias

Sebastião

et al. 2021

JAD

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease commonly diagnosed among the elderly population. AD is characterized by the loss of synaptic connections, neuronal death, and progressive cognitive impairment, attributed to the extracellular accumulation of senile plaques, composed by insoluble aggregates of amyloid-β (Aβ) peptides, and to the intraneuronal formation of neurofibrillary tangles shaped by hyperphosphorylated filaments of the microtubule-associated protein tau. However, evidence showed that chronic inflammatory responses, with long-lasting exacerbated release of proinflammatory cytokines by reactive glial cells, contribute to the pathophysiology of the disease. NLRP3 inflammasome (NLRP3), a cytosolic multiprotein complex sensor of a wide range of stimuli, was implicated in multiple neurological diseases, including AD. Herein, we review the most recent findings regarding the involvement of NLRP3 in the pathogenesis of AD. We address the mechanisms of NLRP3 priming and activation in glial cells by Aβ species and the potential role of neurofibrillary tangles and extracellular vesicles in disease progression. Neuronal death by NLRP3-mediated pyroptosis, driven by the interneuronal tau propagation, is also discussed. We present considerable evidence to claim that NLRP3 inhibition, is undoubtfully a potential therapeutic strategy for AD.

show abstract

Section: Cell Death By Nlrp3 Inflammasome-mediated Pyroptosismentioning

confidence: 99%

NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer’s Disease

Zeller

Dias

Sebastião

et al. 2021

JAD

View full text Add to dashboard Cite

show abstract

“…"ASC specks" 25 , as well as the NLRP3 protein itself 40 , have been observed in the extracellular space and can propagate inflammation in a paracrine manner 41 . The term "inflammasome-derived exosomes" 42 was coined based on this realization that inflammasome activity results in the release of a pro-inflammatory class of extracellular vesicles (EVs) containing typically cytosolic proteins into the extracellular space. Our current understanding of inflammasomes in PD suggests that pyroptosis may be ongoing in response to a variety of sterile triggers associated with metabolic stress, proteinopathy, and cell death.…”

Section: Introductionmentioning

confidence: 99%

Plasma-borne indicators of inflammasome activity in Parkinson’s disease patients

Anderson

Herrmann

Andrew

et al. 2021

npj Parkinsons Dis.

View full text Add to dashboard Cite

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms and loss of dopaminergic neurons of the substantia nigra. Inflammation and cell death are recognized aspects of PD suggesting that strategies to monitor and modify these processes may improve the management of the disease. Inflammasomes are pro-inflammatory intracellular pattern recognition complexes that couple these processes. The NLRP3 inflammasome responds to sterile triggers to initiate pro-inflammatory processes characterized by maturation of inflammatory cytokines, cytoplasmic membrane pore formation, vesicular shedding, and if unresolved, pyroptotic cell death. Histologic analysis of tissues from PD patients and individuals with nigral cell loss but no diagnosis of PD identified elevated expression of inflammasome-related proteins and activation-related “speck” formation in degenerating mesencephalic tissues compared with controls. Based on previous reports of circulating inflammasome proteins in patients suffering from heritable syndromes caused by hyper-activation of the NLRP3 inflammasome, we evaluated PD patient plasma for evidence of inflammasome activity. Multiple circulating inflammasome proteins were detected almost exclusively in extracellular vesicles indicative of ongoing inflammasome activation and pyroptosis. Analysis of plasma obtained from a multi-center cohort identified elevated plasma-borne NLRP3 associated with PD status. Our findings are consistent with others indicating inflammasome activity in neurodegenerative disorders. Findings suggest mesencephalic inflammasome protein expression as a histopathologic marker of early-stage nigral degeneration and suggest plasma-borne inflammasome-related proteins as a potentially useful class of biomarkers for patient stratification and the detection and monitoring of inflammation in PD.

show abstract

“…They depend on enzymes (16) and cytokines (17) that participate in inflammatory process of male genitalia (14) . Group of researchers highlighted the importance of inflammasome protein NLRP3 as a "physiological low level of inflammation" for fertility (6).It had been suggested that low level of NLRP3 is essential for Sertoli cell production of low levels of IL1B to maintain IL1 alpha (18) but higher rate of inflammasome expression will results in higher level of inflammasome activation cytokines such as IL-1B and IL-18 (19) and served as a proinflammatory signals generating an inflammatory process in the testis such as leucocyte infiltration and cell death signaling and caspase 1 activation (20)(21)(22) .Also, it might activate ASC adaptor protein in both sperm cell and leucocytes in semen resulting in inflammatory cell death (23) . To date, the primary focus of inflammasome research has been anchored by NLRP3, which is a cytoplasmic protein that is primarily expressed in monocytes, macrophages, granulocytes, dendritic cells, epithelial cells and osteoblasts (24).…”

Section: Discussionmentioning

confidence: 99%

Association of Seminal Plasma Level of NLRP3 Inflammasome Protein with Quality of Seminal Fluid Parameters Among Infertile Men

Younis¹,

Ghazi²,

Al-Kawaz³

et al. 2018

IJEIR

View full text Add to dashboard Cite

Background:inflammasome protein govern the inflammatory process. The elevation of NLRP3 inflammasome might be related to bad seminal fluid analysis results. Objectives:This study aimed to evaluate seminal plasma NLRP3 protein and its relation with seminal fluid analysis parameters before and after in vitro sperm activation. Patients and Methods: a total of 50 infertile patients were collected form higher institute of infertility diagnosis and assisted reproductive technique, there semen samples were processed for seminal fluid analysis before and after in vitro sperm activation. NLRP3 inflammasome protein were measured in seminal plasma. Results:the mean level of NLRP3 protein was 5.12 ng/ml. the higher level of NLRP3 protein (4.5ng/ml) associated with lower sperm concentration, grade A, B, C and higher level of grade D motility. However, 50% of those patients have an improvement in their seminal fluid analysis after in vitro sperm activation. Conclusion:Elevation of NLRP3 protein in seminal plasma may be associated with the increased leukocytospermia, bad sperm quality and unresponsiveness to in vitro sperm activation among infertile male.

show abstract

Characterizing the contribution of inflammasome-derived exosomes in the activation of the immune response

Cited by 8 publications

References 12 publications

NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer’s Disease

NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer’s Disease

Plasma-borne indicators of inflammasome activity in Parkinson’s disease patients

Association of Seminal Plasma Level of NLRP3 Inflammasome Protein with Quality of Seminal Fluid Parameters Among Infertile Men

Contact Info

Product

Resources

About