Characterizing the Effect of Anti-Vascular Endothelial Growth Factor Therapy on Treatment-Naive Choroidal Neovascularization Using Optical Coherence Tomography Angiography

Muakkassa, Nora W.; Chin, Adam T; Carlo, Talisa E de; Klein, Kendra; Baumal, Caroline R.; Witkin, André J.; Duker, Jay S.; Waheed, Nadia K.

doi:10.1097/iae.0000000000000836

Cited by 118 publications

(86 citation statements)

References 22 publications

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“…Researchers also demonstrated the usefulness of OCTA in evaluating the response to anti-VEGF treatment [98,99] . OCTA has been demonstrated to be useful to identify the retinal vascular pathology in diseases such as macular telangiectasia Type 2 [100] , sickle cell retinopathy [101] , central serous chorioretinopathy (CSCR) [102] , and glaucoma [103] .…”

Section: For Retinal Vein Occlusions(rvo) Kashani Et Al Reported Finmentioning

confidence: 99%

New Frontiers in Retinal Imaging

Liu

Paulus

2016

International Journal of Ophthalmic Research

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Ophthalmology is one of the most technology-driven medical specialties with numerous recent advances due to improvements in imaging technology. Advances in retinal imaging have allowed for better understanding of the eye in health and disease, retinal pathophysiology, documenting of disease progression,and assessing therapeutic response. During the last 50 years, both the hardware such as lasers in addition to software image analysis have significantly evolved. These improvements have included facilitating the progress of the ocular examination, reducing the discomfort of patients, and obtaining high quality non-invasive images. This article will review the classic retinal imaging modalities, state-of-the-art retinal imaging technologies, and an introduction of emerging imaging technologies.

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Section: For Retinal Vein Occlusions(rvo) Kashani Et Al Reported Finmentioning

confidence: 99%

New Frontiers in Retinal Imaging

Liu

Paulus

2016

International Journal of Ophthalmic Research

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“…26 OCTA can be used to monitor CNV after anti-vascular endothelial growth factor (anti-VEGF) treatment with reduced CNV density and size, vascular rarefication, and loss of smaller or peripheral capillaries after therapy. [27][28][29][30][31] Flow within a vascular network may be apparent on OCTA in a disciform scar from AMD. 32 One study demonstrated alterations in the retinal vasculature in early to intermediate AMD with reduced vessel density in both the superficial and deep inner retinal plexuses and reduced choroidal thickness compared with control.…”

Section: Age-related Macular Degeneration and Choroidal Neovascularizmentioning

confidence: 99%

Advances in Optical Coherence Tomography Angiography

Baumal¹,

Carlo²

2016

US Ophthalmic Review

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Optical coherence tomography angiography (OCTA) is an exciting new imaging technology that allows for non-invasive non-dye-based visualization of blood flow in the posterior pole. The technology has been used to image a variety of chorioretinal disorders including choroidal neovascularization in age-related macular degeneration, diabetic retinopathy, retinal arterial occlusion, retinal vein occlusion, and macular telangiectasia type 2. Continued advances in the software will improve the quality of OCTA and reduce image artifacts.

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“…Az AMD és az AMD-re adott kezelés hatására a CNV szerkezetében történő rövid távú válto-zások nemrégiben kerültek rendszerszerű leírásra [12].…”

Section: Eredeti Közleményunclassified

“…Muakkassa és Lumbroso tanulmányai a különböző tí-pusú CNV méretváltozásait követik nyomon [12,22]. Muakkassa azt tapasztalta, hogy a CNV legnagyobb lineáris kiterjedése (greatest linear dimension -GLD) 23,6%-os, míg a CNV összterülete 29,8%-os csökkenést mutatott 3 hónapos VEGF-gátló kezelés kapcsán.…”

Section: Eredeti Közleményunclassified

Szemfenéki érfestés festék nélkül: Az optikai koherencia tomográfia alapú angiográfia exsudativ típusú időskori maculadegenerációban

et al. 2016

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Bevezetés: Az időskori maculadegeneráció exsudativ formájának elfogadott és hatékony kezelése a vascularis endothelialis növekedési faktort gátló kezelés. Célkitűzés: Annak morfológiai leírása, milyen érrendszer észlelhető a macula területében több éve tartó tartós kezelés után. Módszer: A vizsgálatba 48 beteget (34 nő, 14 férfi, életkor 74,4 ± 8,0 év) vontak be, akiknél legalább 24 hónappal korábban kezdték meg a vascularis endothelialis növekedési faktort gát-ló kezelést (ranibizumab, aflibercept). A kezelt 56 szemnél a követési idő (53,8 ± 31,0 hónap) alatt összesen 7,6 ± 4,9 injekciót alkalmaztak. AngioVue (Optovue Inc., Fremont, CA, Amerikai Egyesült Államok) készülékkel optikai koherencia tomográfia-angiográfia vizsgálatot végeztek. Eredmények: A felszínes retinaerek károsodását 5/56 esetben, a mélyebb retinakeringés kiesését 9/56 esetben tapasztalták. A choriocapillaris károsodására, az érújdonképződést követő eltérésekre négyféle kép volt a jellemző: 1. pigmenthám-és choriocapillaris-atrophia, 2. submacularis heg, 3. aktív neovascularisatio, 4. intraretinalis ciszták. Következtetés: Az optikai koherencia tomográfia-angiográfia noninvazív módszer, amelynek segítségével a maculadegeneráció jól nyomon követhető. Orv. Hetil., 2016, 157(42), 1683-1690. Kulcsszavak: maculadegeneráció, optikai koherencia tomográfia, angiográfia Angiography of the ocular fundus without dye: Optical coherence tomography based angiography in exsudative age-related macular degenerationIntroduction: Vascular endothelial growth factor antibody therapy is an established treatment of exsudative age-related macular degeneration. Aim: The morphologic characterisation of the macular microvasculature after longstanding treatment. Method: Forty-eight patients (34 women and 14 men; age, 74.4 ± 8.0 years) were enrolled in the study. During follow-up time (53.8 ± 31.0 months), 7.6 ± 4.9 injections were administered in 56 eyes. Optical coherence tomography angiographic examination was performed with AngioVue (Optovue Inc. Fremont, CA, USA). Results: Distortion of the superficial retinal plexus and foveal avascular zone enlargement were noted in 5/56 eyes, deep retinal plexus defect was detected in 9/56 cases. Destruction of the choriocapillaries and the former neovascularisation could be found in 4 different patterns: 1. pigment epithelium and choriocapillary atrophy, 2. submacular scar, 3. active leaking choroidal neovascularisation, 4. intraretinal cysts. Conclusion: Optical coherence tomography angiography is a novel non-invasive method, which enables the follow up of macular degeneration.

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Characterizing the Effect of Anti-Vascular Endothelial Growth Factor Therapy on Treatment-Naive Choroidal Neovascularization Using Optical Coherence Tomography Angiography

Abstract: Both CNV greatest linear dimension and area measured using OCTA decreased after anti-VEGF treatment in most patients. Optical coherence tomography angiography may be a useful tool for monitoring and quantifying the response of CNV to treatment.

Cited by 118 publications

References 22 publications

New Frontiers in Retinal Imaging

New Frontiers in Retinal Imaging

Advances in Optical Coherence Tomography Angiography

Szemfenéki érfestés festék nélkül: Az optikai koherencia tomográfia alapú angiográfia exsudativ típusú időskori maculadegenerációban

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