Characterizing the performance of the hydrodynamic trap using a control-based approach

Shenoy, Anish; Tanyeri, Melikhan; Schroeder, Charles M.

doi:10.1007/s10404-014-1495-7

Cited by 28 publications

(23 citation statements)

References 37 publications

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“…By incorporating multiple on-chip valves, it was shown that single particles can be precisely manipulated in two dimensions using the sole action of fluid flow (11). In all cases, the automated hydrodynamic trap relies on a simple proportionalintegral-derivative (PID) controller for particle manipulation (10,20), which was sufficient for precise confinement of small particles in solution (e.g., 500-nm particles confined to within 180 nm of a set point position) (11). Despite these advances, however, the original automated hydrodynamic trap is strictly limited to trapping and manipulation of single particles.…”

mentioning

confidence: 99%

Stokes trap for multiplexed particle manipulation and assembly using fluidics

Shenoy

Rao

Schroeder

2016

Proc. Natl. Acad. Sci. U.S.A.

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123

134

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The ability to confine and manipulate single particles and molecules has revolutionized several fields of science. Hydrodynamic trapping offers an attractive method for particle manipulation in free solution without the need for optical, electric, acoustic, or magnetic fields. Here, we develop and demonstrate the Stokes trap, which is a new method for trapping multiple particles using only fluid flow. We demonstrate simultaneous manipulation of two particles in a simple microfluidic device using model predictive control. We further show that this approach can be used for fluidic-directed assembly of multiple particles in solution. Overall, this technique opens new vistas for fundamental studies of particle-particle interactions and provides a new method for the directed assembly of colloidal particles.microfluidics | trapping | directed assembly | Stokes | hydrodynamic

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mentioning

confidence: 99%

Stokes trap for multiplexed particle manipulation and assembly using fluidics

Shenoy

Rao

Schroeder

2016

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

123

134

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“…173 The application of this control system was only on the extensional direction, since the ow in the compressional direction is intrinsically stable. 174 The feedback control algorithm adjusted a valve constriction based on a linear equation relating the particle's hydrodynamic forces to its distance from the stagnation point. 175 To fully automate the system, calibration of the trap's response as a function of ow control valve characteristics and channel dimensions were also performed.…”

Section: Trapping and Manipulationmentioning

confidence: 99%

Stagnation point flows in analytical chemistry and life sciences

Brimmo

Qasaimeh

2017

RSC Adv.

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“…In recent decades, methods of spatial particle manipulation by electric field have been used to capture, focus and define micro‐ and nanoparticles along with optical , mechanical , and magnetic methods. Target cells can be moved by electric field without strong damage.…”

Section: Introductionmentioning

confidence: 99%

Barrier contactless dielectrophoresis: A new approach to particle separation

Podoynitsyn

Sorokina

Klimov

et al. 2019

Separation Science Plus

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Barrier contactless dielectrophoresis is proposed as a method for microbiological particle separation. Design of a separation device for barrier contactless dielectrophoresis is discussed. The principle of separation device is based on formation of barriers of gradient fields in the volume of separation chamber by electrodes with passivation dielectric coating of silicon carbide. A feature of the method is absence of contact between separated samples and conductive elements of electrode structure. The proposed method is highly efficient and easy to use in comparison with dielectrophoresis on isolated structures and conventional planar systems. Computer simulation of electric field distribution over dielectrophoretic barriers is carried out, and effect of the thickness of the passivation coating on dielectrophoretic properties of barriers is shown. Forces acting on a particle (a yeast cell with a diameter of 7 μm) in separation chamber are evaluated using computer simulation data. Ability of the cell to be captured by the method of contactless barrier dielectrophoresis is theoretically predicted and confirmed experimentally, using yeast cells. The yeast cells subjected to positive dielectrophoresis can be effectively captured (up to 90%) by the separation device at the applied voltage of 20 V and 100 kHz and at flow rate of 20 mL/h.

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Characterizing the performance of the hydrodynamic trap using a control-based approach

Cited by 28 publications

References 37 publications

Stokes trap for multiplexed particle manipulation and assembly using fluidics

Stokes trap for multiplexed particle manipulation and assembly using fluidics

Stagnation point flows in analytical chemistry and life sciences

Barrier contactless dielectrophoresis: A new approach to particle separation

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