Characterizing the Somatosensory Profile of Patients With Failed Back Surgery Syndrome With Unilateral Lumbar Radiculopathy Undergoing Spinal Cord Stimulation: A Single Center Prospective Pilot Study

Ramaswamy, Shankar; Wodehouse, Theresa; Langford, R. M.; Thomson, Simon; Taylor, Rod S; Mehta, Vivek

doi:10.1111/ner.12862

Cited by 9 publications

(7 citation statements)

References 67 publications

(79 reference statements)

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“…In the literature (Campbell et al., 2015; R.R. Edwards et al., 2016; Ramaswamy et al., 2019; Yarnitsky et al., 2012), the predictive results of treatment of response over time by CPM appear to be influenced by the intervention type. Patients with efficient CPM response reported greater improvements by peripheral interventions targeting nociception.…”

Section: Discussionmentioning

confidence: 99%

“…Edwards et al., 2016). However, chronic pain patients with low‐efficient CPM reported better responses to centrally acting treatments, such as duloxetine (Yarnitsky et al., 2012), spinal cord stimulation (Ramaswamy et al., 2019), and tDCS (Tavares et al., 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, CPM has shown a potential role as a surrogate of treatment response in chronic pain patients in previous studies. Several studies reported that an improvement in CPM paradigm is correlated with parallel pain improvement, after pharmacological (ketamine and pregabalin) (Niesters et al., 2013; Wodehouse et al., 2018), behavioral (placebo) (Niesters et al., 2013), and neuromodulatory interventions (e.g., spinal cord stimulation) (Ramaswamy et al., 2019) and non‐invasive brain stimulation (Flood et al., 2016). These results underscore the potential use of CPM as a chronic pain biomarker during longitudinal assessments.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies reported that an improvement in CPM paradigm is correlated with parallel pain improvement, after pharmacological (ketamine and pregabalin) (Niesters et al, 2013;Wodehouse et al, 2018), behavioral (placebo) (Niesters et al, 2013), and neuromodulatory interventions (e.g., spinal cord stimulation) (Ramaswamy et al, 2019) and non-invasive brain stimulation (Flood et al, 2016).…”

Section: Cpm As a Predictive Marker For Painmentioning

confidence: 99%

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Cross‐sectional and longitudinal analysis of conditioned pain modulation and pain in fibromyalgia: CPM as an effect modifier of pain changes over time

Castelo‐Branco,

Pacheco‐Barrios,

Cardenas‐Rojas

et al. 2024

Physiotherapy Res Intl

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Background and PurposeFibromyalgia (FM) is associated with altered descending pain modulatory pathways, which can be assessed through Conditioned Pain Modulation (CPM). In this study, we aimed to explore the relationship between CPM and self‐reported baseline characteristics in patients with fibromyalgia. We also performed a longitudinal analysis exploring CPM as a potential predictor of clinical improvement over time in individuals with FM.MethodsWe performed cross‐sectional univariable and multivariable analyses of the relationship between CPM and other variables in 41 FM patients. We then performed longitudinal analyses, building linear mixed‐effects models with pain in the Visual Analogue Scale (VAS) as the dependent variable, and testing for the interaction between time and CPM. We also tested the interaction between CPM and time in models using other outcomes, such as the revised Fibromyalgia Impact Questionnaire and Quality of Life Scale (QOLs).ResultsWe found no association between CPM and other demographic and clinical variables in the univariable analysis. We found a statistically significant association in the multivariable linear regression model between CPM and the QOLs at the baseline after controlling for age, sex, and duration of symptoms. In the longitudinal analyses, we found that CPM is an effect modifier for clinical improvement over time for the pain VAS, QOLs, and FIQR: individuals with low‐efficient CPM at the baseline have a different (improved) pattern of response over time when compared to those with high‐efficient CPM.ConclusionsOur findings suggest that CPM is not a reliable biomarker of clinical manifestations in chronic pain patients during cross‐sectional assessments. However, our results are consistent with previous findings that CPM can be used to predict the evolution of clinical pain over time. We expect that our findings will help in the selection of patients with the best profile to respond to specific interventions and assist clinicians in tailoring pain treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Cpm As a Predictive Marker For Painmentioning

confidence: 99%

See 2 more Smart Citations

Cross‐sectional and longitudinal analysis of conditioned pain modulation and pain in fibromyalgia: CPM as an effect modifier of pain changes over time

Castelo‐Branco,

Pacheco‐Barrios,

Cardenas‐Rojas

et al. 2024

Physiotherapy Res Intl

View full text Add to dashboard Cite

show abstract

“…Ramaswamy et al 56 have studied the role of CPM in patients with FBSS before and after three months of receiving SCS. At baseline, 65% of the patients with FBSS had inefficient CPM; remarkably, after three months of SCS therapy, they turned into responders with efficient CPM.…”

Section: Conditioned Pain Modulationmentioning

confidence: 99%

Allodynia, Hyperalgesia, (Quantitative) Sensory Testing and Conditioned Pain Modulation in Patients With Complex Regional Pain Syndrome Before and After Spinal Cord Stimulation Therapy

Kriek

Vos²,

Groeneweg³

et al. 2023

Neuromodulation: Technology at the Neural Interface

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Postoperative early initiation of sequential exercise program in preventing persistent spinal pain syndrome type-2 after modified transforaminal lumbar interbody fusion: a prospective randomized controlled trial

Nie,

Chen,

Huang

et al. 2024

Eur Spine J

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Characterizing the Somatosensory Profile of Patients With Failed Back Surgery Syndrome With Unilateral Lumbar Radiculopathy Undergoing Spinal Cord Stimulation: A Single Center Prospective Pilot Study

Cited by 9 publications

References 67 publications

Cross‐sectional and longitudinal analysis of conditioned pain modulation and pain in fibromyalgia: CPM as an effect modifier of pain changes over time

Cross‐sectional and longitudinal analysis of conditioned pain modulation and pain in fibromyalgia: CPM as an effect modifier of pain changes over time

Allodynia, Hyperalgesia, (Quantitative) Sensory Testing and Conditioned Pain Modulation in Patients With Complex Regional Pain Syndrome Before and After Spinal Cord Stimulation Therapy

Postoperative early initiation of sequential exercise program in preventing persistent spinal pain syndrome type-2 after modified transforaminal lumbar interbody fusion: a prospective randomized controlled trial

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