Characterizing the Temperature Dependent Spring-Back Behavior of Poly(Methyl Methacrylate) (PMMA) for Hot Embossing

Mathiesen, Danielle; Dupaix, Rebecca B.

doi:10.1007/978-3-319-06980-7_9

Cited by 2 publications

(3 citation statements)

References 29 publications

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“…Spring‐back in hot embossing has been observed and constitutive modeling of material properties near T g undertaken to characterize it in Ref. . There remains the question of why this phenomenon is seen only at locations b2, b3, and b4.…”

Section: Micro‐channel Replication Resultsmentioning

confidence: 99%

Replication of surface micro‐features using variothermal injection molding: Application to micro‐fluidics

Pittman¹,

Wlodarski²

2017

Polymer Engineering & Sci

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We study injection molding of mesoscale items with µm‐scale surface features, namely micro‐fluidic channels, relating replication quality to process conditions. Using variothermal molding, the variables are the pre‐heat temperature of the cavity insert surface before melt injection and the mold cooling start time. Surface temperatures and in‐cavity melt pressures are continuously measured. Rounded upper corners of the micro‐channels are used as an index of replication quality. For polymethylmethacrylate the thickness of a layer with solid‐like properties (below 124°C) is calculated and used with pressures to interpret results. It is shown how improved replication correlates with low layer thickness at the end of the compression phase when pressures are at a maximum, and the necessity of properly timed cooling to lock in replication before melt pressures fall. Results show how the inter‐relationship of layer thickness and melt pressure is controlled by pre‐heat temperature and cooling switch‐on time. Delayed cooling can result in poorer replication, due to a retraction effect of the plastic. Too early cooling also reduces replication of parallel‐to‐flow features downstream of transverse features, and of the replication of transverse features on their downstream side. Good replication of 100 and 70 µm channels requires lower pre‐heat than 400 µm ones. POLYM. ENG. SCI., 58:1726–1738, 2018. © 2017 Society of Plastics Engineers

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Section: Micro‐channel Replication Resultsmentioning

confidence: 99%

Replication of surface micro‐features using variothermal injection molding: Application to micro‐fluidics

Pittman¹,

Wlodarski²

2017

Polymer Engineering & Sci

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“…Vacuum bagging completely eliminates time constrains resulting from using solvents, adhesives, or surface treatments. With fabrication technologies including hot embossing or imprinting, 75, 76 laser ablation, 77 injection molding 78 and soft lithography, dimensions of plastic microchannels can be achieved in the range of 15–30 μm. Recently, simple methods have been developed for rapid prototyping of thermoplastic microfluidic platforms.…”

Section: Microfluidic Platforms For Biomarker Detectionmentioning

confidence: 99%

“…The hot embossing 75, 76 or imprinting is an established method to fabricate microchannels in common polymer such as polystyrene (PS), polyethylene terephthalate glycol (PETG), PMMA, PVC, and polycarbonate. Silicon stamps are the more commonly used embossing tools for the fabrication of these polymeric microfluidic devices.…”

Section: Microfluidic Platforms For Biomarker Detectionmentioning

confidence: 99%

Biomarker detection for disease diagnosis using cost-effective microfluidic platforms

Sanjay

Dou

et al. 2015

Analyst

236

171

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Early and timely detection of disease biomarkers can prevent the spread of infectious diseases, and drastically decrease the death rate of people suffering from different diseases such as cancer and infectious diseases. Because conventional diagnostic methods have limited application in low-resource settings due to the use of bulky and expensive instrumentation, simple and low-cost point-of-care diagnostic devices for timely and early biomarker diagnosis, is the need of the hour, especially in rural areas and developing nations. The microfluidics technology possesses remarkable features for simple, low-cost, and rapid disease diagnosis. There have been significant advances in the development of microfluidic platforms for diseases biomarker detection. This article reviews recent advances in biomarker detection using cost-effective microfluidic devices for disease diagnosis, with the emphasis on infectious disease and cancer diagnosis in low-resource settings. This review first introduces different microfluidic platforms (e.g. polymer and paper-based microfluidics) used for disease diagnosis, with a brief description of their common fabrication techniques. Then, it highlights various detection strategies for disease biomarker detection using microfluidic platforms, including colorimetric, fluorescence, chemiluminescence, electrochemiluminescence (ECL), and electrochemical detection. Finally, it discusses the current limitations of microfluidics devices for disease biomarker detection and the future perspectives.

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Characterizing the Temperature Dependent Spring-Back Behavior of Poly(Methyl Methacrylate) (PMMA) for Hot Embossing

Cited by 2 publications

References 29 publications

Replication of surface micro‐features using variothermal injection molding: Application to micro‐fluidics

Replication of surface micro‐features using variothermal injection molding: Application to micro‐fluidics

Biomarker detection for disease diagnosis using cost-effective microfluidic platforms

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