Charakterisierung der extended spectrum b-Lactamasen (ESBL) und Bestimmung der von Kindern isolierten uropathogenen Virulenzfaktoren von Escherichia coli (E. coli) Stämmen

Bedenić, Branka; Vraneš, Jasmina; Hofmann-Thiel, Sabine; Tonkić, Marija; Novak, Anita; Bučević-Popović, Viljemka; Hoffmann, Harald

doi:10.1007/s00508-012-0210-5

Cited by 7 publications

(6 citation statements)

References 44 publications

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“…In the early 2000s, SHV-5 was the most common ESBL in Europe, with SHV-12 predominating in some countries [53]. Data from pediatric studies done in Croatia during this time period found that 74% (57/77) of ESBL E. coli UTI isolates carried SHV-type ESBLs (66% were SHV-5, whereas only 2.5% were CTX-M type); in Hungary, 77% (30/39) of pediatric ESBL Klebsiella clinical isolates were SHV-5-type ESBLs with the remaining isolates harboring TEM-1/SHV-12-type ESBLs [51,53]. By 2009, a study performed in a NICU in Poland showed that nearly 90% of all ESBLs were CTX-M producers, with CTX-M-3, CTX-M-15, and CTX-M-9 constituting 48.9%, 27.6%, and 12.7% of ESBLs, respectively [54].…”

Section: Europementioning

confidence: 97%

Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae in Children: Old Foe, Emerging Threat

Lukac¹,

Bonomo

Logan

2015

Clinical Infectious Diseases

122

144

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Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae present an ever-growing burden in the hospital and community settings, across all ages and demographics. Infections due to ESBL-containing pathogens continue to be associated with significant morbidity and mortality worldwide. With widespread empiric broad-spectrum β-lactam use creating selective pressure, and the resultant emergence of stable, rapidly proliferating ESBL-producing clones with continued horizontal gene transfer across genera, addressing this issue remains imperative. Although well characterized in adults, the epidemiology, risk factors, outcomes, therapies, and control measures for ESBL-producing bacteria are less appreciated in children. This analysis provides a brief summary of ESBL-producing Enterobacteriaceae in children, with a focus on recent clinical and molecular data regarding colonization and infection in nonoutbreak settings.

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Section: Europementioning

confidence: 97%

Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae in Children: Old Foe, Emerging Threat

Lukac¹,

Bonomo

Logan

2015

Clinical Infectious Diseases

122

144

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“…CTX-M-15 was the dominant type, albeit CTX-M-3 was also found in some isolates [ 43 ]. bla CTX-M genes were carried by FIA and L/M plasmids (according to the plasmid incompatibility grouping) in the early 1990s, and SHV-2 and SHV-5 were found in UTI isolates of E. coli [ 45 ]. They caused urinary tract infections in neonates and young children, and they were associated with specific virulence factors such as resistance to serum bactericidal activity and haemolysin production.…”

Section: Escherichia Colimentioning

confidence: 99%

Mechanisms of Resistance in Gram-Negative Urinary Pathogens: From Country-Specific Molecular Insights to Global Clinical Relevance

Bedenić

Meštrović

2021

Diagnostics

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Urinary tract infections (UTIs) are the most frequent hospital infections and among the most commonly observed community acquired infections. Alongside their clinical importance, they are notorious because the pathogens that cause them are prone to acquiring various resistance determinants, including extended-spectrum beta-lactamases (ESBL); plasmid-encoded AmpC β-lactamases (p-AmpC); carbapenemases belonging to class A, B, and D; qnr genes encoding reduced susceptibility to fluoroquinolones; as well as genes encoding enzymes that hydrolyse aminoglycosides. In Escherichia coli and Klebsiella pneumoniae, the dominant resistance mechanisms are ESBLs belonging to the CTX-M, TEM, and SHV families; p-AmpC; and (more recently) carbapenemases belonging to classes A, B, and D. Urinary Pseudomonas aeruginosa isolates harbour metallo-beta-lactamases (MBLs) and ESBLs belonging to PER and GES families, while carbapenemases of class D are found in urinary Acinetobacter baumannii isolates. The identification of resistance mechanisms in routine diagnostic practice is primarily based on phenotypic tests for the detection of beta-lactamases, such as the double-disk synergy test or Hodge test, while polymerase chain reaction (PCR) for the detection of resistance genes is mostly pursued in reference laboratories for research purposes. As the emergence of drug-resistant bacterial strains poses serious challenges in the management of UTIs, this review aimed to appraise mechanisms of resistance in relevant Gram-negative urinary pathogens, to provide a detailed map of resistance determinants in Croatia and the world, and to discuss the implications of these resistance traits on diagnostic approaches. We summarized a sundry of different resistance mechanisms among urinary isolates and showed how their prevalence highly depends on the local epidemiological context, highlighting the need for tailored interventions in the field of antimicrobial stewardship.

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“…Antimicrobial resistance is also on the rise in European countries that were not included in the last annual ECDC report (Table 3) [19,57,59,66,73,74]. In a recent surveillance study conducted in 42 centres in Eastern Europe, about 15% of E. coli isolates were ESBL-positive and were collected in all countries participating in this project [59].…”

Section: Epidemiology Of Resistancementioning

confidence: 99%

Escherichia coli in Europe: An Overview

Allocati

Masulli

Alexeyev

et al. 2013

IJERPH

376

259

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Escherichia coli remains one of the most frequent causes of several common bacterial infections in humans and animals. E. coli is the prominent cause of enteritis, urinary tract infection, septicaemia and other clinical infections, such as neonatal meningitis. E. coli is also prominently associated with diarrhoea in pet and farm animals. The therapeutic treatment of E. coli infections is threatened by the emergence of antimicrobial resistance. The prevalence of multidrug-resistant E. coli strains is increasing worldwide principally due to the spread of mobile genetic elements, such as plasmids. The rise of multidrug-resistant strains of E. coli also occurs in Europe. Therefore, the spread of resistance in E. coli is an increasing public health concern in European countries. This paper summarizes the current status of E. coli strains clinically relevant in European countries. Furthermore, therapeutic interventions and strategies to prevent and control infections are presented and discussed. The article also provides an overview of the current knowledge concerning promising alternative therapies against E. coli diseases.

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Charakterisierung der extended spectrum b-Lactamasen (ESBL) und Bestimmung der von Kindern isolierten uropathogenen Virulenzfaktoren von Escherichia coli (E. coli) Stämmen

Abstract: Background and aim

Cited by 7 publications

References 44 publications

Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae in Children: Old Foe, Emerging Threat

Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae in Children: Old Foe, Emerging Threat

Mechanisms of Resistance in Gram-Negative Urinary Pathogens: From Country-Specific Molecular Insights to Global Clinical Relevance

Escherichia coli in Europe: An Overview

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