1959
DOI: 10.1136/bmj.1.5127.952
|View full text |Cite
|
Sign up to set email alerts
|

Charcot's Arthropathy Following Intra-articular Hydrocortisone

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
18
0

Year Published

1960
1960
2009
2009

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 93 publications
(18 citation statements)
references
References 5 publications
0
18
0
Order By: Relevance
“…Case 2 received only three injections into her hip, but nevertheless rapid and severe joint destruction developed. The only other patient recorded in the literature to have developed similar changes after intraarticular injection alone required 18 monthly injections before developing the typical arthropathy (Chandler et al, 1959). Conclusion Ever since cortisone and its equivalents became freely available in Great Britain the use of corticosteroids in both hospital and general practice has increased.…”
Section: Discussionmentioning
confidence: 98%
See 2 more Smart Citations
“…Case 2 received only three injections into her hip, but nevertheless rapid and severe joint destruction developed. The only other patient recorded in the literature to have developed similar changes after intraarticular injection alone required 18 monthly injections before developing the typical arthropathy (Chandler et al, 1959). Conclusion Ever since cortisone and its equivalents became freely available in Great Britain the use of corticosteroids in both hospital and general practice has increased.…”
Section: Discussionmentioning
confidence: 98%
“…Pietrograndi and Mastromarino (1957) have reported such hip destruction in a woman treated for four years with cortisone by mouth in a dose of 100 mg. daily. A similar change in the osteoarthritic hip of a patient who received 18 intraarticular injections of 50 mg. hydrocortisone at monthly intervals has been reported by Chandler et al (1959). Others have been recorded by Murray (1960) and Sweetnam (1960).…”
mentioning
confidence: 85%
See 1 more Smart Citation
“…Chromatographic studies of the persistence of the steroid favour methylprednisolone acetate, but this compound had a higher relapse rate. Chandler et al (1958Chandler et al ( , 1959 have shown that progressive joint deterioration may occur after repeated injections of hydrocortisone preparations, and suggest that radiological control is desirable. One of their osteoarthritic patients developed changes resembling a Charcot arthropathy.…”
Section: Clinical Resultsmentioning
confidence: 99%
“…However, the rapid relief of symptoms, as well as the restoration of the functional levels of joints, eventually led to the indiscriminate use of those drugs. Case reports of Charcot's arthropathy, bone necroses and an increase in articular cartilage degeneration were prominent in the years following the introduction of that modality of treatment 1,2 . Experimentally, corticosteroids cause lesions in the cartilage tissue by inducing proteoglycan loss, a fact that plays a key role in the degeneration of articular cartilages.…”
Section: Original Articlementioning
confidence: 99%