Chard (Beta Vulgaris Var. Cicla) Extract Modulates Zinc Status, Glucose Level and Antioxydant Values in Diabetic Rats Fed Zinc Deficiency Diet

Abstract

Objective: Oxidative stress which comes from hyperglycemia, it accelerates the development of cellular and vascular damage complications in diabetes, but the antioxidants may play a beneficial role in its prevention. Several plants extracts have an antioxidant activity and the ability to reduce oxidative stress in diabetes. Thus this study was conducted to investigate the effect of Beta vulgaris var cicla extract on zinc status, glucose concentration and antioxidant parameters in streptozotocin-diabetic rats fed zinc deficiency diet.Methods: Twenty-eight male albino (Wistar) rats were divided into four groups:Results: Body weight gain of zinc-deficient diabetic animals was lower than that of zinc-adequate diabetic animals. It was noticed also that inadequate dietary zinc intake increased glucose and MDA levels. In addition, zinc deficiency diet led to a decrease in zinc tissues, GSH concentration both GST and GSH-Px activities. However, Oral administration of Beta vulgaris extract significantly decreased both serum glucose and MDA (p<0.001) levels, with a significant increase in body weight gain (p<0.001), GSH concentration (p<0.05, P<0.001), GST (p<0.05, p<0.001) and GSHPx (p<0.001) activities.two groups fed a zinc-sufficient diet one non-diabetic and the other diabetic, while the others two diabetic groups were fed a zinc-deficient diet, one non-treated group and the other treated with the extract of Beta vulgaris var cicla. After 21 d of dietary manipulation, fasting animals were scarified. Blood glucose, tissues zinc (femur, liver, kidney), malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GSH-Px) and glutathione-S-transferase (GST) were evaluated. Conclusion:The present study showed that Beta vulgaris var cicla supplementation presumably acting as an antioxidant, and it can be a natural Keywords: Diabetes, Rat, Zinc deficiency, Beta vulgaris var cicla, Antioxidant source for the reduction of diabetes development caused by zinc deficiency.

The Benefit Effect of Ginger Supplementation Against Nickel-Induced Hepatotoxicity in Albino Wistar Rats

“…The findings of the present study showed a significant reduction in body weight of Ni exposed group. The decreased body weight is concomitant with previously reports [42,43]. This reduction in weights might as a result of the overall increased degeneration of lipids and proteins [9] and a decrease of appetite.…”

The possible hypo-lipidemic effect of aqueous extract of gamma-irradiated chard leaves in rats fed high fat diet

“…Mitochondrial dysfunction can also lead to apoptosis or necrosis depending on the energy status of the cell [30].Vincent [45] reported that the HFD caused increase in lipid precipitation in the myocardium which performs a good substrate for lipid peroxidation in cardiac tissue by free radicals. Rat fed on HFD with RCLAE or GCLAE results agrees with Hamdiken and Kechrid [46] who concluded that chard played a positive role in decreasing MDA levels and increasing the GSH levels in rats exposed to ethanolic toxicity. The anti-oxidant and free radical-scavenging activities of chard could be attributed to its active components such as phenolic contents, flavonoid, glycosides and saponins [4].…”

Phytochemicals Screening and Activities of Binahong (Anredera Cordifolia [Ten.] Steenis) Leaves and Beetroots (Beta Vulgaris L.) in Increasing Swimming Endurance in Mice

“…Beetroot (Beta vulgaris) belongs to the Chenopodiaceae family and is originally from temperate climate regions of Mediterranean, extensively cultivated in Europe, America, and many parts of India. Aqueous and ethanol extracts of beetroots have been reported to possess free radical scavenging activity, reducing the radical cations and Phase II enzyme-inducing activities in murine hepatoma cell in vitro study [8][9][10].…”