Charge inversion by multivalent ions: Dependence on dielectric constant and surface-charge density

Besteman, K.; Zevenbergen, Marcel A. G.; Lemay, Serge G.

doi:10.1103/physreve.72.061501

Cited by 125 publications

(160 citation statements)

References 31 publications

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“…Also, experimental studies on the effects of different factors on the distribution of the counterions and interaction between charged dielectrics can also be insightful. For example, the effect of the dielectric inhomogeneity on the interaction of two charged dielectrics seems to be possible by changing the solvent [30] and is not studied yet to the authors knowledge.…”

Section: Discussion and Concluding Remarksmentioning

confidence: 99%

Distribution of counterions and interaction between two similarly charged dielectric slabs: Roles of charge discreteness and dielectric inhomogeneity

et al. 2012

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The distribution of counterions and the electrostatic interaction between two similarly charged dielectric slabs is studied in the strong coupling limit. Dielectric inhomogeneities and discreteness of charge on the slabs have been taken into account. It is found that the amount of dielectric constant difference between the slabs and the environment, and the discreteness of charge on the slabs have opposing effects on the equilibrium distribution of the counterions. At small inter-slab separations, increasing the amount of dielectric constant difference increases the tendency of the counterions toward the middle of the intersurface space between the slabs and the discreteness of charge pushes them to the surfaces of the slabs. In the limit of point charges, independent of the strength of dielectric inhomogeneity, counterions distribute near the surfaces of the slabs. The interaction between the slabs is attractive at low temperatures and its strength increases with the dielectric constant difference. At room temperature, the slabs may completely attract each other, reach to an equilibrium separation or have two equilibrium separations with a barrier in between, depending on the system parameters.

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Section: Discussion and Concluding Remarksmentioning

confidence: 99%

Distribution of counterions and interaction between two similarly charged dielectric slabs: Roles of charge discreteness and dielectric inhomogeneity

et al. 2012

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“…High-affinity binding, in combination with fast kinetics, is a feature of cationic binding to nucleic acids in a predominately electrostatic mode (5,16,49,50,63,71,88,90,91). Such electrostatic binding leads to the formation of protein-induced nucleic acid aggregates that are characterized by high mobility of nucleic acid and protein (5,15,16,50,63,80,87,92,94,102), thereby strongly facilitating the bimolecular steps of nucleic acid annealing. However, purely electrostatic binding results in stabilization of the double-stranded, rather than the single-stranded, form of nucleic acids (17), whereas duplex destabilization requires preferential binding to the single-stranded form.…”

Section: Discussionmentioning

confidence: 99%

Retroviral Nucleocapsid Proteins Display Nonequivalent Levels of Nucleic Acid Chaperone Activity

Stewart-Maynard

Cruceanu

Wang

et al. 2008

J Virol

161

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Human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein (NC) is a nucleic acid chaperone that facilitates the remodeling of nucleic acids during various steps of the viral life cycle. Two main features of NC's chaperone activity are its abilities to aggregate and to destabilize nucleic acids. These functions are associated with NC's highly basic character and with its zinc finger domains, respectively. While the chaperone activity of HIV-1 NC has been extensively studied, less is known about the chaperone activities of other retroviral NCs. In this work, complementary experimental approaches were used to characterize and compare the chaperone activities of NC proteins from four different retroviruses: HIV-1, Moloney murine leukemia virus (MLV), Rous sarcoma virus (RSV), and human T-cell lymphotropic virus type 1 (HTLV-1). The different NCs exhibited significant differences in their overall chaperone activities, as demonstrated by gel shift annealing assays, decreasing in the order HIV-1 ϳ RSV > MLV Ͼ Ͼ HTLV-1. In addition, whereas HIV-1, RSV, and MLV NCs are effective aggregating agents, HTLV-1 NC, which exhibits poor overall chaperone activity, is unable to aggregate nucleic acids. Measurements of equilibrium binding to single-and double-stranded oligonucleotides suggested that all four NC proteins have moderate duplex destabilization capabilities. Single-molecule DNAstretching studies revealed striking differences in the kinetics of nucleic acid dissociation between the NC proteins, showing excellent correlation between nucleic acid dissociation kinetics and overall chaperone activity.

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“…Up to now, CR has been verified for a number of colloidal systems and compared quantitatively to the predictions of theory [8][9][10][11][12][13][14]. However, it remains difficult to unambiguously determine the driving force for CR in experiments [15].…”

Section: Introductionmentioning

confidence: 95%

Experimental study of electrostatically stabilized colloidal particles: Colloidal stability and charge reversal

Schneider

Hanisch

Wedel

et al. 2011

Journal of Colloid and Interface Science

109

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Charge inversion by multivalent ions: Dependence on dielectric constant and surface-charge density

Cited by 125 publications

References 31 publications

Distribution of counterions and interaction between two similarly charged dielectric slabs: Roles of charge discreteness and dielectric inhomogeneity

Distribution of counterions and interaction between two similarly charged dielectric slabs: Roles of charge discreteness and dielectric inhomogeneity

Retroviral Nucleocapsid Proteins Display Nonequivalent Levels of Nucleic Acid Chaperone Activity

Experimental study of electrostatically stabilized colloidal particles: Colloidal stability and charge reversal

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