Magicity, or shell closure, plays an important role in our understanding of complex nuclear phenomena. In this work, we employ one of the state-of-the-art density functional theories, the deformed relativistic Hartree-Bogoliubov theory in continuum (DRHBc) with the density functional PC-PK1, to investigate the evolution of the $N=20,28,50$ shell closures in
the $ 20 \leqslant Z \leqslant 30$ region. We show how these three conventional shell closures evolve from the proton drip line to the neutron drip line by studying the charge radii, two-neutron separation energies, two-neutron gaps, quadrupole deformations, and single-particle levels. In particular, we find that in the $ 21 \leqslant Z \leqslant 27$ region, the $N=50$ shell closure disappears or becomes quenched, mainly due to the deformation effects. Similarly, both experimental data and theoretical predictions indicate that the $N=28$ shell closure disappears in the Mn isotopic chain, also predominantly due to the deformation effects. The DRHBc theory predicts the existence of the $N=20$ shell closure in the Ca, Sc, and Ti isotopic chains, but the existing data for the Ti isotopes suggests the contrary, and therefore more investigations are needed.