Charge-reversal biodegradable MSNs for tumor synergetic chemo/photothermal and visualized therapy

Li, Zimu; Yang, Yao; Wei, Huaxuan; Shan, Xiaoting; Wang, Xuanzhi; Ou, Meitong; Liu, Qingyun; Gao, Nansha; Chen, Hongzhong; Mei, Lin; Zeng, Xiaowei

doi:10.1016/j.jconrel.2021.09.005

Cited by 165 publications

(86 citation statements)

References 52 publications

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“…However, endogenous stimuli affected by tumor heterogeneity might reduce the responsiveness of the nanocarriers, impeding their further application. Exogenous stimuli, such as: light, radiation, heat, and electric and magnetic fields, are more controllable and homogeneous 27 , 29 - 31 . Among them, NIR light in the “therapeutic window” (720-900 nm) is considered to be one of the most promising stimuli because of its advantages of: spatiotemporal control, deep tissue penetration, non-invasion, and safety 27 , 31 .…”

Section: Introductionmentioning

confidence: 99%

“…Exogenous stimuli, such as: light, radiation, heat, and electric and magnetic fields, are more controllable and homogeneous 27 , 29 - 31 . Among them, NIR light in the “therapeutic window” (720-900 nm) is considered to be one of the most promising stimuli because of its advantages of: spatiotemporal control, deep tissue penetration, non-invasion, and safety 27 , 31 . Nevertheless, most of these transformable nanocarriers are triggered by a single stimulus.…”

Section: Introductionmentioning

confidence: 99%

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A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy

Peng¹,

Chen²,

Liu³

et al. 2022

Theranostics

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Designing a transformable nanosystem with improved tumor accumulation and penetration by tuning multiple physicochemical properties remains a challenge. Here, a near-infrared (NIR) light-driven nanosystem with size and charge dual-transformation for deep tumor penetration is developed. Methods: The core-shell nanotransformer is realized by integrating diselenide-bridged mesoporous organosilica nanoparticles as a reactive oxygen species (ROS)-responsive core with an indocyanine green (ICG)-hybrid N-isopropyl acrylamide layer as a thermosensitive shell. After loading doxorubicin (DOX), negatively charged nanomedicine prevents DOX leakage, rendering prolonged blood circulation time and high tumor accumulation. Results: Upon NIR light irradiation, mild photothermal effects facilitate the dissociation of the thermosensitive shell to achieve negative-to-positive charge reversal. Meanwhile, ICG-generated ROS cleave the diselenide bond of the organosilica core, resulting in rapid matrix degradation that produces DOX-containing smaller fragments. Such a light-driven dual-transformable nanomedicine simultaneously promotes deep tumor penetration and implements sufficient chemotherapy, along with evoking robust immunogenic cell death effects in vitro and in vivo . With the combination of a programmed cell death protein-1 (PD-1) checkpoint blockade, the nanotransformer remarkably blocks primary tumor growth and pulmonary metastasis of breast cancer with low systemic toxicity. Conclusions: This study develops a promising strategy to realize high tumor accumulation and deep penetration of light-transformable nanomedicine for efficient and safe chemo-immunotherapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy

Peng¹,

Chen²,

Liu³

et al. 2022

Theranostics

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“…The loading capacity of DOX was 55.89%, which was higher than traditional drug delivery systems. 32–34 As shown in Fig. S21a and b (ESI†), compared with the DOX (absorption peak at 490 nm) and GluC (absorption peak at 450 nm), GluCCD showed two characteristic absorption peaks of DOX + Cu 2+ at 565 nm and GluCC at 470 nm.…”

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confidence: 95%

A glycol nanomedicine via a metal-coordination supramolecular self-assembly strategy for drug release monitoring and chemo-chemodynamic therapy

Li¹,

Wang²,

Pei³

et al. 2022

Chem. Commun.

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“…It is considered to be the most promising method in cancer treatment. In recent years, new tumor-targeted strategies have emerged, such as tumor-targeted drug therapy ( Jin et al, 2021 ; Kerns et al, 2021 ; Li et al, 2021 ; Li et al, 2021 ), immunotherapy ( Chen et al, 2021 ; Lu et al, 2021 ; Pei et al, 2021 ), gene therapy ( Chada et al, 2015 ; Wang et al, 2021 ; Wang et al, 2021 ), virus therapy ( Kemler et al, 2021 ; Wan et al, 2021 ; Zhang et al, 2021 ), and cell-based targeted therapy ( Collet et al, 2016 ). Among them, tumor active targeted drug therapy based on nanoparticles (NPs) drug delivery systems achieved the most success.…”

Section: Introductionmentioning

confidence: 99%

Dacarbazine-Loaded Targeted Polymeric Nanoparticles for Enhancing Malignant Melanoma Therapy

Xiong¹,

Guo²,

Zeng³

et al. 2022

Front. Bioeng. Biotechnol.

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Dacarbazine (DTIC) dominates chemotherapy for malignant melanoma (MM). However, the hydrophobicity, photosensitivity, instability, and toxicity to normal cells of DTIC limit its efficacy in treating MM. In the present study, we constructed star-shaped block polymers nanoparticles (NPs) based on Cholic acid -poly (lactide-co-glycolide)-b-polyethylene glycol (CA-PLGA-b-PEG) for DTIC encapsulation and MM targeted therapy. DTIC-loaded CA-PLGA-b-PEG NPs (DTIC-NPs) were employed to increase the drug loading and achieve control release of DTIC, followed by further modification with nucleic acid aptamer AS1411 (DTIC-NPs-Apt), which played an important role for active targeted therapy of MM. In vitro, DTIC-NPs-Apt showed good pH-responsive release and the strongest cytotoxicity to A875 cells compared with DTIC-NPs and free DTIC. In vivo results demonstrated that the versatile DTIC-NPs-Apt can actively target the site of MM and exhibited excellent anti-tumor effects with no obvious side effects. Overall, this research provided multi-functional NPs, which endow a new option for the treatment of MM.

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Charge-reversal biodegradable MSNs for tumor synergetic chemo/photothermal and visualized therapy

Cited by 165 publications

References 52 publications

A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy

A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy

A glycol nanomedicine via a metal-coordination supramolecular self-assembly strategy for drug release monitoring and chemo-chemodynamic therapy

Dacarbazine-Loaded Targeted Polymeric Nanoparticles for Enhancing Malignant Melanoma Therapy

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