Finding a clear signature of topological superconductivity in transport experiments remains an outstanding challenge. In this work, we propose exploiting the unique properties of threedimensional topological insulator nanowires to generate a normal-superconductor junction in the single-mode regime where an exactly quantized 2e 2 /h zero-bias conductance can be observed over a wide range of realistic system parameters. This is achieved by inducing superconductivity in half of the wire, which can be tuned at will from trivial to topological with a parallel magnetic field, while a perpendicular field is used to gap out the normal part, except for two spatially separated chiral channels. The combination of chiral mode transport and perfect Andreev reflection makes the measurement robust to moderate disorder, and the quantization of conductance survives to much higher temperatures than in tunnel junction experiments. Our proposal may be understood as a variant of a Majorana interferometer which is easily realizable in experiments.A topological superconductor is a proposed novel phase of matter with exotic properties like protected boundary states and emergent quasiparticles with non-Abelian statistics. If realized, these superconductors are expected to constitute the main building block of topological quantum computers [1]. The prototypical example of this phase, the p-wave superconductor, has proven to be difficult to find in nature, with superconducting Sr 2 RuO 4 and, indirectly, the ν = 5/2 fractional quantum Hall state among the very few conjectured candidates. While many experiments have been suggested and performed on these systems, evidence for their topological properties remains elusive. However, the recent realization that a p-wave superconductor need not be intrinsic, but can alternatively be engineered with regular s-wave superconducting proximity effect in strongly spin-orbit coupled materials [2][3][4], has opened a promising new path in the search for topological superconductivity.