Charge Storage in Graphene Oxide: Impact of the Cation on Ion Permeability and Interfacial Capacitance

Paschoalino, Waldemir J.; Payne, Nicholas A.; Pessanha, Tatiana M.; Gateman, Samantha Michelle; Kubota, Lauro T.; Mauzeroll, Janine

doi:10.1021/acs.analchem.0c00218

Cited by 11 publications

(12 citation statements)

References 64 publications

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“…Device model parameters As described in Section 2.2, the surface charge on the graphene oxide in 0.001M N aCl was determined approximately as −75 mC m −2 in good agreement with the previous work [36] where the value was equal −80 mC m −2 , at pH 6.5 extracted from a zeta potential measurement, albeit in NaCl. In CGS units, these two values correspond to −22, 484.43 statC cm −2 and −23, 983.39 statC cm −2 .…”

Section: Electrical Parameters Of Modelsupporting

confidence: 85%

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Performance assessment of an electrostatic filter-diverter stent cerebrovascular protection device

Eguzkitza

Oks

Navia

et al. 2023

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Stroke is the second leading cause of death worldwide. Nearly two-thirds of strokes are produced by cardioembolisms, and half of cardioembolic strokes are triggered by Atrial Fibrillation (AF), the most common type of arrhythmia. A more recent cause of cardioembolisms is Transcatheter Aortic Valve Replacements (TAVRs), which may onset post-procedural adverse events such as stroke and Silent Brain Infarcts (SBIs), for which no definitive treatment exists, and which will only get worse as TAVRs are implanted in younger and lower risk patients. It is well known that some specific characteristics of elderly patients may lower the safety and efficacy of anticoagulation therapy, making it a real urgency to find alternative therapies. The device introduced in this manuscript offers an anticoagulant-free method to prevent stroke and SBIs, imperative given the growing population of AF and elderly patients. This work analyzes a design based on a patented medical device, intended to block cardioembolisms from entering the cerebrovascular system, with a particular focus on AF, and potentially TAVR patients. The study has been carried out using computational fluid dynamics coupled with Lagrangian particle tracking to analyse the efficacy of a novel patented medical device intended to block cardioembolisms from entering the cerebrovascular system, with a particular focus on AF, and potentially TAVR patients. The studied device consists of a strut structure deployed at the base of the treated artery. Particles of different sizes are used to model dislodged debris, which could potentially lead to cerebral embolisms if transported into these arteries. The device demonstrated a two-fold mechanism for filtering emboli: while the smallest particles are deflected by electrostatic repulsion, avoiding microembolisms, which could lead to cognitive impairment, the largest ones are mechanically filtered since they cannot fit in between the struts, effectively blocking the full range of particle sizes analyzed in this study.

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Section: Electrical Parameters Of Modelsupporting

confidence: 85%

“…The device would be covered with a negatively charged graphene oxide coating, with surface charges of −24000.0 statC cm −2 , which corresponds to the most extreme electrical charges found in the literature of biomedical devices, as will be described later in section 2.3.2. [36].…”

Section: Device Designmentioning

confidence: 99%

Performance assessment of an electrostatic filter-diverter stent cerebrovascular protection device

Eguzkitza

Oks

Navia

et al. 2023

Preprint

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“…We postulate that the enhanced capacitance observed in the multilayer GO film can be attributed to the interlayer spacing and folding of the GO sheets in the film structure, which favored the storage of charged species in the film through the permeation of the solvent and the diffusion/accumulation of ions [16b]. This result agrees with the features observed by the effect of solution pH in the C i values obtained in the presence of different concentrations of sodium ions (Figure S3).The increase in the concentration of sodium ions, at pH 3, resulted in a slight increase of the C i values from 350 μF mg −1 in 30 mmol L −1 to 600 μF mg −1 in 70 mmol L −1 (Figure S3).…”

Section: Resultsmentioning

confidence: 96%

“…Epoxide groups exhibit stronger interactions with lithium ions, while for carboxyl groups, the lithium‐ion interaction is minimal due to the absence of Li−O binding [23]. The interaction between Na + and the oxygen functional groups, such as epoxy and carbonyl, is much stronger, increasing the overall capacitance of the system [16b]. To compare the effect of the cation size on the electrochemical/capacitive behavior of the GO films, lithium, sodium, and tetramethylammonium (TMA + ) ions were studied.…”

Section: Resultsmentioning

confidence: 99%

Interfacial Capacitance of Graphene Oxide Films Electrodes: Fundamental Studies on Electrolytes Interface Aiming (Bio)Sensing Applications

et al. 2021

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The understanding of bidimensional materials dynamics and its electrolyte interface equilibrium, such as graphene oxide (GO), is critical for the development of a capacitive biosensing platform. The interfacial capacitance (C i ) of graphene-based materials may be tuned by experimental conditions such as pH optimization and cation size playing key roles at the enhancement of their capacitive properties allowing their application as novel capacitive biosensors. Here we reported a systematic study of C i of multilayer GO films in different aqueous electrolytes employing electrochemical impedance spectroscopy for the application in a capacitive detection system. We demonstrated that the presence of ionizable oxygen-containing functional groups within multilayer GO film favors the interactions and the accumulation of cations in the structure of the electrodes enhancing the GO C i in aqueous solutions, where at pH 7.0 (the best condition) the C i was 340 μF mg À 1 at À 0.01 V vs Ag/AgCl. We also established that the hydrated cation radius affects the mobility and interaction with GO functional groups and it plays a critical role in the Ci, as demonstrated in the presence of different cations Na + = 640 μF mg À 1 , Li + = 575 μF mg À 1 and TMA + = 477 μF mg À 1 . As a proof-ofconcept, the capacitive behaviour of GO was explored as biosensing platform for standard streptavidin-biotin systems. For this system, the C i varied linearly with the log of the concentration of the targeting analyte in the range from 10 pg mL À 1 to 100 ng mL À 1 , showing the promising applicability of capacitive GO based sensors for label-free biosensing.

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“…The negative charge of GO sheets renders them useful for the construction of nanofluidic ion transport channels, wherein a tendency to attract cations and repel anions is observed. [81,82] In addition, GO can be modified with different metals, semiconductors, or nanostructures [67,83,84] via non-covalent interactions, such as electrostatic interactions between negative charges or van der Waals forces between residual hydrophobic domains. These modifications will be described in detail in Section 3.…”

Section: Structure Functional Groups and Properties Of Go And Rgomentioning

confidence: 99%

Structure, Properties, and Electrochemical Sensing Applications of Graphene‐Based Materials

et al. 2020

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Owing to their versatility and unique characteristics, graphene‐based materials have been used extensively for the development of electrochemical sensors and biosensors. The key to the maximum potential of these materials is the understanding of the role their structure plays in their modification processes. Herein, we summarize some structural characteristics of graphene oxide (GO) and reduced graphene oxide (rGO) and explore different surface modification methods for electrochemical sensing applications. surveyed the most recent applications of these materials as (bio)sensors, particularly for environmental monitoring and health‐related applications, such as quantification of biomarkers and metabolites and detection of cancer cells. The low detection limits, selectivity toward target molecules, and robustness of GO‐ and rGO‐based electrodes render them critical materials for the preparation of sensors for routine analysis and monitoring.

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Charge Storage in Graphene Oxide: Impact of the Cation on Ion Permeability and Interfacial Capacitance

Cited by 11 publications

References 64 publications

Performance assessment of an electrostatic filter-diverter stent cerebrovascular protection device

Performance assessment of an electrostatic filter-diverter stent cerebrovascular protection device

Interfacial Capacitance of Graphene Oxide Films Electrodes: Fundamental Studies on Electrolytes Interface Aiming (Bio)Sensing Applications

Structure, Properties, and Electrochemical Sensing Applications of Graphene‐Based Materials

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